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Molecular Autism
Published in: Molecular Autism 1/2015

Open Access 01-12-2015 | Review

Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females

Authors: Emily Ruzich, Carrie Allison, Paula Smith, Peter Watson, Bonnie Auyeung, Howard Ring, Simon Baron-Cohen

Published in: Molecular Autism | Issue 1/2015

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Abstract

The Autism-Spectrum Quotient (AQ) is a self-report measure of autistic traits. It is frequently cited in diverse fields and has been administered to adults of at least average intelligence with autism and to nonclinical controls, as well as to clinical control groups such as those with schizophrenia, prosopagnosia, anorexia, and depression. However, there has been no empirical systematic review of the AQ since its inception in 2001. The present study reports a comprehensive systematic review of the literature to estimate a reliable mean AQ score in individuals without a diagnosis of an autism spectrum condition (ASC), in order to establish a reference norm for future studies.
A systematic search of computerized databases was performed to identify studies that administered the AQ to nonclinical participant samples representing the adult male and female general population. Inclusion was based on a set of formalized criteria that evaluated the quality of the study, the usage of the AQ, and the population being assessed.
After selection, 73 articles, detailing 6,934 nonclinical participants, as well as 1,963 matched clinical cases of ASC (from available cohorts within each individual study), were analyzed. Mean AQ score for the nonclinical population was 16.94 (95% CI 11.6, 20.0), while mean AQ score for the clinical population with ASC was found to be 35.19 (95% CI 27.6, 41.1). In addition, in the nonclinical population, a sex difference in autistic traits was found, although no sex difference in AQ score was seen in the clinical ASC population.
These findings have implications for the study of autistic traits in the general population. Here, we confirm previous norms with more rigorous data and for the first time establish average AQ scores based on a systematic review, for populations of adult males and females with and without ASC. Finally, we advise future researchers to avoid risk of bias by carefully considering the recruitment strategy for both clinical and nonclinical groups and to demonstrate transparency by reporting recruitment methods for all participants.
Literature
1.
Wing L: The autistic continuum. In Aspects of autism: Biological Research. Edited by: Wing L. London: Gaskell/Royal College of Psychiatrists; 1988.
2.
Constantino J, Todd R: Autistic traits in the general population - A twin study. Arch Gen Psychiatry 2003, 60:524–30. 10.1001/archpsyc.60.5.524PubMed
3.
Posserud MB, Lundervold AJ, Gillberg C: Autistic features in a total population of 7–9-year-old children assessed by the ASSQ (Autism Spectrum Screening Questionnaire). J Child Psychol Psychiatry 2006, 47:167–75. 10.1111/j.1469-7610.2005.01462.xPubMed
4.
Baron-Cohen S: Empathizing, systemizing, and the extreme male brain theory of autism. In Sex differences in the human brain, their underpinnings and implications. Edited by: Savic I. Amsterdam, Netherlands: Elsevier science BV; 2010:167–75.
5.
Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E: The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 2001, 31:5–17. 10.1023/A:1005653411471PubMed
6.
Baron-Cohen S, Hoekstra RA, Knickmeyer R, Wheelwright S: The autism-spectrum quotient (AQ)–adolescent version. J Autism Dev Disord 2006, 36:343–50. 10.1007/s10803-006-0073-6PubMed
7.
Auyeung B, Baron-Cohen S, Wheelwright S, Allison C: The autism spectrum quotient: children’s version (AQ-Child). J Autism Dev Disord 2008, 38:1230–40. 10.1007/s10803-007-0504-zPubMed
8.
Allison C, Baron-Cohen S, Wheelwright S, Charman T, Richler J, Pasco G, Brayne C: The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative measure of autistic traits at 18–24 months of age: preliminary report. J Autism Dev Disord 2008, 38:1414–25. 10.1007/s10803-007-0509-7PubMed
9.
Constantino JN, Cruber CP: Social Responsiveness Scale, second edition (SRS-2). Los Angeles, CA: Western Psychological Services; 2012.
