Skip to main content
Top
Published in: Diabetology & Metabolic Syndrome 1/2011

Open Access 01-12-2011 | Research

Depression, glycemic control and type 2 diabetes

Authors: Marcelo Papelbaum, Rodrigo O Moreira, Walmir Coutinho, Rosane Kupfer, Leão Zagury, Silvia Freitas, José C Appolinário

Published in: Diabetology & Metabolic Syndrome | Issue 1/2011

Login to get access

Abstract

Background

Comorbid depression in diabetes has been suggested as one of the possible causes of an inadequate glycemic control. The purpose of this study was to investigate the association between major depression and the glycemic control of type 2 diabetes mellitus (T2DM).

Methods

Seventy T2DM patients were evaluated. They underwent a psychiatric examination using the following instruments: Structured Clinical Interview for DSM-IV and Beck Depression Inventory. The diabetes status was assessed in the short-term (glycemia, glycated hemoglobin) clinical control.

Results

The presence of current depression was observed in 18.6% (13/70). In addition, type 2 diabetes patients who displayed depression evidenced higher levels of glycated hemoglobin (8.6 ± 2.0 vs. 7.5 ± 1.8; p = 0.05) when compared to those who did not exhibit a mood disorder.

Conclusions

In our sample, the presence of depression seems to impact on the short-term control of T2DM. The authors discuss the clinical utility of these findings in the usual treatment of diabetes.
Appendix
Available only for authorised users
Literature
1.
go back to reference American Diabetes Association: Clinical Practice Recommendations. Diabetes Care. 2007, 1: S1-103. 10.1016/j.pcd.2006.10.001.CrossRef American Diabetes Association: Clinical Practice Recommendations. Diabetes Care. 2007, 1: S1-103. 10.1016/j.pcd.2006.10.001.CrossRef
2.
go back to reference Saydah SH, Fradkin J, Cowie CC: Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA. 2004, 291: 335-42. 10.1001/jama.291.3.335.CrossRefPubMed Saydah SH, Fradkin J, Cowie CC: Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA. 2004, 291: 335-42. 10.1001/jama.291.3.335.CrossRefPubMed
3.
go back to reference The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993, 329: 977-86.CrossRef The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993, 329: 977-86.CrossRef
4.
go back to reference Anderson RJ, Freedland KE, Clouse RE, Lustman PJ: The prevalence of comorbid depression in adults with diabetes. Diabetes Care. 2001, 24 (6): 1069-78. 10.2337/diacare.24.6.1069.CrossRefPubMed Anderson RJ, Freedland KE, Clouse RE, Lustman PJ: The prevalence of comorbid depression in adults with diabetes. Diabetes Care. 2001, 24 (6): 1069-78. 10.2337/diacare.24.6.1069.CrossRefPubMed
5.
go back to reference O'Connor PJ, Crain AL, Rush WA, Hanson AM, Fischer LR, Kluznik JC: Does diabetes double the risk of depression?. Ann Fam Med. 2009, 7 (4): 328-35. 10.1370/afm.964.PubMedCentralCrossRefPubMed O'Connor PJ, Crain AL, Rush WA, Hanson AM, Fischer LR, Kluznik JC: Does diabetes double the risk of depression?. Ann Fam Med. 2009, 7 (4): 328-35. 10.1370/afm.964.PubMedCentralCrossRefPubMed
6.
go back to reference Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE: Depression and poor glycemic control. Diabetes Care. 2000, 23 (7): 934-42. 10.2337/diacare.23.7.934.CrossRefPubMed Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE: Depression and poor glycemic control. Diabetes Care. 2000, 23 (7): 934-42. 10.2337/diacare.23.7.934.CrossRefPubMed
7.
go back to reference de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ: Association of depression and diabetes complications: A meta-analysis. Psychosom Med. 2001, 63: 619-30.CrossRefPubMed de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ: Association of depression and diabetes complications: A meta-analysis. Psychosom Med. 2001, 63: 619-30.CrossRefPubMed
8.
go back to reference American Diabetes Association: Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2010, 33: S629- American Diabetes Association: Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2010, 33: S629-
9.
