Skip to main content
Top
Published in: Multidisciplinary Respiratory Medicine 1/2013

Open Access 01-12-2013 | Original research article

A pulmonary rehabilitation program reduces levels of anxiety and depression inCOPD patients

Authors: Athanasios Tselebis, Dionisios Bratis, Argiro Pachi, Georgios Moussas, Ioannis Ilias, Maria Harikiopoulou, Elpida Theodorakopoulou, Silvia Dumitru, Epaminondas Kosmas, Alexandros Vgontzas, Nikolaos Siafakas, Nikolaos Tzanakis

Published in: Multidisciplinary Respiratory Medicine | Issue 1/2013

Login to get access

Abstract

Background

The presence of anxiety and depressive symptoms in COPD patients has beenacknowledged for many years. The preponderance of recent studies supportsthe utility of pulmonary rehabilitation programs to reduce the levels ofdepression and anxiety in these patients. The aim of this study is toinvestigate possible changes in levels of anxiety and depression amongpatients enrolled in a pulmonary rehabilitation program, along with the roleof disease severity in these changes.

Methods

In 101 COPD patients, who attended a pulmonary rehabilitation program, levelsof trait anxiety (STAI) and depressive symptoms (BDI) were assessed at thebeginning and at the end of the program. Age, sex, level of education inyears and stage of disease severity were recorded.

Results

Our study included 80 male and 21 female patients. Mean age and meaneducation level were 64.1 ± 8.1 and11.3 ± 4.1 years, respectively. Regarding COPDstaging, 11 patients suffered from mild, 16 from moderate, 47 from severeand 27 from very severe COPD. Significant decreases in anxiety (from 39.7 to34.0, p < 0.001) and depression rates (from 10.7 to 6.3,p < 0.001) were observed. A statistically significantreduction in anxiety and depression was revealed (p < 0.05)atall stages of COPD.

