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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

PK/PD modeling supports the dose-escalation decision in VIKING

Authors: M Lovern, M Underwood, G Nichols, I Song

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

In the VIKING study a 50 mg once daily regimen of the next generation HIV integrase inhibitor (INI) S/GSK1349572 (572) exhibited promising antiviral activity in an initial cohort (Cohort I) of treatment-experienced subjects with documented raltegravir (RAL) resistance. The purpose of this work was to evaluate via simulation techniques whether improved virologic responses could be achieved with higher doses in a second cohort (Cohort II) by utilizing pharmacokinetic (PK) and pharmacodynamic (PD) models derived using Cohort I data. …
Metadata
Title
PK/PD modeling supports the dose-escalation decision in VIKING
Authors
M Lovern
M Underwood
G Nichols
I Song
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P182

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