Published in:
Open Access
01-12-2014 | Meeting abstract
Protein oxidative damage in the hippocampus in a mouse model of acute hyperammonemia
Authors:
Jasmin Klose, Boris Goerg, Carsten Berndt, Dieter Häussinger, Orhan Aktas, Tim Prozorovski
Published in:
European Journal of Medical Research
|
Special Issue 1/2014
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Excerpt
Hepatic encephalopathy (HE) is a common neuropsychiatric complication of both chronic and acute liver failure that is characterized by psychomotor, intellectual and cognitive impairment [
1]. The mechanism of neuronal dysfunction in HE has not yet been conclusively investigated and possibly implies numerous pathological processes. It is widely accepted that among the factors contributing to HE, hyperammonemia, due to ammonia dysmetabolism and inflammation as a response to infection, play a major role in the pathogenesis. A growing body of evidence, e.g. RNA oxidation and protein nitrosylation, further indicate that oxidative stress occurs in neural cells as a result of ammonia intoxication and may lead to subsequent tissue damage [
2,
3]. …