Conclusion

Pulmonary rehabilitation programs should be offered to all COPD patientsirrespective of disease severity, since they all lead to improvement inanxiety and depressive symptoms.
Literature
1.
go back to reference Moussas G, Tselebis A, Karkanias A, Stamouli D, Ilias I, Bratis D, Vassila-Demi K: A comparative study of anxiety and depression in patients with bronchialasthma, chronic obstructive pulmonary disease and tuberculosis in a generalhospital of chest diseases. Ann Gen Psychiatry. 2008, 7: 7-10.1186/1744-859X-7-7.PubMedCentralCrossRefPubMed Moussas G, Tselebis A, Karkanias A, Stamouli D, Ilias I, Bratis D, Vassila-Demi K: A comparative study of anxiety and depression in patients with bronchialasthma, chronic obstructive pulmonary disease and tuberculosis in a generalhospital of chest diseases. Ann Gen Psychiatry. 2008, 7: 7-10.1186/1744-859X-7-7.PubMedCentralCrossRefPubMed
2.
go back to reference Yohannes AM, Willgoss TG, Baldwin RC, Connolly MJ: Depression and anxiety in chronic heart failure and chronic obstructivepulmonary disease: prevalence, relevance, clinical implications andmanagement principles. Int J Geriatr Psychiatry. 2010, 25: 1209-1221. 10.1002/gps.2463.CrossRefPubMed Yohannes AM, Willgoss TG, Baldwin RC, Connolly MJ: Depression and anxiety in chronic heart failure and chronic obstructivepulmonary disease: prevalence, relevance, clinical implications andmanagement principles. Int J Geriatr Psychiatry. 2010, 25: 1209-1221. 10.1002/gps.2463.CrossRefPubMed
3.
go back to reference Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik ME, Yohannes AM, Hanania NA, ACCP Workshop Panel on Anxiety and Depression in COPD: Anxiety and depression in COPD: current understanding, unanswered questions,and research needs. Chest. 2008, 134 suppl: 43S-56S.CrossRef Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik ME, Yohannes AM, Hanania NA, ACCP Workshop Panel on Anxiety and Depression in COPD: Anxiety and depression in COPD: current understanding, unanswered questions,and research needs. Chest. 2008, 134 suppl: 43S-56S.CrossRef
4.
go back to reference Wells KB, Golding J, Burnan MA: Psychiatric disorder in a sample of the general population with and withoutchronic medical conditions. Am J Psychiatry. 1998, 145: 976-979. Wells KB, Golding J, Burnan MA: Psychiatric disorder in a sample of the general population with and withoutchronic medical conditions. Am J Psychiatry. 1998, 145: 976-979.
5.
go back to reference Tselebis A, Gournas G, Tzitzanidou G, Panagiotou A, Ilias I: Anxiety and depression in Greek nursing and medical personnel. Psychol Rep. 2006, 99: 93-96.PubMed Tselebis A, Gournas G, Tzitzanidou G, Panagiotou A, Ilias I: Anxiety and depression in Greek nursing and medical personnel. Psychol Rep. 2006, 99: 93-96.PubMed
6.
go back to reference Tselebis A, Bratis D, Kosmas E, Harikiopoulou M, Theodorakopoulou E, Dumitru S, Moussas G, Karkanias A, Ilias I, Siafakas N, Vgontzas A, Tzanakis N: Psychological symptom patterns and vital exhaustion in outpatients withchronic obstructive pulmonary disease. Ann Gen Psychiatry. 2011, 10: 32-10.1186/1744-859X-10-32.PubMedCentralCrossRefPubMed Tselebis A, Bratis D, Kosmas E, Harikiopoulou M, Theodorakopoulou E, Dumitru S, Moussas G, Karkanias A, Ilias I, Siafakas N, Vgontzas A, Tzanakis N: Psychological symptom patterns and vital exhaustion in outpatients withchronic obstructive pulmonary disease. Ann Gen Psychiatry. 2011, 10: 32-10.1186/1744-859X-10-32.PubMedCentralCrossRefPubMed
7.
go back to reference Emery CF, Schein RL, Hauck ER, MacIntyre NR: Psychosocial and cognitive outcomes of a randomized trial of exercise amongpatients with chronic obstructive pulmonary disease. Health Psychol. 1998, 17: 232-240.CrossRefPubMed Emery CF, Schein RL, Hauck ER, MacIntyre NR: Psychosocial and cognitive outcomes of a randomized trial of exercise amongpatients with chronic obstructive pulmonary disease. Health Psychol. 1998, 17: 232-240.CrossRefPubMed
8.
go back to reference Griffiths TL, Burr ML, Campbell IA, Lewis-Jenkins V, Mullins J, Shiels K, Turner-Lawlor PJ, Payne N, Newcombe RG, Ionescu AA, Thomas J, Tunbridge J: Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: arandomised controlled trial. Lancet. 2000, 355: 362-368. 10.1016/S0140-6736(99)07042-7.CrossRefPubMed Griffiths TL, Burr ML, Campbell IA, Lewis-Jenkins V, Mullins J, Shiels K, Turner-Lawlor PJ, Payne N, Newcombe RG, Ionescu AA, Thomas J, Tunbridge J: Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: arandomised controlled trial. Lancet. 2000, 355: 362-368. 10.1016/S0140-6736(99)07042-7.CrossRefPubMed
