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01-12-2011 | Case report

Combined treatment of uveal melanoma liver metastases

Authors: B Brasiuniene, V Sokolovas, V Brasiunas, A Barakauskiene, K Strupas

Published in: European Journal of Medical Research | Issue 2/2011

Abstract

Uveal melanoma (UM) is the most prevalent intraocular malignant tumor in the Western world. The prognosis of survival in the presence of metastatic disease is 2-7 months, depending on the treatment applied.

This article presents a case of metastatic UM with successful complex treatment of liver metastases.

A 49-year old female, underwent removal of the right eyeball in 1996 due to a histologically confirmed uveal melanoma. After 11 years, CT revealed a mass in the left kidney and multiple metastases in the liver. After left nephrectomy, 6 chemotherapy courses with dacarbazine were performed. The increasing liver metastases were observed. Additional 4 intraarterial (i/a) chemotherapy courses were administered using cisplatin, doxorubicin, fluorouracil, and interferon alfa. After few courses increase in CTC Grade 4 liver transaminases was seen. A partial response was observed, and in December 2008 the patient underwent surgery removing all liver metastases by 7 wedge or atypical resections. All margins were tumor-free. 21 months after liver resections and 14 years since diagnosis, the patient is alive without evidence of disease.

Successful treatment of metastatic uveal melanoma was due to a timely application of a combination of several treatment methods and good prognostic factors of the patient.

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Title: Combined treatment of uveal melanoma liver metastases
Authors: B Brasiuniene
V Sokolovas
V Brasiunas
A Barakauskiene
K Strupas
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 2/2011
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-16-2-71

At a glance: The STEP trials

Springer Medicine

Combined treatment of uveal melanoma liver metastases

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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