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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2006

01-07-2006 | Review

Interleukin-6 and chronic inflammation

Author: Cem Gabay

Published in: Arthritis Research & Therapy | Special Issue 2/2006

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Abstract

Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase proteins. IL-6 in combination with its soluble receptor sIL-6Rα, dictates the transition from acute to chonic inflammation by changing the nature of leucocyte infiltrate (from polymorphonuclear neutrophils to monocyte/macrophages). In addition, IL-6 exerts stimulatory effects on T- and B-cells, thus favoring chronic inflammatory responses. Strategies targeting IL-6 and IL-6 signaling led to effective prevention and treatment of models of rheumatoid arthritis and other chronic inflammatory diseases.
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Metadata
Title
Interleukin-6 and chronic inflammation
Author
Cem Gabay
Publication date
01-07-2006
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 2/2006
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1917

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