9.
go back to reference Guell R, Resqueti V, Sangenis M, Morante F, Martorell B, Casan P, Guyatt GH: Impact of pulmonary rehabilitation on psychosocial morbidity in patients withsevere COPD. Chest. 2006, 129: 899-904. 10.1378/chest.129.4.899.CrossRefPubMed Guell R, Resqueti V, Sangenis M, Morante F, Martorell B, Casan P, Guyatt GH: Impact of pulmonary rehabilitation on psychosocial morbidity in patients withsevere COPD. Chest. 2006, 129: 899-904. 10.1378/chest.129.4.899.CrossRefPubMed
10.
go back to reference Ries AL, Bauldoff GS, Carlin BW, Casaburi R, Emery CF, Mahler DA, Make B, Rochester CL, Zuwallack R, Herrerias C: Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical PracticeGuidelines. Chest. 2007, 131 (5 Suppl): 4S-42S.CrossRefPubMed Ries AL, Bauldoff GS, Carlin BW, Casaburi R, Emery CF, Mahler DA, Make B, Rochester CL, Zuwallack R, Herrerias C: Pulmonary Rehabilitation: Joint ACCP/AACVPR Evidence-Based Clinical PracticeGuidelines. Chest. 2007, 131 (5 Suppl): 4S-42S.CrossRefPubMed
11.
go back to reference Güell R, Resqueti V, Sangenis M, Morante F, Martorell B, Casan P, Guyatt GH: Impact of pulmonary rehabilitation on psychosocial morbidity in patients withsevere COPD. Chest. 2006, 129: 899-904. 10.1378/chest.129.4.899.CrossRefPubMed Güell R, Resqueti V, Sangenis M, Morante F, Martorell B, Casan P, Guyatt GH: Impact of pulmonary rehabilitation on psychosocial morbidity in patients withsevere COPD. Chest. 2006, 129: 899-904. 10.1378/chest.129.4.899.CrossRefPubMed
12.
go back to reference Withers NJ, Rudkin ST, White RJ: Anxiety and depression in severe chronic obstructive pulmonary disease: theeffects ofpulmonary rehabilitation. J Cardiopulm Rehabil. 1999, 19: 362-365. 10.1097/00008483-199911000-00007.CrossRefPubMed Withers NJ, Rudkin ST, White RJ: Anxiety and depression in severe chronic obstructive pulmonary disease: theeffects ofpulmonary rehabilitation. J Cardiopulm Rehabil. 1999, 19: 362-365. 10.1097/00008483-199911000-00007.CrossRefPubMed
13.
go back to reference Hui KP, Hewitt AB: A simple pulmonary rehabilitation program improves health outcomes andreduces hospital utilization in patients with COPD. Chest. 2003, 124: 94-97. 10.1378/chest.124.1.94.CrossRefPubMed Hui KP, Hewitt AB: A simple pulmonary rehabilitation program improves health outcomes andreduces hospital utilization in patients with COPD. Chest. 2003, 124: 94-97. 10.1378/chest.124.1.94.CrossRefPubMed
14.
go back to reference Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management, and Prevention of ChronicObstructive Pulmonary Disease (GOLD).http://www.goldcopd.org, Global Initiative for Chronic Obstructive Lung Disease: Global Strategy for the Diagnosis, Management, and Prevention of ChronicObstructive Pulmonary Disease (GOLD).http://​www.​goldcopd.​org,
15.
go back to reference Beck AT, Steer RA: Manual for the Revised Beck Depression Inventory. 1987, San Antonio, TX: Psychological Corporation Beck AT, Steer RA: Manual for the Revised Beck Depression Inventory. 1987, San Antonio, TX: Psychological Corporation
16.
go back to reference Donias S, Demertzis I: Validation of the Beck depression inventory. Proceedings of the 10th Hellenic Congress of Neurology and Psychiatry:1983. Edited by: Varfis G. 1983, Thessaloniki, Greece: University Studio Press, 486-492. Donias S, Demertzis I: Validation of the Beck depression inventory. Proceedings of the 10th Hellenic Congress of Neurology and Psychiatry:1983. Edited by: Varfis G. 1983, Thessaloniki, Greece: University Studio Press, 486-492.
17.
go back to reference Tselebis A, Moulou A, Ilias I: Burnout versus depression and sense of coherence: A study in Greek nursingstaff. Nurs Health Sci. 2001, 3: 69-71. 10.1046/j.1442-2018.2001.00074.x.CrossRefPubMed Tselebis A, Moulou A, Ilias I: Burnout versus depression and sense of coherence: A study in Greek nursingstaff. Nurs Health Sci. 2001, 3: 69-71. 10.1046/j.1442-2018.2001.00074.x.CrossRefPubMed
18.
go back to reference Spielberger GD, Gorush RL, Lusshene RE: The State-Trait Anxiety Inventory. 1970, Palo Alto, CA: Consulting Psychologists Press Spielberger GD, Gorush RL, Lusshene RE: The State-Trait Anxiety Inventory. 1970, Palo Alto, CA: Consulting Psychologists Press
19.
