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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2007

Open Access 01-04-2007 | Research article

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis

Authors: Pierre-Antoine Gourraud, Philippe Dieudé, Jean-Frédéric Boyer, Leonor Nogueira, Anne Cambon-Thomsen, Bernard Mazières, François Cornélis, Guy Serre, Alain Cantagrel, Arnaud Constantin

Published in: Arthritis Research & Therapy | Issue 2/2007

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Abstract

The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping the shared epitope (SE) hypothesis, was recently found relevant in terms of RA susceptibility and structural severity.
We investigated the relevance of this new classification of HLA-DRB1 SE+ alleles in terms of rheumatoid factor (RF) and ACPA production in a sample of French RA patients.
We studied 160 early RA patients included in a prospective longitudinal cohort of French Caucasian patients with recent-onset arthritis. RF, anticyclic citrullinated peptide 2 (anti-CCP2) and antideiminated human fibrinogen autoantibodies (AhFibA) were assessed in all patients at inclusion. The HLA-DRB1 gene was typed by PCR-sequence specific oligonucleotides probes (PCR-SSOP), and SE+ alleles were classified into four groups (S1, S2, S3P, S3D) according to the new classification.
The new classification of HLA-DRB1 SE+ alleles distinguishes predisposing and protective alleles for RF, anti-CCP2 or AhFibA production. The presence of S2 or S3P alleles is associated with both RF, anti-CCP2 or AhFibA positivity, whereas the presence of S3D or S1 alleles appears to be protective for RF, anti-CCP2 or AhFibA positivity.
The new classification of HLA-DRB1 SE+ alleles is relevant in terms of autoantibody production in early RA patients by differentiating predisposing and protective alleles for RF or ACPA production.
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Metadata
Title
A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis
Authors
Pierre-Antoine Gourraud
Philippe Dieudé
Jean-Frédéric Boyer
Leonor Nogueira
Anne Cambon-Thomsen
Bernard Mazières
François Cornélis
Guy Serre
Alain Cantagrel
Arnaud Constantin
Publication date
01-04-2007
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2007
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2131

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