10.
Baird G, Simonoff E, Pickles A, Chandler S, Loucas T, Meldrum D, Charman T: Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet 2006, 368:210–5. 10.1016/S0140-6736(06)69041-7PubMed
11.
Austin EJ: Personality correlates of the broader autism phenotype as assessed by the Autism Spectrum Quotient (AQ). Pers Individ Dif 2005, 38:451–60. 10.1016/j.paid.2004.04.022
12.
Baron-Cohen S, Wheelwright S, Burtenshaw A, Hobson E: Mathematical talent is linked to autism. Hum Nature-an Interdiscip Biosoc Perspect 2007, 18:125–31.
13.
Roelfsema MT, Hoekstra RA, Allison C, Wheelwright S, Brayne C, Matthews FE, Baron-Cohen S: Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands. J Autism Dev Disord 2012, 42:734–9. 10.1007/s10803-011-1302-1PubMed
14.
Baron-Cohen S, Wheelwright S, Stott C, Bolton P, Goodyer I: Is there a link between engineering and autism? Autism 1997, 1:101–9. 10.1177/1362361397011010
15.
Woodbury-Smith MR, Robinson J, Wheelwright S, Baron-Cohen S: Screening adults for asperger syndrome using the AQ: a preliminary study of its diagnostic validity in clinical practice. J Autism Dev Disord 2005, 35:331–5. 10.1007/s10803-005-3300-7PubMed
16.
Hoekstra RA, Bartels M, Verweij CJH, Boomsma DI: Heritability of autistic traits in the general population. Arch Pediatr Adolesc Med 2007, 161:372–7. 10.1001/archpedi.161.4.372PubMed
17.
Wheelwright S, Auyeung B, Allison C, Baron-Cohen S: Defining the broader, medium and narrow autism phenotype among parents using the Autism Spectrum Quotient (AQ). Mol Autism 2010, 1:10. 10.1186/2040-2392-1-10PubMedCentralPubMed
18.
Bishop DVM, Maybery M, Maley A, Wong D, Hill W, Hallmayer J: Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: a study using the Autism-Spectrum Quotient. J Child Psychol Psychiatry 2004, 45:1431–6. 10.1111/j.1469-7610.2004.00325.xPubMed
19.
Baron-Cohen S: The extreme male brain theory of autism. Trends Cogn Sci 2002, 6:248–54. 10.1016/S1364-6613(02)01904-6PubMed
20.
Baron-Cohen S, Cassidy S, Auyeung B, Allison C, Achoukhi M, Robertson S, Pohl A, Lai M-C: Attenuation of typical sex differences in 800 adults with autism vs. 3,900 controls. PLoS One 2014, 9:e102251. 10.1371/journal.pone.0102251PubMedCentralPubMed
21.
R Core Team: R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2014.
22.
Bird G, Catmur C, Silani G, Frith C, Frith U: Attention does not modulate neural responses to social stimuli in autism spectrum disorders. Neuroimage 2006, 31:1614–24. 10.1016/j.neuroimage.2006.02.037PubMed
23.
Dziobek I, Fleck S, Kalbe E, Rogers K, Hassenstab J, Brand M, Kessler J, Woike JK, Wolf OT, Convit A: Introducing MASC: a movie for the assessment of social cognition. J Autism Dev Disord 2006, 36:623–36. 10.1007/s10803-006-0107-0PubMed
24.
Golan O, Baron-Cohen S, Hill JJ, Golan Y: The “Reading the Mind in Films” task: complex emotion recognition in adults with and without autism spectrum conditions. Soc Neurosci 2006, 1:111–23. 10.1080/17470910600980986PubMed
25.
White S, Hill E, Winston J, Frith U: An islet of social ability in Asperger Syndrome: judging social attributes from faces. Brain Cogn 2006, 61:69–77. 10.1016/j.bandc.2005.12.007PubMed
26.
Lombardo MV, Barnes JL, Wheelwright SJ, Baron-Cohen S: Self-referential cognition and empathy in austism. PLoS One 2007, 2:e883. 10.1371/journal.pone.0000883PubMedCentralPubMed
27.