go back to reference Liakos A, Giannitsi S: The validity of the Greek modification of the Spielberger anxiety scale. Encephalos. 1984, 21: 71-76. Liakos A, Giannitsi S: The validity of the Greek modification of the Spielberger anxiety scale. Encephalos. 1984, 21: 71-76.
20.
go back to reference Tselebis A, Papaleftheris E, Balis E, Theotoka I, Ilias I: Smoking related to anxiety and depression in Greek medical staff. Psychol Rep. 2003, 92: 529-532. 10.2466/pr0.2003.92.2.529.CrossRefPubMed Tselebis A, Papaleftheris E, Balis E, Theotoka I, Ilias I: Smoking related to anxiety and depression in Greek medical staff. Psychol Rep. 2003, 92: 529-532. 10.2466/pr0.2003.92.2.529.CrossRefPubMed
21.
go back to reference Di Marco F, Verga M, Reggente M, Maria Casanova F, Santus P, Blasi F, Allegra L, Centanni S: Anxiety and depression in COPD patients: the roles of gender and diseaseseverity. Respir Med. 2006, 100: 1767-1774. 10.1016/j.rmed.2006.01.026.CrossRefPubMed Di Marco F, Verga M, Reggente M, Maria Casanova F, Santus P, Blasi F, Allegra L, Centanni S: Anxiety and depression in COPD patients: the roles of gender and diseaseseverity. Respir Med. 2006, 100: 1767-1774. 10.1016/j.rmed.2006.01.026.CrossRefPubMed
22.
go back to reference Voekel M, Voelkel NF, MacNee W: Chronic Obstructive Lung Diseases 2. Psychosocial aspects of ChronicObstructive Pulmonary Disease. 2008, BC Decker Inc: City, Voekel M, Voelkel NF, MacNee W: Chronic Obstructive Lung Diseases 2. Psychosocial aspects of ChronicObstructive Pulmonary Disease. 2008, BC Decker Inc: City,
23.
go back to reference Man GCW, Hsu K, Spoule BJ: Effect of alprazolam on exercise and dyspnea in patients with chronicobstructive pulmonary disease. Chest. 1986, 90: 832-836. 10.1378/chest.90.6.832.CrossRefPubMed Man GCW, Hsu K, Spoule BJ: Effect of alprazolam on exercise and dyspnea in patients with chronicobstructive pulmonary disease. Chest. 1986, 90: 832-836. 10.1378/chest.90.6.832.CrossRefPubMed
24.
go back to reference Cantor L, Jacobson R: COPD: How to manage comorbid depression and anxiety. J Fam Pract. 2003, 2: 11- Cantor L, Jacobson R: COPD: How to manage comorbid depression and anxiety. J Fam Pract. 2003, 2: 11-
25.
go back to reference Mikkelsen RL, Middelboe T, Pisinger C, Stage KB: Anxiety and depression in patients with chronic obstructive pulmonary disease(COPD). A review. Nord J Psychiatry. 2004, 58: 65-70. 10.1080/08039480310000824.CrossRefPubMed Mikkelsen RL, Middelboe T, Pisinger C, Stage KB: Anxiety and depression in patients with chronic obstructive pulmonary disease(COPD). A review. Nord J Psychiatry. 2004, 58: 65-70. 10.1080/08039480310000824.CrossRefPubMed
26.
go back to reference Yohannes AM, Connolly MJ, Baldwin RC: A feasibility study of antidepressant drug therapy in depressed elderlypatients with chronic obstructive pulmonary disease. Int J Geriatr Psychiatry. 2001, 16: 451-454. 10.1002/gps.461.CrossRefPubMed Yohannes AM, Connolly MJ, Baldwin RC: A feasibility study of antidepressant drug therapy in depressed elderlypatients with chronic obstructive pulmonary disease. Int J Geriatr Psychiatry. 2001, 16: 451-454. 10.1002/gps.461.CrossRefPubMed
27.
go back to reference Eiser N, Harte R, Spiros K: Effect of treating depression on quality-of-life and exercise tolerance insevere COPD. COPD. 2005, 2: 233-241. 10.1081/COPD-57596.CrossRefPubMed Eiser N, Harte R, Spiros K: Effect of treating depression on quality-of-life and exercise tolerance insevere COPD. COPD. 2005, 2: 233-241. 10.1081/COPD-57596.CrossRefPubMed
28.
go back to reference Papp LA, Weiss JR, Greenberg HE, Rifkin A, Scharf SM, Gorman JM, Klein DF: Sertraline for chronic obstructive pulmonary disease and comorbid anxiety andmood disorders. Am J Psychiatry. 1995, 152: 1531-PubMed Papp LA, Weiss JR, Greenberg HE, Rifkin A, Scharf SM, Gorman JM, Klein DF: Sertraline for chronic obstructive pulmonary disease and comorbid anxiety andmood disorders. Am J Psychiatry. 1995, 152: 1531-PubMed
29.
go back to reference Smoller JW, Pollack MH, Systrom D, Kradin RL: Sertraline effects on dyspnea in patients with obstructive airwaysdisease. Psychosomatics. 1998, 39: 24-29. 10.1016/S0033-3182(98)71377-5.CrossRefPubMed Smoller JW, Pollack MH, Systrom D, Kradin RL: Sertraline effects on dyspnea in patients with obstructive airwaysdisease. Psychosomatics. 1998, 39: 24-29. 10.1016/S0033-3182(98)71377-5.CrossRefPubMed
30.
