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Clinical Sarcoma Research
Published in: Clinical Sarcoma Research 1/2014

Open Access 01-12-2014 | Case Report

Neoadjuvant treatment of Dermatofibrosarcoma Protuberans of pancreas with Imatinib: case report and systematic review of literature

Authors: Mashaal Dhir, David G Crockett, Todd M Stevens, Peter T Silberstein, William J Hunter, Jason M Foster

Published in: Clinical Sarcoma Research | Issue 1/2014

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Abstract

Dermatofibrosarcoma Protuberans (DFSP) is a rare skin tumor, characterized by frequent local recurrence but is seldom metastatic. It is histologically characterized by storiform arrangement of spindle cells. Cytogenetically, most tumors are characterized by translocation 17:22 leading to overexpression of tyrosine kinase PDGFB which can be targeted with tyrosine kinase inhibitor, Imatinib. We describe the first case of unresectable pancreatic metastases from DFSP treated with neoadjuvant Imatinib and subsequently R0 metastectomy. Additionally, a comprehensive systematic review of DFSP pancreatic metastases and the current published data on the use of Imatinib in DFSP is summarized.
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Metadata
Title
Neoadjuvant treatment of Dermatofibrosarcoma Protuberans of pancreas with Imatinib: case report and systematic review of literature
Authors
Mashaal Dhir
David G Crockett
Todd M Stevens
Peter T Silberstein
William J Hunter
Jason M Foster
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Clinical Sarcoma Research / Issue 1/2014
Electronic ISSN: 2045-3329
DOI
https://doi.org/10.1186/2045-3329-4-8

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