Corden B, Chilvers R, Skuse D: Emotional modulation of perception in Asperger’s syndrome. J Autism Dev Disord 2008, 38:1072–80. 10.1007/s10803-007-0485-yPubMed
28.
Gowen E, Stanley J, Miall RC: Movement interference in autism-spectrum disorder. Neuropsychologia 2008, 46:1060–8. 10.1016/j.neuropsychologia.2007.11.004PubMed
29.
Crane L, Goddard L, Pring L: Sensory processing in adults with autism spectrum disorders. AUTISM 2009, 13:215–28. 10.1177/1362361309103794PubMed
30.
Crane L, Goddard L, Pring L: Specific and general autobiographical knowledge in adults with autism spectrum disorders: the role of personal goals. Memory 2009, 17:557–76. 10.1080/09658210902960211PubMed
31.
Towgood KJ, Meuwese JDI, Gilbert SJ, Turner MS, Burgess PW: Advantages of the multiple case series approach to the study of cognitive deficits in autism spectrum disorder. Neuropsychologia 2009, 47:2981–8. 10.1016/j.neuropsychologia.2009.06.028PubMedCentralPubMed
32.
Hall JK, Hutton SB, Morgan MJ: Sex differences in scanning faces: does attention to the eyes explain female superiority in facial expression recognition? Cogn Emot 2010, 24:629–37. 10.1080/02699930902906882
33.
Kuhn G, Benson V, Fletcher-Watson S, Kovshoff H, McCormick CA, Kirkby J, Leekam SR: Eye movements affirm: automatic overt gaze and arrow cueing for typical adults and adults with autism spectrum disorder. Exp Brain Res 2010, 201:155–65. 10.1007/s00221-009-2019-7PubMed
34.
Marsh AA, Kozak MN, Wegner DM, Reid ME, Yu HH, Blair RJR: The neural substrates of action identification. Soc Cogn Affect Neurosci 2010, 5:392–403. 10.1093/scan/nsq004PubMedCentralPubMed
35.
Philip RCM, Whalley HC, Stanfield AC, Sprengelmeyer R, Santos IM, Young AW, Atkinson AP, Calder AJ, Johnstone EC, Lawrie SM, Hall J: Deficits in facial, body movement and vocal emotional processing in autism spectrum disorders. Psychol Med 2010, 40:1919–29. 10.1017/S0033291709992364PubMed
36.
Harris CD, Lindell AK: The influence of autism-like traits on cheek biases for the expression and perception of happiness. Brain Cogn 2011, 77:11–6. 10.1016/j.bandc.2011.07.005PubMed
37.
Marsh LE, Hamilton AFDC: Dissociation of mirroring and mentalising systems in autism. Neuroimage 2011, 56:1511–9. 10.1016/j.neuroimage.2011.02.003PubMed
38.
Palermo R, Rivolta D, Wilson CE, Jeffery L: Adaptive face space coding in congenital prosopagnosia: typical figural aftereffects but abnormal identity aftereffects. Neuropsychologia 2011, 49:3801–12. 10.1016/j.neuropsychologia.2011.09.039PubMed
39.
Palermo R, Willis ML, Rivolta D, McKone E, Wilson CE, Calder AJ: Impaired holistic coding of facial expression and facial identity in congenital prosopagnosia. Neuropsychologia 2011, 49:1226–35. 10.1016/j.neuropsychologia.2011.02.021PubMedCentralPubMed
40.
Rojas DC, Teale PD, Maharajh K, Kronberg E, Youngpeter K, Wilson LB, Wallace A, Hepburn S: Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder. Mol Autism 2011, 2:11. 10.1186/2040-2392-2-11PubMedCentralPubMed
41.
Von dem Hagen EAH, Nummenmaa L, Yu R, Engell AD, Ewbank MP, Calder AJ: Autism spectrum traits in the typical population predict structure and function in the posterior superior temporal sulcus. Cereb Cortex 2011, 21:493–500. 10.1093/cercor/bhq062PubMedCentralPubMed
42.