go back to reference Lacasse Y, Beaudoin L, Rousseau L, Maltais F: Randomized trial of paroxetine in end-stage COPD. Monaldi Arch Chest Dis. 2004, 61: 140-147.PubMed Lacasse Y, Beaudoin L, Rousseau L, Maltais F: Randomized trial of paroxetine in end-stage COPD. Monaldi Arch Chest Dis. 2004, 61: 140-147.PubMed
31.
go back to reference Evans M, Hammond M, Wilson K, Lye M, Copeland J: Placebo controlled treatment trial of depression in elderly physically illpatients. Int J Geriatr Psychiatry. 1997, 12: 817-824. 10.1002/(SICI)1099-1166(199708)12:8<817::AID-GPS645>3.0.CO;2-4.CrossRefPubMed Evans M, Hammond M, Wilson K, Lye M, Copeland J: Placebo controlled treatment trial of depression in elderly physically illpatients. Int J Geriatr Psychiatry. 1997, 12: 817-824. 10.1002/(SICI)1099-1166(199708)12:8<817::AID-GPS645>3.0.CO;2-4.CrossRefPubMed
32.
go back to reference Silvertooth EJ, Doraiswamy PM, Clary GL, Babyak MA, Wilkerson N, Hellegars C, Palmer SM: Citalopram and quality of life in lung transplant recipients. Psychosomatics. 2004, 45: 271-272. 10.1176/appi.psy.45.3.271.CrossRefPubMed Silvertooth EJ, Doraiswamy PM, Clary GL, Babyak MA, Wilkerson N, Hellegars C, Palmer SM: Citalopram and quality of life in lung transplant recipients. Psychosomatics. 2004, 45: 271-272. 10.1176/appi.psy.45.3.271.CrossRefPubMed
33.
go back to reference Yohannes AM, Connolly MJ: Do antidepressants work in patients with chronic obstructive pulmonarydisease with comorbid depression?. Expert Rev Respir Med. 2011, 5 (6): 727-729. 10.1586/ers.11.70.CrossRefPubMed Yohannes AM, Connolly MJ: Do antidepressants work in patients with chronic obstructive pulmonarydisease with comorbid depression?. Expert Rev Respir Med. 2011, 5 (6): 727-729. 10.1586/ers.11.70.CrossRefPubMed
34.
go back to reference Post L, Collins C: The poorly coping COPD patient: a psychotherapeutic perspective. Int J Psychiatry Med. 1981–1982, 11 (2): 173-182. 10.2190/VUVV-2RQV-AG30-DPL1.CrossRef Post L, Collins C: The poorly coping COPD patient: a psychotherapeutic perspective. Int J Psychiatry Med. 1981–1982, 11 (2): 173-182. 10.2190/VUVV-2RQV-AG30-DPL1.CrossRef
35.
go back to reference Kunik ME, Braun U, Stanley MA, Wristers K, Molinari V, Stoebner D, Orengo CA: One session cognitive behavioural therapy for elderly patients with chronicobstructive pulmonary disease. Psychol Med. 2001, 31: 717-723.CrossRefPubMed Kunik ME, Braun U, Stanley MA, Wristers K, Molinari V, Stoebner D, Orengo CA: One session cognitive behavioural therapy for elderly patients with chronicobstructive pulmonary disease. Psychol Med. 2001, 31: 717-723.CrossRefPubMed
36.
go back to reference Eiser N, West C, Evans S, Jeffers A, Quirk F: Effects of psychotherapy in moderately severe COPD: a pilot study. Eur Respir J. 1997, 10: 1581-1584. 10.1183/09031936.97.10071581.CrossRefPubMed Eiser N, West C, Evans S, Jeffers A, Quirk F: Effects of psychotherapy in moderately severe COPD: a pilot study. Eur Respir J. 1997, 10: 1581-1584. 10.1183/09031936.97.10071581.CrossRefPubMed
37.
go back to reference de Godoy DV, de Godoy RF: A randomized controlled trial of the effect of psychotherapy on anxiety anddepression in chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2003, 84: 1154-1157. 10.1016/S0003-9993(03)00239-9.CrossRefPubMed de Godoy DV, de Godoy RF: A randomized controlled trial of the effect of psychotherapy on anxiety anddepression in chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2003, 84: 1154-1157. 10.1016/S0003-9993(03)00239-9.CrossRefPubMed
38.
go back to reference Kunik ME, Veazey C, Cully JA, Souchek J, Graham DP, Hopko D, Carter R, Sharafkhaneh A, Goepfert EJ, Wray N, Stanley MA: COPD education and cognitive behavioral therapy group treatment forclinically significant symptoms of depression and anxiety in COPD patients;a randomized controlled trial. Psychol Med. 2008, 38: 385-396.CrossRefPubMed Kunik ME, Veazey C, Cully JA, Souchek J, Graham DP, Hopko D, Carter R, Sharafkhaneh A, Goepfert EJ, Wray N, Stanley MA: COPD education and cognitive behavioral therapy group treatment forclinically significant symptoms of depression and anxiety in COPD patients;a randomized controlled trial. Psychol Med. 2008, 38: 385-396.CrossRefPubMed
40.
go back to reference Dishman RK: Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sports Exerc. 1997, 29 (1): 63-74. 10.1097/00005768-199701000-00010.CrossRefPubMed Dishman RK: Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sports Exerc. 1997, 29 (1): 63-74. 10.1097/00005768-199701000-00010.CrossRefPubMed
41.
