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Published in:

01-10-2006 | Review

The role of leptin in innate and adaptive immune responses

Authors: Eiva Bernotiene, Gaby Palmer, Cem Gabay

Published in: Arthritis Research & Therapy | Issue 5/2006

Abstract

Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans.

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Title: The role of leptin in innate and adaptive immune responses
Authors: Eiva Bernotiene
Gaby Palmer
Cem Gabay
Publication date: 01-10-2006
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 5/2006
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2004

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The role of leptin in innate and adaptive immune responses

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