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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2007

01-02-2007 | Meeting report

Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005

Authors: Alan Tyndall, Ulrich A Walker, Andrew Cope, Francesco Dazzi, Cosimo De Bari, Willem Fibbe, Serena Guiducci, Simon Jones, Christian Jorgensen, Katarina Le Blanc, Frank Luyten, Dennis McGonagle, Ivan Martin, Chiara Bocelli-Tyndall, Giuseppina Pennesi, Vito Pistoia, Constantino Pitzalis, Antonio Uccelli, Nico Wulffraat, Marc Feldmann

Published in: Arthritis Research & Therapy | Issue 1/2007

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Abstract

Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently being studied to determine their potential role in the pathogenesis and/or management of autoimmune diseases. In vitro studies have shown that they exhibit a dose-dependent antiproliferative effect on T and B lymphocytes, dendritic cells, natural killer cells and various B cell tumour lines – an effect that is both cell contact and soluble factor dependent. Animal models of autoimmune disease treated with multipotent mesenchymal stromal cells have mostly exhibited a positive clinical response, as have a limited number of patients suffering from acute graft versus host disease. This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts.
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Metadata
Title
Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
Authors
Alan Tyndall
Ulrich A Walker
Andrew Cope
Francesco Dazzi
Cosimo De Bari
Willem Fibbe
Serena Guiducci
Simon Jones
Christian Jorgensen
Katarina Le Blanc
Frank Luyten
Dennis McGonagle
Ivan Martin
Chiara Bocelli-Tyndall
Giuseppina Pennesi
Vito Pistoia
Constantino Pitzalis
Antonio Uccelli
Nico Wulffraat
Marc Feldmann
Publication date
01-02-2007
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2007
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2103

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