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01-02-2005 | Review

Osteoclasts; culprits in inflammatory osteolysis

Author: Steven L Teitelbaum

Published in: Arthritis Research & Therapy | Issue 1/2006

Abstract

Periarticular osteolysis, a crippling complication of rheumatoid arthritis, is the product of enhanced osteoclast recruitment and activation. The osteoclast, which is a member of the monocyte/macrophage family, is the exclusive bone resorptive cell, and its differentiation and activation are under the aegis of a variety of cytokines. Receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating factor are the essential osteoclastogenic cytokines and are increased in inflammatory joint disease. Tumor necrosis factor-α, which perpetrates arthritic bone loss, exerts its osteoclastogenic effect in the context of RANKL with which it synergizes. Achieving an understanding of the mechanisms by which the three cytokines affect the osteoclast has resulted in a number of active and candidate therapeutic targets.

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Title: Osteoclasts; culprits in inflammatory osteolysis
Author: Steven L Teitelbaum
Publication date: 01-02-2005
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 1/2006
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1857

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