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Open Access 01-06-1999 | Research article

The effects of 1α,25-dihydroxyvitamin D₃ on matrix metalloproteinase and prostaglandin E₂ production by cells of the rheumatoid lesion

Authors: Lynne C Tetlow, David E Woolley

Published in: Arthritis Research & Therapy | Issue 1/1999

Statement of findings

The biologically active metabolite of vitamin D₃, 1α,25-dihydroxyvitamin D₃ [1α,25(OH)₂D₃], acts through vitamin D receptors, which were found in rheumatoid tissues in the present study. IL-1β-activated rheumatoid synovial fibroblasts and human articular chondrocytes were shown to respond differently to exposure to 1α,25(OH)₂D₃, which has different effects on the regulatory pathways of specific matrix metalloproteinases and prostaglandin E₂.

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Title: The effects of 1α,25-dihydroxyvitamin D3 on matrix metalloproteinase and prostaglandin E2 production by cells of the rheumatoid lesion
Authors: Lynne C Tetlow
David E Woolley
Publication date: 01-06-1999
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 1/1999
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar12

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