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Open Access 01-12-2014 | Research

Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats

Authors: Philipp Lingohr, Jonas Dohmen, Hanno Matthaei, Timo Schwandt, Gun-Soo Hong, Nils Konieczny, Edwin Bölke, Sven Wehner, Jörg C Kalff

Published in: European Journal of Medical Research | Issue 1/2014

Abstract

Background

Laparoscopic appendectomy (LA) has become one of the most common surgical procedures to date. To improve and standardize this technique further, cost-effective and reliable animal models are needed.

Methods

In a pilot study, 30 Wistar rats underwent laparoscopic caecum resection (as rats do not have an appendix vermiformis), to optimize the instrumental and surgical parameters. A subsequent test study was performed in another 30 rats to compare three different techniques for caecum resection and bowel closure.

Results

Bipolar coagulation led to an insufficiency of caecal stump closure in all operated rats (Group 1, n = 10). Endoloop ligation followed by bipolar coagulation and resection (Group 2, n = 10) or resection with a LigaSure™ device (Group 3, n = 10) resulted in sufficient caecal stump closure.

Conclusions

We developed a LA model enabling us to compare three different caecum resection techniques in rats. In conclusion, only endoloop closure followed by bipolar coagulation proved to be a secure and cost-effective surgical approach.

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Title: Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats
Authors: Philipp Lingohr
Jonas Dohmen
Hanno Matthaei
Timo Schwandt
Gun-Soo Hong
Nils Konieczny
Edwin Bölke
Sven Wehner
Jörg C Kalff
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2014
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-19-33

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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