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Journal of the International AIDS Society
Published in: Journal of the International AIDS Society 4/2010

Open Access 01-12-2010 | Oral presentation

0234. Mitochondrial ageing and antiretroviral therapy exposure

Authors: BAI Payne, CA Hateley, DC Samuels, IJ Wilson, M Santibanez-Koref, DA Price, PF Chinnery

Published in: Journal of the International AIDS Society | Special Issue 4/2010

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Excerpt

Normal human ageing is thought to be driven by the progressive accumulation of molecular defects, including somatic mitochondrial DNA (mtDNA) mutations. Certain nucleoside analogue anti-retroviral drugs (NRTIs) are known to cause reversible mtDNA depletion, but it is unknown whether they affect age-associated mtDNA mutation. …
Literature
1.
2.
Elson JL, Samuels DC, Turnbull DM, Chinnery PF: Am J Hum Gen. 2001, 68: 802-10.1086/318801.CrossRef
Metadata
Title
0234. Mitochondrial ageing and antiretroviral therapy exposure
Authors
BAI Payne
CA Hateley
DC Samuels
IJ Wilson
M Santibanez-Koref
DA Price
PF Chinnery
Publication date
01-12-2010
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1758-2652-13-S4-O28

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