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Archives of Public Health
Published in: Archives of Public Health 1/2014

Open Access 01-06-2014 | Oral presentation

Role of ciliary dysfunction in a new model of obesity and non-alcoholic steatohepatitis: the foz/fozmice

Authors: Laurence Poekes, Vanessa Legry, Geoffrey Farrell, Isabelle Leclercq

Published in: Archives of Public Health | Special Issue 1/2014

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Excerpt

Foz/foz mice are deficient for Alms1, a ubiquitous protein essential for proper primary cilium function. They are prone to insulin resistance, obesity and diabetes, a phenotype accelerated by high-fat diet (HFD) feeding. Their unique metabolic phenotype has been linked to hyperphagia resulting from abnormal ciliary function in the central nervous system [1]. The aim of our study is to verify the dependence of the phenotype on over-feeding and to explore the role of Alms1 deficiency in intestinal energy absorption. …
Literature
1.
Heydet D, et al: A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Devl Neurobiol. 2012, 73: 1-13.CrossRef
Metadata
Title
Role of ciliary dysfunction in a new model of obesity and non-alcoholic steatohepatitis: the foz/fozmice
Authors
Laurence Poekes
Vanessa Legry
Geoffrey Farrell
Isabelle Leclercq
Publication date
01-06-2014
Publisher
BioMed Central
Published in
Archives of Public Health / Issue Special Issue 1/2014
Electronic ISSN: 2049-3258
DOI
https://doi.org/10.1186/2049-3258-72-S1-O7

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