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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2005

01-03-2005 | Review

Negative regulation of cytokine signaling and immune responses by SOCS proteins

Authors: Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada

Published in: Arthritis Research & Therapy | Issue 3/2005

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Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.
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Metadata
Title
Negative regulation of cytokine signaling and immune responses by SOCS proteins
Authors
Akihiko Yoshimura
Hitomi Nishinakamura
Yumiko Matsumura
Toshikatsu Hanada
Publication date
01-03-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1741

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