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European Journal of Medical Research
Published in: European Journal of Medical Research 1/2014

Open Access 01-12-2014 | Meeting abstract

Enforced viral replication, a mechanism for immune activation

Authors: Karl S Lang, Nadine Honke, Namir Shaabani, Dieter Häussinger, Philipp A Lang

Published in: European Journal of Medical Research | Special Issue 1/2014

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Excerpt

Since many decades, it is known that viral infection can lead to a strong immune activation. This partially explains the strong association of viral infection with autoimmunity, immunopathology during chronic virus infections and complications during transplantation. One explanation for the strong immune stimulatory effects of viruses is the expression of specific patterns (e.g. viral RNA). Pathogen-specific patterns can be recognized by endogenous receptors (e.g.: Toll -like receptors), which are known to induce a strong innate immune activation. Whether further immunological mechanisms contribute to virus-specific immune activation is current topic of research. …
Literature
1.
Honke N, Shaabani N, Zhang DE, Iliakis G, Xu HC, Häussinger D, Recher M, Löhning M, Lang PA, Lang KS: Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes. PLoS Pathog 2013, 9: e1003650. 10.1371/journal.ppat.1003650PubMedCentralPubMedCrossRef
2.
Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS: Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol 2012, 13: 51–7.CrossRef
Metadata
Title
Enforced viral replication, a mechanism for immune activation
Authors
Karl S Lang
Nadine Honke
Namir Shaabani
Dieter Häussinger
Philipp A Lang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue Special Issue 1/2014
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/2047-783X-19-S1-S26

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