Published in:
Open Access
01-12-2010 | Poster presentation
A magnifying glass onto renal function and serum lipid evolutions after tenofovir (TDF) and emtricitabine (FTC) in combination with atazanavir/ritonavir (ATV/r) versus efavirenz (EFV) as first-line HAART (the INCA trial)
Authors:
I Izzo, L Albini, A Calabresi, D Motta, R Bellagamba, R Fezza, P Narciso, L Sighinolfi, P Maggi, E Focà, M Mendeni, L Manili, M Magoni, G Carosi, E Quiros-Roldan, C Torti
Published in:
Journal of the International AIDS Society
|
Special Issue 4/2010
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Excerpt
Measures of glomerular filtration rate (GFR) showed discordant results. CKD-EPI creatinine formula resulted more accurate than other equations in subjects with normal or mildly decreased renal function in the general population and cystatin C could be even a more sensitive measure. As for lipids, lipoprotein subfractions were suggested to be more informative on the cardiovascular risk than the commonly used cholesterol subfractions, with protection conferred especially by HDLp-small (Baker et al. JID 2010). Prospective evaluation of all these markers upon initiation of standard HAART regimens is lacking. We conducted a small, intensive, randomized study in naïve HIV-infected patients comparing TDF/FTC+ATV/r versus TDF/FTC+EFV as first-line therapy for these novel markers. …