go back to reference Ransford CP: A role for amines in the antidepressant effect of exercise: a review. Med Sci Sports Exerc. 1982, 14 (1): 1-10. 10.1249/00005768-198201000-00001.CrossRefPubMed Ransford CP: A role for amines in the antidepressant effect of exercise: a review. Med Sci Sports Exerc. 1982, 14 (1): 1-10. 10.1249/00005768-198201000-00001.CrossRefPubMed
42.
go back to reference Dunn AL, Reigle TG, Youngstedt SD, Armstrong RB, Dishman RK: Brain norepinephrine and metabolites after treadmill training and wheelrunning in rats. Med Sci Sports Exerc. 1996, 28 (2): 204-209. 10.1097/00005768-199602000-00008.CrossRefPubMed Dunn AL, Reigle TG, Youngstedt SD, Armstrong RB, Dishman RK: Brain norepinephrine and metabolites after treadmill training and wheelrunning in rats. Med Sci Sports Exerc. 1996, 28 (2): 204-209. 10.1097/00005768-199602000-00008.CrossRefPubMed
43.
go back to reference Jacobs BL: Serotonin, motor activity and depression-related disorders. Am Sci. 1994, 82: 456-463. Jacobs BL: Serotonin, motor activity and depression-related disorders. Am Sci. 1994, 82: 456-463.
44.
go back to reference Chaouloff F: Effects of acute exercise on central serotonergic systems. Med Sci Sports Exerc. 1997, 29 (1): 58-62. 10.1097/00005768-199701000-00009.CrossRefPubMed Chaouloff F: Effects of acute exercise on central serotonergic systems. Med Sci Sports Exerc. 1997, 29 (1): 58-62. 10.1097/00005768-199701000-00009.CrossRefPubMed
45.
go back to reference Raglin JS, Morgan WP: Influence of exercise and quiet rest on state anxiety and blood pressure. Med Sci Sports Exerc. 1981, 19 (5): 456-463. Raglin JS, Morgan WP: Influence of exercise and quiet rest on state anxiety and blood pressure. Med Sci Sports Exerc. 1981, 19 (5): 456-463.
46.
go back to reference Carr DB, Bullen BA, Skrinar GS, Arnold MA, Rosenblatt M, Beitins IZ, Martin JB, McArthur JW: Physical conditioning facilitates the exercise-induced secretion ofbeta-endorphin and beta-lipotropin in women. N Engl J Med. 1981, 305 (10): 560-563. 10.1056/NEJM198109033051006.CrossRefPubMed Carr DB, Bullen BA, Skrinar GS, Arnold MA, Rosenblatt M, Beitins IZ, Martin JB, McArthur JW: Physical conditioning facilitates the exercise-induced secretion ofbeta-endorphin and beta-lipotropin in women. N Engl J Med. 1981, 305 (10): 560-563. 10.1056/NEJM198109033051006.CrossRefPubMed
47.
go back to reference Farrell PA, Gates WK, Maksud MG, Morgan WP: Increases in plasma beta endorphin/beta-lipotropinimmunoreactivity aftertreadmillrunning in humans. J Appl Physiol. 1982, 52 (5): 1245-1249.PubMed Farrell PA, Gates WK, Maksud MG, Morgan WP: Increases in plasma beta endorphin/beta-lipotropinimmunoreactivity aftertreadmillrunning in humans. J Appl Physiol. 1982, 52 (5): 1245-1249.PubMed
48.
go back to reference Gambert SR, Hagen TC, Garthwaite TL: Exercise and the endogenous opioids. N Engl J Med. 1981, 305: 1590-1591.CrossRef Gambert SR, Hagen TC, Garthwaite TL: Exercise and the endogenous opioids. N Engl J Med. 1981, 305: 1590-1591.CrossRef
49.
go back to reference Pitsavos C, Chrysohoou C, Panagiotakos DB, Skoumas J, Zeimbekis A, Kokkinos P, Stefanadis C, Toutouzas PK: Association of leisure-time physical activity on inflammation markers(C-reactive protein, white cell blood count, serum amyloid A, andfibrinogen) in healthy subjects (from the ATTICA study). Am J Cardiol. 2003, 91 (3): 368-370. 10.1016/S0002-9149(02)03175-2.CrossRefPubMed Pitsavos C, Chrysohoou C, Panagiotakos DB, Skoumas J, Zeimbekis A, Kokkinos P, Stefanadis C, Toutouzas PK: Association of leisure-time physical activity on inflammation markers(C-reactive protein, white cell blood count, serum amyloid A, andfibrinogen) in healthy subjects (from the ATTICA study). Am J Cardiol. 2003, 91 (3): 368-370. 10.1016/S0002-9149(02)03175-2.CrossRefPubMed
50.
go back to reference Church TS, Barlow CE, Earnest CP, Kampert JB, Priest EL, Blair SN: Associations between cardiorespiratory fitness and C-reactive protein inmen. Arterioscler Thomb Vasc Biol. 2002, 22 (11): 1869-1876. 10.1161/01.ATV.0000036611.77940.F8.CrossRef Church TS, Barlow CE, Earnest CP, Kampert JB, Priest EL, Blair SN: Associations between cardiorespiratory fitness and C-reactive protein inmen. Arterioscler Thomb Vasc Biol. 2002, 22 (11): 1869-1876. 10.1161/01.ATV.0000036611.77940.F8.CrossRef
51.
