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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

Pharmacokinetic (PK) and pharmacodynamic analyses of once- and twice-daily darunavir/ritonavir (DRV/r) in the ODIN trial

Authors: V Sekar, G De La Rosa, T Van de Casteele, S Spinosa-Guzman, P Vis, RMW Hoetelmans

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

In the Phase III, randomised, open-label ODIN trial, treatment-experienced HIV-1-infected adults with no screening DRV resistance-associated mutations received DRV/r 800/100mg qd or DRV/r 600/100mg bid (both arms + ≥2 NRTIs). At Week 48, 72.1% qd vs 70.9% bid patients achieved HIV-1 RNA <50 copies/mL (95% CI = -6.1 to 8.5%, p<0.001; ITT-TLOVR), confirming non-inferiority of DRV/r qd. The relationship between DRV PK and efficacy and safety following treatment with DRV/r is explored. …
Metadata
Title
Pharmacokinetic (PK) and pharmacodynamic analyses of once- and twice-daily darunavir/ritonavir (DRV/r) in the ODIN trial
Authors
V Sekar
G De La Rosa
T Van de Casteele
S Spinosa-Guzman
P Vis
RMW Hoetelmans
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P185

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