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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2005

01-03-2005 | Review

The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis

Authors: Eric M Ruderman, Richard M Pope

Published in: Arthritis Research & Therapy | Special Issue 2/2005

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Abstract

Abatacept (CTLA4–Ig) is a novel fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Clinical trials have provided preliminary evidence of the efficacy of this compound in the treatment of rheumatoid arthritis. This review describes the molecular and biologic bases for the use of abatacept in rheumatoid arthritis and summarizes the current clinical data on its safety and effectiveness in this disease.
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Metadata
Title
The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
Authors
Eric M Ruderman
Richard M Pope
Publication date
01-03-2005
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 2/2005
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1688
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