go back to reference First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). 2002, New York: Biometrics Research, New York State Psychiatric Institute First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). 2002, New York: Biometrics Research, New York State Psychiatric Institute
10.
go back to reference Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry. 1961, 4: 561-71.CrossRefPubMed Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch Gen Psychiatry. 1961, 4: 561-71.CrossRefPubMed
11.
go back to reference Lustman PJ, Clouse RE, Griffith LS, Carney RM, Freedland KE: Screening for depression in diabetes using the Beck Depression Inventory. Psychosom Med. 1997, 59 (1): 24-31.CrossRefPubMed Lustman PJ, Clouse RE, Griffith LS, Carney RM, Freedland KE: Screening for depression in diabetes using the Beck Depression Inventory. Psychosom Med. 1997, 59 (1): 24-31.CrossRefPubMed
12.
go back to reference Hermanns N, Kulzer B, Krichbaum M, Kubiak T, Haak T: How to screen for depression and emotional problems in patients with diabetes: comparison of screening characteristics of depression questionnaires, measurement of diabetes-specific emotional problems and standard clinical assessment. Diabetologia. 2006, 469-477. 49 Hermanns N, Kulzer B, Krichbaum M, Kubiak T, Haak T: How to screen for depression and emotional problems in patients with diabetes: comparison of screening characteristics of depression questionnaires, measurement of diabetes-specific emotional problems and standard clinical assessment. Diabetologia. 2006, 469-477. 49
13.
go back to reference Gorenstein C, Andrade L: Validation of a Portuguese version of the Beck Depression Inventory and the State-Trait Anxiety Inventory in Brazilian subjects. Braz J Med Biol Res. 1996, 29 (4): 453-7.PubMed Gorenstein C, Andrade L: Validation of a Portuguese version of the Beck Depression Inventory and the State-Trait Anxiety Inventory in Brazilian subjects. Braz J Med Biol Res. 1996, 29 (4): 453-7.PubMed
14.
go back to reference Jalenques I, Tauveron I, Albuisson E, Lonjaret D, Thieblot P, Coudert AJ: Prevalence of anxiety and depressive symptoms in patients with type 1 and 2 diabetes. Rev Med Suisse Romande. 1993, 113: 639-46.PubMed Jalenques I, Tauveron I, Albuisson E, Lonjaret D, Thieblot P, Coudert AJ: Prevalence of anxiety and depressive symptoms in patients with type 1 and 2 diabetes. Rev Med Suisse Romande. 1993, 113: 639-46.PubMed
15.
go back to reference Lustman PJ, Griffith LS, Clouse RE, Cryer PE: Psychiatric illness in diabetes: relationship to symptoms and glucose control. J Nerv Ment Dis. 1986, 174: 736-742. 10.1097/00005053-198612000-00005.CrossRefPubMed Lustman PJ, Griffith LS, Clouse RE, Cryer PE: Psychiatric illness in diabetes: relationship to symptoms and glucose control. J Nerv Ment Dis. 1986, 174: 736-742. 10.1097/00005053-198612000-00005.CrossRefPubMed
16.
go back to reference Pouwer F, Beekman ATF, Nijpels G, et al: Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study. Diabetologia. 2003, 46: 892-8. 10.1007/s00125-003-1124-6.CrossRefPubMed Pouwer F, Beekman ATF, Nijpels G, et al: Rates and risks for co-morbid depression in patients with Type 2 diabetes mellitus: results from a community-based study. Diabetologia. 2003, 46: 892-8. 10.1007/s00125-003-1124-6.CrossRefPubMed
17.
go back to reference Kruse J, Schmitz N, Thefeld W: On the association between diabetes and mental disorders in a community sample: results from the German National Health Interview and Examination Survey. Diabetes Care. 2003, 26 (6): 1841-6. 10.2337/diacare.26.6.1841.CrossRefPubMed Kruse J, Schmitz N, Thefeld W: On the association between diabetes and mental disorders in a community sample: results from the German National Health Interview and Examination Survey. Diabetes Care. 2003, 26 (6): 1841-6. 10.2337/diacare.26.6.1841.CrossRefPubMed
18.
