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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2004

01-08-2004 | Review

Signaling by STATs

Authors: Lionel B Ivashkiv, Xiaoyu Hu

Published in: Arthritis Research & Therapy | Issue 4/2004

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Abstract

A variety of cytokines and growth factors use the Janus kinase (Jak)–STAT signaling pathway to transmit extracellular signals to the nucleus. STATs (signal transducers and activators of transcription) are latent cytoplasmic transcription factors. There are seven mammalian STATs and they have critical, nonredundant roles in mediating cellular transcriptional responses to cytokines. The physiological roles of STATs have been elucidated by analysis of mice rendered deficient in STAT genes. STAT activation is regulated and can be modulated in a positive or negative fashion; it can be reprogrammed to drive different cellular responses. Several auto-regulatory and signaling crosstalk mechanisms for regulating Jak–STAT signaling have been described. Understanding and manipulation of the function of STATs will help in the development of therapeutic strategies for diseases that are regulated by cytokines.
Appendix
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Metadata
Title
Signaling by STATs
Authors
Lionel B Ivashkiv
Xiaoyu Hu
Publication date
01-08-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1197

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