White S, Coniston D, Rogers R, Frith U: Developing the Frith-Happé animations: a quick and objective test of theory of mind for adults with autism. Autism Res 2011, 4:149–54. 10.1002/aur.174PubMed
43.
Zwickel J, White SJ, Coniston D, Senju A, Frith U: Exploring the building blocks of social cognition: spontaneous agency perception and visual perspective taking in autism. Soc Cogn Affect Neurosci 2011, 6:564–71. 10.1093/scan/nsq088PubMedCentralPubMed
44.
Allison C, Auyeung B, Baron-Cohen S: Toward brief “Red Flags” for autism screening: the short Autism Spectrum Quotient and the Short Quantitative Checklist for Autism in toddlers in 1,000 cases and 3,000 controls [corrected]. J Am Acad Child Adolesc Psychiatry 2012, 51:202–212.e7. 10.1016/j.jaac.2011.11.003PubMed
45.
Bakhtiari R, Zürcher NR, Rogier O, Russo B, Hippolyte L, Granziera C, Araabi BN, Nili Ahmadabadi M, Hadjikhani N: Differences in white matter reflect atypical developmental trajectory in autism: a tract-based spatial statistics study. Neuroimage Clin 2012, 1:48–56. 10.1016/j.nicl.2012.09.001PubMedCentralPubMed
46.
Beacher FDCC, Radulescu E, Minati L, Baron-Cohen S, Lombardo MV, Lai M-C, Walker A, Howard D, Gray MA, Harrison NA, Critchley HD: Sex differences and autism: brain function during verbal fluency and mental rotation. PLoS One 2012, 7:e38355. 10.1371/journal.pone.0038355PubMedCentralPubMed
47.
Beacher FDCC, Minati L, Baron-Cohen S, Lombardo MV, Lai M-C, Gray MA, Harrison NA, Critchley HD: Autism attenuates sex differences in brain structure: a combined voxel-based morphometry and diffusion tensor imaging study. Am J Neuroradiol 2012, 33:83–9. 10.3174/ajnr.A2880PubMed
48.
Bejerot S, Eriksson JM, Bonde S, Carlström K, Humble MB, Eriksson E: The extreme male brain revisited: gender coherence in adults with autism spectrum disorder. Br J Psychiatry 2012, 201:116–23. 10.1192/bjp.bp.111.097899PubMed
49.
Benson V, Castelhano MS, Au-Yeung SK, Rayner K: Eye movements reveal no immediate “WOW” (“which one’s weird”) effect in autism spectrum disorder. Q J Exp Psychol 2012, 65:1139–50. 10.1080/17470218.2011.644305
50.
Crane L, Pring L, Jukes K, Goddard L: Patterns of autobiographical memory in adults with autism spectrum disorder. J Autism Dev Disord 2012, 42:2100–12. 10.1007/s10803-012-1459-2PubMed
51.
Damiano CR, Aloi J, Treadway M, Bodfish JW, Dichter GS: Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions. J Neurodev Disord 2012, 4:13. 10.1186/1866-1955-4-13PubMedCentralPubMed
52.
De Andres-Garcia S, Moya-Albiol L, Gonzalez-Bono E: Salivary cortisol and immunoglobulin A: responses to stress as predictors of health complaints reported by caregivers of offspring with autistic spectrum disorder. Horm Behav 2012, 62:464–74. 10.1016/j.yhbeh.2012.08.003PubMed
53.
Dohn A, Garza-Villarreal EA, Heaton P, Vuust P: Do musicians with perfect pitch have more autism traits than musicians without perfect pitch? An empirical study. PLoS One 2012, 7:e37961. 10.1371/journal.pone.0037961PubMedCentralPubMed
54.
Kessler K, Wang H: Spatial perspective taking is an embodied process, but not for everyone in the same way: differences predicted by sex and social skills score. Spat Cogn Comput 2012, 12:133–58.
