Published in:
Open Access
01-12-2010 | Poster presentation
No effect of a single supratherapeutic dose of lersivirine, a next-generation NNRTI, on QTc interval in healthy subjects
Authors:
M Vourvahis, R Wong, NM Ndongo, M O'Gorman, M Tawadrous
Published in:
Journal of the International AIDS Society
|
Special Issue 4/2010
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Excerpt
Lersivirine (LRV) is a next-generation NNRTI currently under investigation in two Phase IIb studies at doses of 500 - 1000 mg QD. In vitro analyses suggest that LRV is a weak Ikr and CA2+ channel blocker. However, dose-ranging Phase I studies have not shown prolongation of QTc interval to date. This study was performed to investigate the effect of a supratherapeutic dose of LRV on QTc interval in healthy subjects, relative to matched placebo and active control. …