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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2008

01-10-2008 | Editorial

An important step towards completing the rheumatoid arthritis cycle

Authors: Walther J van Venrooij, Ger JM Pruijn

Published in: Arthritis Research & Therapy | Issue 5/2008

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Abstract

In the previous issue of Arthritis Research & Therapy data are presented showing that circulating immune complexes containing citrullinated fibrin(ogen) are present in anti-citrullinated protein antibody-positive rheumatoid arthritis patients, and that such immune complexes co-localize with complement factor C3 in the rheumatoid synovium. These results corroborate the idea that citrullination is intimately involved in the pathophysiology of rheumatoid arthritis and complete our model (the rheumatoid arthritis cycle) for the development and chronic nature of this disease.
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Literature
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Van Venrooij WJ, Van Beers J, Pruijn GJM: Anti-CCP antibody, a marker for the early detection of rheumatoid arthritis. Ann NY Acad Sci. 2008,
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Masson-Bessière C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, Senshu T, Serre G: The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol. 2001, 166: 4177-4184.CrossRefPubMed
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Vossenaar ER, Van Venrooij WJ: Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. Arthritis Res Ther. 2004, 6: 107-111. 10.1186/ar1184.PubMedCentralCrossRefPubMed
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Vossenaar ER, Zendman AJ, Van Venrooij WJ: Citrullination, a possible functional link between susceptibility genes and rheumatoid arthritis. Arthritis Res Ther. 2004, 6: 1-5. 10.1186/ar1027.PubMedCentralCrossRefPubMed
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van Gaalen F, Ioan-Facsinay A, Huizinga TW, Toes RE: The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis. J Immunol. 2005, 175: 5575-5580.CrossRefPubMed
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Metadata
Title
An important step towards completing the rheumatoid arthritis cycle
Authors
Walther J van Venrooij
Ger JM Pruijn
Publication date
01-10-2008
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2008
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2504

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