55.
Lachat F, Hugueville L, Lemaréchal J-DJ-D, Conty L, George N: Oscillatory brain correlates of live joint attention: a dual-EEG study. Front Hum Neurosci 2012,6(JUNE 2012):156.PubMedCentralPubMed
56.
Maras KL, Bowler DM: Brief report: suggestibility, compliance and psychological traits in high-functioning adults with autism spectrum disorder. Res Autism Spectr Disord 2012, 6:1168–75. 10.1016/j.rasd.2012.03.013
57.
Norenzayan A, Gervais WM, Trzesniewski KH: Mentalizing deficits constrain belief in a personal god. PLoS One 2012, 7:e36880. 10.1371/journal.pone.0036880PubMedCentralPubMed
58.
Nummenmaa L, Engell AD, von dem Hagen E, Henson RNA, Calder AJ: Autism spectrum traits predict the neural response to eye gaze in typical individuals. Neuroimage 2012, 59:3356–63. 10.1016/j.neuroimage.2011.10.075PubMedCentralPubMed
59.
Webb SJ, Merkle K, Murias M, Richards T, Aylward E, Dawson G: ERP responses differentiate inverted but not upright face processing in adults with ASD. Soc Cogn Affect Neurosci 2012, 7:578–87. 10.1093/scan/nsp002PubMedCentralPubMed
60.
Berthoz S, Lalanne C, Crane L, Hill EL: Investigating emotional impairments in adults with autism spectrum disorders and the broader autism phenotype. Psychiatry Res 2013, 208:257–64. 10.1016/j.psychres.2013.05.014PubMed
61.
Broadbent J, Galic I, Stokes MA: Validation of autism spectrum quotient adult version in an Australian sample. Autism Res Treat 2013, 2013:984205.PubMedCentralPubMed
62.
Brown MS, Singel D, Hepburn S, Rojas DC: Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives. Autism Res 2013, 6:1–10. 10.1002/aur.1260PubMedCentralPubMed
63.
Cook R, Brewer R, Shah P, Bird G: Alexithymia, not autism, predicts poor recognition of emotional facial expressions. Psychol Sci 2013, 24:723–32. 10.1177/0956797612463582PubMed
64.
Crane L, Lind SESE, Bowler DMDM: Remembering the past and imagining the future in autism spectrum disorder. Memory 2013, 21:157–66. 10.1080/09658211.2012.712976PubMed
65.
Eriksson K: Autism-spectrum traits predict humor styles in the general population. Humor 2013, 26:461–75.
66.
Gibbard CR, Ren J, Seunarine KK, Clayden JD, Skuse DH, Clark CA: White matter microstructure correlates with autism trait severity in a combined clinical-control sample of high-functioning adults. Neuroimage Clin 2013, 3:106–14.PubMedCentralPubMed
67.
Haffey A, Press C, O’Connell G, Chakrabarti B: Autistic traits modulate mimicry of social but not nonsocial rewards. Autism Res 2013, 6:614–20. 10.1002/aur.1323PubMed
68.
Jackson BL, Blackwood EM, Blum J, Carruthers SP, Nemorin S, Pryor BA, Sceneay SD, Bevan S, Crewther DP: Magno - and parvocellular contrast responses in varying degrees of autistic trait. PLoS One 2013, 8:e66797. 10.1371/journal.pone.0066797PubMedCentralPubMed
69.
Kapp SK, Gillespie-Lynch K, Sherman LE, Hutman T: Deficit, difference, or both? Autism and neurodiversity. Dev Psychol 2013, 49:59–71.PubMed
70.
Lai M-C, Lombardo MV, Suckling J, Ruigrok ANV, Chakrabarti B, Ecker C, Deoni SCL, Craig MC, Murphy DGM, Bullmore ET, Consortium MA, Baron-Cohen S: Biological sex affects the neurobiology of autism. Brain 2013, 136:2799–815. 10.1093/brain/awt216PubMedCentralPubMed
71.