go back to reference Chew-Graham CA, Mullin S, Masy CR, Hedley S, Cole H: Managing depression in primary care: another example of the inverse care law?. Fam Pract. 2002, 19 (6): 632-7. 10.1093/fampra/19.6.632.CrossRefPubMed Chew-Graham CA, Mullin S, Masy CR, Hedley S, Cole H: Managing depression in primary care: another example of the inverse care law?. Fam Pract. 2002, 19 (6): 632-7. 10.1093/fampra/19.6.632.CrossRefPubMed
19.
go back to reference Thompson C, Kinmonth AL, Stevens L, Peveler RC, Stevens A, Ostler KJ, Pickering RM, Baker NG, Henson A, Preece J, Cooper D, Campbell MJ: Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial. Lancet. 2000, 355 (9199): 185-91. 10.1016/S0140-6736(99)03171-2.CrossRefPubMed Thompson C, Kinmonth AL, Stevens L, Peveler RC, Stevens A, Ostler KJ, Pickering RM, Baker NG, Henson A, Preece J, Cooper D, Campbell MJ: Effects of a clinical-practice guideline and practice-based education on detection and outcome of depression in primary care: Hampshire Depression Project randomised controlled trial. Lancet. 2000, 355 (9199): 185-91. 10.1016/S0140-6736(99)03171-2.CrossRefPubMed
20.
go back to reference Barley EA, Murray J, Walters P, Tylee A: Managing depression in primary care: A meta-synthesis of qualitative and quantitative research from the UK to identify barriers and facilitators. BMC Fam Pract. 2011, 12: 47-10.1186/1471-2296-12-47.PubMedCentralCrossRefPubMed Barley EA, Murray J, Walters P, Tylee A: Managing depression in primary care: A meta-synthesis of qualitative and quantitative research from the UK to identify barriers and facilitators. BMC Fam Pract. 2011, 12: 47-10.1186/1471-2296-12-47.PubMedCentralCrossRefPubMed
21.
go back to reference Skaff MM, Mullan JT, Almeida DM, Hoffman L, Masharani U, Fisher L: Daily negative mood affects fasting glucose in type 2 diabetes. Health Psychol. 2009, 28 (3): 265-72.PubMedCentralCrossRefPubMed Skaff MM, Mullan JT, Almeida DM, Hoffman L, Masharani U, Fisher L: Daily negative mood affects fasting glucose in type 2 diabetes. Health Psychol. 2009, 28 (3): 265-72.PubMedCentralCrossRefPubMed
22.
go back to reference Eren I, Erdi O, Ozcankaya R: Relationship between blood glucose control and psychiatric disorders in type II diabetic patients. Turk Psikiyatri Derg. 2003, 14 (3): 184-91.PubMed Eren I, Erdi O, Ozcankaya R: Relationship between blood glucose control and psychiatric disorders in type II diabetic patients. Turk Psikiyatri Derg. 2003, 14 (3): 184-91.PubMed
23.
go back to reference Richardson LK, Egede LE, Mueller M, Echols CL, Gebregziabher M: Longitudinal effects of depression on glycemic control in veterans with Type 2 diabetes. Gen Hosp Psychiatry. 2008, 30 (6): 509-14. 10.1016/j.genhosppsych.2008.07.001.CrossRefPubMed Richardson LK, Egede LE, Mueller M, Echols CL, Gebregziabher M: Longitudinal effects of depression on glycemic control in veterans with Type 2 diabetes. Gen Hosp Psychiatry. 2008, 30 (6): 509-14. 10.1016/j.genhosppsych.2008.07.001.CrossRefPubMed
24.
go back to reference de Groot M, Jacobson AM, Samson JA, Welch G: Glycemic control and major depression in patients with type 1 and type 2 diabetes mellitus. J Psychosom Res. 1999, 46 (5): 425-35. 10.1016/S0022-3999(99)00014-8.CrossRefPubMed de Groot M, Jacobson AM, Samson JA, Welch G: Glycemic control and major depression in patients with type 1 and type 2 diabetes mellitus. J Psychosom Res. 1999, 46 (5): 425-35. 10.1016/S0022-3999(99)00014-8.CrossRefPubMed
25.
go back to reference Aikens JE, Perkins DW, Piette JD, Lipton B: Association between depression and concurrent Type 2 diabetes outcomes varies by diabetes regimen. Diabet Med. 2008, 25 (11): 1324-9.PubMed Aikens JE, Perkins DW, Piette JD, Lipton B: Association between depression and concurrent Type 2 diabetes outcomes varies by diabetes regimen. Diabet Med. 2008, 25 (11): 1324-9.PubMed
Metadata
Title
Depression, glycemic control and type 2 diabetes
Authors
Marcelo Papelbaum
Rodrigo O Moreira
Walmir Coutinho
Rosane Kupfer
Leão Zagury
Silvia Freitas
José C Appolinário
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2011
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/1758-5996-3-26

Other articles of this Issue 1/2011

Diabetology & Metabolic Syndrome 1/2011 Go to the issue