Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2014

Open Access 01-12-2014 | Extended abstract

The future of traumatic brain injury research

Authors: Mark Wilson, Parjam Zolfaghari, Collete Griffin, David Lockey, Christos Tolias, Vishi Verma

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Special Issue 1/2014

Login to get access

Excerpt

Traumatic Brain Injury (TBI) research is evolving. The quest for level-1 evidence through randomised prospective interventional trials, while useful to establish safety and efficacy, is changing to an era of big data observational studies. Comparative Effectiveness Research (CER) utilises the observation of differences between treatments and centres without strict inclusion/exclusion criteria or formal intervention [1]. In addition, the transfer of monitoring technologies into the pre-hospital field will enable research into earlier, more critical phases of brain injury. These two changes in TBI research direction should enable a better understanding of the spectrum of TBI diseases and foster a future of precision, personalised TBI management. …
Literature
1.
Maas AIR, et al: Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. Journal of neurotrauma. 2012, 29 (1): 32-46.PubMedCentralCrossRefPubMed
2.
3.
Roozenbeek B, Maas AIR, Menon DK: Changing patterns in the epidemiology of traumatic brain injury. Nature reviews. Neurology. 2013, 9 (4): 231-236.CrossRefPubMed
4.
Fazel S, Wolf A, Pillas D, Lichtenstein P, Langstrom N: Suicide, Fatal Injuries, and Other Causes of Premature Mortality in Patients With Traumatic Brain Injury. JAMA Psychiatry. 2014, 71 (3): 326-333.PubMedCentralCrossRefPubMed
5.
Patel HC, et al: Trends in head injury outcome from 1989 to 2003 and the effect of neurosurgical care: an observational study. Lancet. 2005, 366 (9496): 1538-1544.CrossRefPubMed
6.
Kirkman MA, Jenks T, Bouamra O, Edwards A, Yates D, Wilson MH: Increased mortality associated with cerebral contusions following trauma in the elderly: bad patients or bad management?. Journal of Neurotrauma. 2013, 30 (16): 1385-1390.CrossRefPubMed
7.
Gregson BA, et al: Surgical trial in traumatic intracerebral hemorrhage (STITCH(Trauma)): study protocol for a randomized controlled trial. Trials. 2012, 13 (1): 193-193.PubMedCentralCrossRefPubMed
8.
9.
Edwards P, et al: Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. The Lancet. 2005, 365 (9475): 1957-1959.CrossRef
10.
Hurlbert RJ: Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. Journal of neurosurgery. 2000, 93 (1 Suppl): 1-7.PubMed
11.
Murray GD, et al: Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy. Journal of neurotrauma. 2005, 22 (5): 511-517.CrossRefPubMed
12.
Harrison DA, et al: Risk Adjustment In Neurocritical care (RAIN)--prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study. Health technology assessment (Winchester, England). 2013, 17 (23): vii-350.
13.
Chesnut RM, et al: A Trial of Intracranial-Pressure Monitoring in Traumatic Brain Injury. The New England journal of medicine. 2012, 367 (26): 2471-2481.PubMedCentralCrossRefPubMed
14.
Ebinger M: Prehospital thrombolysis: a manual from Berlin. Journal of Visualized Experiments. 2013, e50534-e50534. 10.3791/50534. 81
Metadata
Title
The future of traumatic brain injury research
Authors
Mark Wilson
Parjam Zolfaghari
Collete Griffin
David Lockey
Christos Tolias
Vishi Verma
Publication date
01-12-2014
Publisher
BioMed Central
DOI
https://doi.org/10.1186/1757-7241-22-S1-A7

Other articles of this Special Issue 1/2014

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 1/2014 Go to the issue

Poster presentation

The incidence of penetrating trauma in London: have previously reported increases persisted in the last six years?

Poster presentation

An observational study of intubation success rates and rescue airway techniques among 7256 pre-hospital physician intubations of trauma patients

Poster presentation

A training package for zone III Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)

Oral presentation

Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy

Poster presentation

The role of inflammation in secondary cardiac dysfunction following trauma

Poster presentation

Use of an unmanned aerial vehicle to support situation assessment and decision-making in search and rescue operations in the mountains