go back to reference Morrow J, Nolen-Hoeksema S: Effects of response to depression on the remediation of depressive affect. J Pers Soc Psychol. 1990, 58 (3): 519-527.CrossRefPubMed Morrow J, Nolen-Hoeksema S: Effects of response to depression on the remediation of depressive affect. J Pers Soc Psychol. 1990, 58 (3): 519-527.CrossRefPubMed
52.
go back to reference Nolen-Hoeksema S, Morrow J: A prospective study of depression and posttraumatic stress symptoms after anatural disaster: the 1989 Loma Prieta earthquake. J Pers Soc Psychol. 1991, 61 (1): 115-121.CrossRefPubMed Nolen-Hoeksema S, Morrow J: A prospective study of depression and posttraumatic stress symptoms after anatural disaster: the 1989 Loma Prieta earthquake. J Pers Soc Psychol. 1991, 61 (1): 115-121.CrossRefPubMed
53.
go back to reference McAuley E, Jerome GJ, Marquez DX, Elavsky S, Blissmer B: Exercise self-efficacy in older adults: social, affective, and behavioralinfluences. Ann Behav Med. 2003, 25 (1): 1-7. 10.1207/S15324796ABM2501_01.CrossRefPubMed McAuley E, Jerome GJ, Marquez DX, Elavsky S, Blissmer B: Exercise self-efficacy in older adults: social, affective, and behavioralinfluences. Ann Behav Med. 2003, 25 (1): 1-7. 10.1207/S15324796ABM2501_01.CrossRefPubMed
54.
go back to reference Craft LL: Exercise and clinical depression: examining two psychological mechanisms. Psychol Sport Exerc. 2003, 6: 151-171.CrossRef Craft LL: Exercise and clinical depression: examining two psychological mechanisms. Psychol Sport Exerc. 2003, 6: 151-171.CrossRef
55.
go back to reference Lewinsohn PM, Gotlib IH: Behavioral theory and treatment of depression. Handbook of depression. Edited by: Beckham EE, Leber WR. 1995, New York: Guildford Press, 352-375. 2 Lewinsohn PM, Gotlib IH: Behavioral theory and treatment of depression. Handbook of depression. Edited by: Beckham EE, Leber WR. 1995, New York: Guildford Press, 352-375. 2
56.
go back to reference Bartoholomew JB, Ciccolo JT: Exercise, depression, and cognition. Exercise and its mediating effects on cognition. Edited by: Spirduso WW, Poon LW, Chodzko-Zajko W. 2008, Champaign, IL: Human Kinetcs, 2 Bartoholomew JB, Ciccolo JT: Exercise, depression, and cognition. Exercise and its mediating effects on cognition. Edited by: Spirduso WW, Poon LW, Chodzko-Zajko W. 2008, Champaign, IL: Human Kinetcs, 2
57.
go back to reference Tselebis A, Moussas G, Bratis D: Psychological intervention in a COPD rehabilitation programme [in ModernGreek]. Pneumonologika Themata. 2006, 21-23. Tselebis A, Moussas G, Bratis D: Psychological intervention in a COPD rehabilitation programme [in ModernGreek]. Pneumonologika Themata. 2006, 21-23.
58.
go back to reference Lacasse Y, Maltais F, Goldstein RS: Pulmonary rehabilitation: an integral part of the long-term management ofCOPD. Swiss Med Wkly. 2004, 134 (41–42): 601-605.PubMed Lacasse Y, Maltais F, Goldstein RS: Pulmonary rehabilitation: an integral part of the long-term management ofCOPD. Swiss Med Wkly. 2004, 134 (41–42): 601-605.PubMed
59.
go back to reference Paz-Dıaz H, Montes de Oca M, Lopez JM, Celli BR: Pulmonary rehabilitation improves depression, anxiety, dyspnea and healthstatus in patients with COPD. Am J Phys Med Rehabil. 2006, 86 (1): 30-36.CrossRef Paz-Dıaz H, Montes de Oca M, Lopez JM, Celli BR: Pulmonary rehabilitation improves depression, anxiety, dyspnea and healthstatus in patients with COPD. Am J Phys Med Rehabil. 2006, 86 (1): 30-36.CrossRef
60.
go back to reference Pantou I, Harikiopoulou M, Bratis D: European Respiratory Society, Annual Congress. The impact of rehabilitation-induced symptomatic, functional andpsychological outcomes on health-related quality of life. 2006, Pantou I, Harikiopoulou M, Bratis D: European Respiratory Society, Annual Congress. The impact of rehabilitation-induced symptomatic, functional andpsychological outcomes on health-related quality of life. 2006,
61.
go back to reference Coventry PA, Bower P, Keyworth C, Kenning C, Knopp J, Garrett C, Hind D, Malpass A, Dickens C: The effect of complex interventions on depression and anxiety in chronicobstructive pulmonary disease: systematic review and meta-analysis. PLoS One. 2013, 8 (4): e60532-10.1371/journal.pone.0060532.PubMedCentralCrossRefPubMed Coventry PA, Bower P, Keyworth C, Kenning C, Knopp J, Garrett C, Hind D, Malpass A, Dickens C: The effect of complex interventions on depression and anxiety in chronicobstructive pulmonary disease: systematic review and meta-analysis. PLoS One. 2013, 8 (4): e60532-10.1371/journal.pone.0060532.PubMedCentralCrossRefPubMed
62.