Lind SE, Williams DM, Raber J, Peel A, Bowler DM: Spatial navigation impairments among intellectually high-functioning adults with autism spectrum disorder: exploring relations with theory of mind, episodic memory, and episodic future thinking. J Abnorm Psychol 2013, 122:1189–99.PubMedCentralPubMed
72.
Miller LE, Saygin AP: Individual differences in the perception of biological motion: links to social cognition and motor imagery. Cognition 2013, 128:140–8. 10.1016/j.cognition.2013.03.013PubMed
73.
Moseley RL, Mohr B, Lombardo M, Baron-Cohen S, Hauk O, Pulvermuller F: Brain and behavioral correlates of action semantic deficits in autism. Front Hum Neurosci 2013, 7:725.PubMedCentralPubMed
74.
Nicolaidis C, Raymaker D, McDonald K, Dern S, Boisclair WC, Ashkenazy E, Baggs A: Comparison of healthcare experiences in autistic and non-autistic adults: a cross-sectional online survey facilitated by an academic-community partnership. J Gen Intern Med 2013, 28:761–9. 10.1007/s11606-012-2262-7PubMedCentralPubMed
75.
Wilson LB, Tregellas JR, Slason E, Pasko BE, Hepburn S, Rojas DC: Phonological processing in first-degree relatives of individuals with autism: An fMRI study. Hum Brain Mapp 2013, 34:1447–63. 10.1002/hbm.22001PubMedCentralPubMed
76.
Zürcher NR, Donnelly NN, Rogier OO, Russo BB, Hippolyte LL, Hadwin JJ, Lemonnier E, Hadjikhani NN: It’s all in the eyes: subcortical and cortical activation during grotesqueness perception in autism. PLoS One 2013, 8:e54313. 10.1371/journal.pone.0054313PubMedCentralPubMed
77.
Bennett RH, Bolling DZ, Anderson LC, Pelphrey KA, Kaiser MD: fNIRS detects temporal lobe response to affective touch. Soc Cogn Affect Neurosci 2014, 9:470–6. 10.1093/scan/nst008PubMedCentralPubMed
78.
Caldwell-Harris CL, Jordan CJ: Systemizing and special interests: characterizing the continuum from neurotypical to autism spectrum disorder. Learn Individ Differ 2014, 29:98–105.
79.
Damiano CR, Aloi J, Dunlap K, Burrus CJ, Mosner MG, Kozink RV, McLaurin RE, Mullette-Gillman OA, Carter RM, Huettel SA, McClernon FJ, Ashley-Koch A, Dichter GS: Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards. Mol Autism 2014, 5:7. 10.1186/2040-2392-5-7PubMedCentralPubMed
80.
Egorova N, Pulvermuİİer F, Shtyrov Y: Neural dynamics of speech act comprehension: an MEG study of naming and requesting. Brain Topogr 2014, 27:375–92. 10.1007/s10548-013-0329-3PubMedCentralPubMed
81.
Gökçen E, Petrides KV, Hudry K, Frederickson N, Smillie LD: Sub-threshold autism traits: the role of trait emotional intelligence and cognitive flexibility. Br J Psychol 2014, 105:187–99. 10.1111/bjop.12033PubMedCentralPubMed
82.
Hadjikhani N, Zürcher NR, Rogier O, Hippolyte L, Lemonnier E, Ruest T, Ward N, Lassalle A, Gillberg N, Billstedt E, Helles A, Gillberg C, Solomon P, Prkachin KM: Emotional contagion for pain is intact in autism spectrum disorders. Transl Psychiatry 2014, 4:e343. 10.1038/tp.2013.113PubMedCentralPubMed
83.
Kadak MT, Demirel OF, Yavuz M, Demir T: Recognition of emotional facial expressions and broad autism phenotype in parents of children diagnosed with autistic spectrum disorder. Compr Psychiatry 2014, 55:1146–51. 10.1016/j.comppsych.2014.03.004PubMed
84.
