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01-04-2008 | Review

Recent developments in the immunobiology of rheumatoid arthritis

Authors: Anna K Andersson, Ching Li, Fionula M Brennan

Published in: Arthritis Research & Therapy | Issue 2/2008

Abstract

Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies, and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis.

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Title: Recent developments in the immunobiology of rheumatoid arthritis
Authors: Anna K Andersson
Ching Li
Fionula M Brennan
Publication date: 01-04-2008
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 2/2008
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2370

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