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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Poster presentation

High prevalence of the UGT1A1*28 variant in HIV-infected individuals in Greece

Authors: P Panagopoulos, D Paraskevis, V Sypsa, M Detsika, K Protopapas, V Sakka, G Poulakou, A Papadopoulos, G Petrikkos, A Hatzakis

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

Over the past few years there has been a remarkable increase in our knowledge of the variation in human genome. In parallel genotyping technologies have advanced significantly and allow sufficient throughput to accommodate genome-wide approaches. Hyperbilirubinemia is the most common adverse event in patients treated with atazanavir (ATV). Previous studies showed that polymorphisms in the uridine-glucuronosyl transferase (UGT1A1) enzyme and specifically the UGT1A1*28 variant may influence the risk of hyperbilirubinemia in patients treated with ATV/r. …
Metadata
Title
High prevalence of the UGT1A1*28 variant in HIV-infected individuals in Greece
Authors
P Panagopoulos
D Paraskevis
V Sypsa
M Detsika
K Protopapas
V Sakka
G Poulakou
A Papadopoulos
G Petrikkos
A Hatzakis
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-P146

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