Lind SE, Williams DM, Bowler DM, Peel A: Episodic memory and episodic future thinking impairments in high-functioning autism spectrum disorder: An underlying difficulty with scene construction or self-projection? Neuropsychology 2014, 28:55–67.PubMedCentralPubMed
85.
Mayer JL, Heaton PF: Age and sensory processing abnormalities predict declines in encoding and recall of temporally manipulated speech in high-functioning adults with ASD. Autism Res 2014, 7:40–9. 10.1002/aur.1333PubMed
86.
Moseley RL, Pulvermüller F, Mohr B, Lombardo MV, Baron-Cohen S, Shtyrov Y: Brain routes for reading in adults with and without autism: EMEG evidence. J Autism Dev Disord 2014, 44:137–53. 10.1007/s10803-013-1858-zPubMedCentralPubMed
87.
Murray AL, Booth T, McKenzie K, Kuenssberg R, O’Donnell M: Are autistic traits measured equivalently in individuals with and without an autism spectrum disorder? An invariance analysis of the Autism Spectrum Quotient Short Form. J Autism Dev Disord 2014, 44:55–64. 10.1007/s10803-013-1851-6PubMed
88.
Rogers RD, Bayliss AP, Szepietowska A, Dale L, Reeder L, Pizzamiglio G, Czarna K, Wakeley J, Cowen PJ, Tipper SP: I want to help you, but I am not sure why: gaze-cuing induces altruistic giving. J Exp Psychol Gen 2014, 143:763–77.PubMedCentralPubMed
89.
Schwarzkopf DS, Anderson EJ, de Haas B, White SJ, Rees G: Larger extrastriate population receptive fields in autism spectrum disorders. J Neurosci 2014, 34:2713–24. 10.1523/JNEUROSCI.4416-13.2014PubMedCentralPubMed
90.
Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S: Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome. Mol Autism 2014, 5:4. 10.1186/2040-2392-5-4PubMedCentralPubMed
91.
Tottenham N, Hertzig ME, Gillespie-Lynch K, Gilhooly T, Millner AJ, Casey BJ: Elevated amygdala response to faces and gaze aversion in autism spectrum disorder. Soc Cogn Affect Neurosci 2014, 9:106–17. 10.1093/scan/nst050PubMedCentralPubMed
92.
Williams DM, Jarrold C, Grainger C, Lind SE: Diminished time-based, but undiminished event-based, prospective memory among intellectually high-functioning adults with autism spectrum disorder: relation to working memory ability. Neuropsychology 2014, 28:30–42.PubMedCentralPubMed
93.
Baron-Cohen S, Wheelwright S, Robinson J, Woodbury-Smith M: The Adult Asperger Assessment (AAA): a diagnostic method. J Autism Dev Disord 2005, 35:807–19. 10.1007/s10803-005-0026-5PubMed
94.
Brugha TS, McManus S, Smith J, Scott FJ, Meltzer H, Purdon S, Berney T, Tantam D, Robinson J, Radley J, Bankart J: Validating two survey methods for identifying cases of autism spectrum disorder among adults in the community. Psychol Med 2012, 42:647–56. 10.1017/S0033291711001292PubMed
95.
Ingersoll B, Hopwood CJ, Wainer A, Brent Donnellan M: A comparison of three self-report measures of the broader autism phenotype in a non-clinical sample. J Autism Dev Disord 2011, 41:1646–57. 10.1007/s10803-011-1192-2PubMed
96.
Nishiyama T, Suzuki M, Adachi K, Sumi S, Okada K, Kishino H, Sakai S, Kamio Y, Kojima M, Suzuki S, Kanne SM: Comprehensive comparison of self-administered questionnaires for measuring quantitative autistic traits in adults. J Autism Dev Disord 2013, 44:993–1007.
97.
Belmonte MK, Gomot M, Baron-Cohen S: Visual attention in autism families: ‘unaffected’ sibs share atypical frontal activation. J Child Psychol Psychiatry 2010, 51:259–76. 10.1111/j.1469-7610.2009.02153.xPubMed
98.
