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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2014

Open Access 01-12-2014 | Meeting abstract

Stellate cells are mesenchymal stem cells

Authors: Claus Kordes, Iris Sawitza, Silke Götze, Diran Herebian, Dieter Häussinger

Published in: European Journal of Medical Research | Special Issue 1/2014

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Excerpt

Vitamin A-storing hepatic stellate cells (HSC) are mainly known for their contribution to fibrogenesis in chronic liver disease, but their identity and function in normal liver remained unclear. Since HSC possess stem/progenitor cell characteristics [1] their contribution to stem cell-associated functions in the liver was investigated. Stem cell functions in the liver were reported during fetal hematopoiesis and tissue repair after severe injury when the proliferation of hepatocytes is impaired. By using several in vitro and in vivo approaches evidence was provided that stellate cells represent mesenchymal stem cells (MSC), which can support hematopoietic stem/progenitor cells in the fetal liver and contribute to the regeneration of injured liver as multipotent adult stem cells. …
Literature
1.
Kordes C, Sawitza I, Müller-Marbach A, Ale-Agha N, Keitel V, Klonowski-Stumpe H, Häussinger D: CD133+ hepatic stellate cells are progenitor cells. Biochem Biophys Res Commun 2007, 352: 410–417. 10.1016/j.bbrc.2006.11.029PubMedCrossRef
2.
Kordes C, Sawitza I, Götze S, Häussinger D: Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells. Cell Physiol Biochem 2013, 31: 290–304. 10.1159/000343368PubMedCrossRef
3.
Kordes C, Sawitza I, Götze S, Häussinger D: Stellate cells from rat pancreas are stem cells and can contribute to liver regeneration. PLoS One 2012, 7: e51878. 10.1371/journal.pone.0051878PubMedCentralPubMedCrossRef
4.
Sawitza I, Kordes C, Reister S, Häussinger D: The niche of stellate cells within rat liver. Hepatology 2009, 50: 1617–1624. 10.1002/hep.23184PubMedCrossRef
5.
Metadata
Title
Stellate cells are mesenchymal stem cells
Authors
Claus Kordes
Iris Sawitza
Silke Götze
Diran Herebian
Dieter Häussinger
Publication date
01-12-2014
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue Special Issue 1/2014
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-19-S1-S6

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