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Published in: Diabetology & Metabolic Syndrome 1/2014

Open Access 01-12-2014 | Research

Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Authors: Ken Kishida, Yasuhiko Nakagawa, Hironori Kobayashi, Koji Yanagi, Tohru Funahashi, Iichiro Shimomura

Published in: Diabetology & Metabolic Syndrome | Issue 1/2014

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Abstract

Background

Adiponectin plays a role as a positive contributor to the stabilization of atherosclerotic plaques. Circulating total adiponectin (Total-APN) levels associates with the number of coronary vessels in men with coronary artery disease (CAD). We recently reported that adiponectin binds to C1q in human blood, and serum C1q-binding adiponectin (C1q-APN) /Total-APN levels are associated with CAD in type 2 diabetic subjects. The present study investigated the relationship between circulating C1q-APN levels and the number of angiographic coronary artery vessel in male subjects.

Methods

The study subjects were 53 male Japanese patients who underwent diagnostic coronary angiography. Blood total adiponectin (Total-APN), high-molecular weight adiponectin (HMW-APN), C1q-APN and C1q were measured by enzyme-linked immunosorbent assays.

Results

Serum C1q-APN/Total-APN ratio significantly increased in subjects with single and multi-vessel coronary diseases (p = 0.029 for trend, the Kruskal-Wallis test). However, serum Total-APN, HMW-APN, C1q-APN and C1q levels did not correlate with number of diseased coronary vessels.

Conclusion

Serum C1q-APN/Total-APN ratio progressively increases in men with single and multi-vessel coronary disease.

Trial registration

Appendix
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Metadata
Title
Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease
Authors
Ken Kishida
Yasuhiko Nakagawa
Hironori Kobayashi
Koji Yanagi
Tohru Funahashi
Iichiro Shimomura
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2014
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/1758-5996-6-64

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