Ecker C, Suckling J, Deoni SC, Lombardo MV, Bullmore ET, Baron-Cohen S, Catani M, Jezzard P, Barnes A, Bailey AJ, Williams SC, Murphy DGM, Consortium MRCA: Brain anatomy and its relationship to behavior in adults with autism spectrum disorder. Arch Gen Psychiatry 2012, 69:195–209. 10.1001/archgenpsychiatry.2011.1251PubMed
99.
Auyeung B, Baron-Cohen S, Ashwin E, Knickmeyer R, Taylor K, Hackett G: Fetal testosterone and autistic traits. Br J Psychol 2009,100(Part 1):1–22.PubMed
100.
Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, Banerjee-Basu S, Baron-Cohen S: Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res 2009, 2:157–77. 10.1002/aur.80PubMed
101.
Wakabayashi A, Baron-Cohen S, Wheelwright S: Are autistic traits an independent personality dimension? A study of the Autism-Spectrum Quotient (AQ) and the NEO-PI-R. Pers Individ Dif 2006, 41:873–83. 10.1016/j.paid.2006.04.003
102.
Lau WY-P, Gau SS-F, Chiu Y-N, Wu Y-Y, Chou W-J, Liu S-K, Chou M-C: Psychometric properties of the Chinese version of the Autism Spectrum Quotient (AQ). Res Dev Disabil 2013, 34:294–305. 10.1016/j.ridd.2012.08.005PubMed
103.
Hoekstra RA, Bartels M, Cath DC, Boomsma DI: Factor structure, reliability and criterion validity of the Autism-Spectrum Quotient (AQ): a study in Dutch population and patient groups. J Autism Dev Disord 2008, 38:1555–66. 10.1007/s10803-008-0538-xPubMedCentralPubMed
104.
Sonié S, Kassai B, Pirat E, Masson S, Bain P, Robinson J, Reboul A, Wicker B, Chevallier C, Beaude-Chervet V, Deleage M-H, Charvet D, Barthelemy C, Rochet T, Tatou M, Arnaud V, Manificat S, Sonié S, Barthélémy C: French version of screening questionnaire for high-functioning autism or Asperger syndrome in adolescent: Autism Spectrum Quotient, Empathy Quotient and Systemizing Quotient. Protocol and questionnaire translation [Version française des questionnaires de. Press Medicale 2011, 40:e181–8. 10.1016/j.lpm.2010.07.016
105.
Ruta L, Mazzone D, Mazzone L, Wheelwright S, Baron-Cohen S: The Autism-Spectrum Quotient–Italian version: a cross-cultural confirmation of the broader autism phenotype. J Autism Dev Disord 2012, 42:625–33. 10.1007/s10803-011-1290-1PubMed
106.
Wakabayashi A, Tojo Y, Baron-Cohen S, Wheelwright S: [The Autism-Spectrum Quotient (AQ) Japanese version: evidence from high-functioning clinical group and normal adults]. Shinrigaku Kenkyu 2004, 75:78–84. 10.4992/jjpsy.75.78PubMed
107.
Mohammadi MR, Zarafshan H, Ghasempour S: Broader autism phenotype in Iranian parents of children with autism spectrum disorders vs. normal children. Iran J Psychiatry 2012, 7:157–63.PubMedCentralPubMed
108.
Pisula E, Kawa R, Szostakiewicz L, Lucka I, Kawa M, Rynkiewicz A: Autistic traits in male and female students and individuals with high functioning autism spectrum disorders measured by the Polish version of the Autism-Spectrum Quotient. PLoS One 2013, 8:e75236. 10.1371/journal.pone.0075236PubMedCentralPubMed
Metadata
Title
Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females
Authors
Emily Ruzich
Carrie Allison
Paula Smith
Peter Watson
Bonnie Auyeung
Howard Ring
Simon Baron-Cohen
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Molecular Autism / Issue 1/2015
Electronic ISSN: 2040-2392
DOI
https://doi.org/10.1186/2040-2392-6-2

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