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Published in:

01-06-2007 | Review

Current status of lupus genetics

Authors: Andrea L Sestak, Swapan K Nath, Amr H Sawalha, John B Harley

Published in: Arthritis Research & Therapy | Issue 3/2007

Abstract

Over the past 40 years more than 100 genetic risk factors have been defined in systemic lupus erythematosus through a combination of case studies, linkage analyses of multiplex families, and case-control analyses of single genes. Multiple investigators have examined patient cohorts gathered from around the world, and although we doubt that all of the reported associations will be replicated, we have probably already discovered many of the genes that are important in lupus pathogenesis, including those encoding human leukocyte antigen-DR, Fcγ receptor 3A, protein tyrosine phosphatase nonreceptor 22, cytotoxic T lymphocyte associated antigen 4, and mannose-binding lectin. In this review we will present what is known, what is disputed, and what remains to be discovered in the world of lupus genetics.

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Title: Current status of lupus genetics
Authors: Andrea L Sestak
Swapan K Nath
Amr H Sawalha
John B Harley
Publication date: 01-06-2007
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 3/2007
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2176

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