go back to reference White RJ, Rudkin ST, Ashley J, Stevens VA, Burrows S, Pounsford JC, Cratchley G, Ambler NR: Outpatient pulmonary rehabilitation in severe chronic obstructive pulmonarydisease. J R Coll Physicians Lond. 1997, 31: 541-545.PubMed White RJ, Rudkin ST, Ashley J, Stevens VA, Burrows S, Pounsford JC, Cratchley G, Ambler NR: Outpatient pulmonary rehabilitation in severe chronic obstructive pulmonarydisease. J R Coll Physicians Lond. 1997, 31: 541-545.PubMed
63.
go back to reference Pantou I, Harikiopoulou M, Mpletsa M: European Respiratory Society, Annual Congress. Does the severity of chronic obstructive pulmonary disease reflect on theoutcomes of pulmonary rehabilitation?. 2007, Pantou I, Harikiopoulou M, Mpletsa M: European Respiratory Society, Annual Congress. Does the severity of chronic obstructive pulmonary disease reflect on theoutcomes of pulmonary rehabilitation?. 2007,
64.
go back to reference Trappenburg JC, Troosters T, Spruit MA, Vandebrouck N, Decramer M, Gosselink R: Psychosocial conditions do not affect short-term outcome of multidisciplinaryrehabilitation in chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2005, 86 (9): 1788-1792. 10.1016/j.apmr.2005.03.030.CrossRefPubMed Trappenburg JC, Troosters T, Spruit MA, Vandebrouck N, Decramer M, Gosselink R: Psychosocial conditions do not affect short-term outcome of multidisciplinaryrehabilitation in chronic obstructive pulmonary disease. Arch Phys Med Rehabil. 2005, 86 (9): 1788-1792. 10.1016/j.apmr.2005.03.030.CrossRefPubMed
65.
go back to reference Edmunds M, Scudder L: Examining the Relationships Between COPD and Anxiety and Depression. Heart Lung. 2009, 38: 34-47. 10.1016/j.hrtlng.2008.02.005.CrossRef Edmunds M, Scudder L: Examining the Relationships Between COPD and Anxiety and Depression. Heart Lung. 2009, 38: 34-47. 10.1016/j.hrtlng.2008.02.005.CrossRef
66.
go back to reference Kunik ME, Roundy K, Veazey C, Souchek J, Richardson P, Wray NP, Stanley MA: Surprisingly high prevalence of anxiety and depression in chronic breathingdisorders. Chest. 2005, 127: 1205-1211. 10.1378/chest.127.4.1205.CrossRefPubMed Kunik ME, Roundy K, Veazey C, Souchek J, Richardson P, Wray NP, Stanley MA: Surprisingly high prevalence of anxiety and depression in chronic breathingdisorders. Chest. 2005, 127: 1205-1211. 10.1378/chest.127.4.1205.CrossRefPubMed
67.
go back to reference Hill K, Geist R, Goldstein RS: Anxiety and depression in end-stage COPD. Eur Respir J. 2008, 31 (3): 667-677. 10.1183/09031936.00125707.CrossRefPubMed Hill K, Geist R, Goldstein RS: Anxiety and depression in end-stage COPD. Eur Respir J. 2008, 31 (3): 667-677. 10.1183/09031936.00125707.CrossRefPubMed
68.
go back to reference Tselebis A, Kosmas E, Bratis D, Moussas G, Karkanias A, Ilias I, Siafakas N, Vgontzas A, Tzanakis N: Prevalence of alexithymia and its association with anxiety and depression ina sample of Greek chronic obstructive pulmonary disease (COPD)outpatients. Ann Gen Psychiatry. 2010, 9: 16-10.1186/1744-859X-9-16.PubMedCentralCrossRefPubMed Tselebis A, Kosmas E, Bratis D, Moussas G, Karkanias A, Ilias I, Siafakas N, Vgontzas A, Tzanakis N: Prevalence of alexithymia and its association with anxiety and depression ina sample of Greek chronic obstructive pulmonary disease (COPD)outpatients. Ann Gen Psychiatry. 2010, 9: 16-10.1186/1744-859X-9-16.PubMedCentralCrossRefPubMed
69.
go back to reference Papaioannou AI, Loukides S, Gourgoulianis KI, Kostikas K: Global assessment of the COPD patient: Time to look beyond FEV1?. Respir Med. 2009, 103: 650-660. 10.1016/j.rmed.2009.01.001.CrossRefPubMed Papaioannou AI, Loukides S, Gourgoulianis KI, Kostikas K: Global assessment of the COPD patient: Time to look beyond FEV1?. Respir Med. 2009, 103: 650-660. 10.1016/j.rmed.2009.01.001.CrossRefPubMed
Metadata
Title
A pulmonary rehabilitation program reduces levels of anxiety and depression inCOPD patients
Authors
Athanasios Tselebis
Dionisios Bratis
Argiro Pachi
Georgios Moussas
Ioannis Ilias
Maria Harikiopoulou
Elpida Theodorakopoulou
Silvia Dumitru
Epaminondas Kosmas
Alexandros Vgontzas
Nikolaos Siafakas
Nikolaos Tzanakis
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Multidisciplinary Respiratory Medicine / Issue 1/2013
Electronic ISSN: 2049-6958
DOI
https://doi.org/10.1186/2049-6958-8-41

Other articles of this Issue 1/2013

Multidisciplinary Respiratory Medicine 1/2013 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.