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Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Published in:

Open Access 01-12-2010 | Review

The contemporary role of blood products and components used in trauma resuscitation

Author: David J Dries

Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | Issue 1/2010

Abstract

Introduction

There is renewed interest in blood product use for resuscitation stimulated by recent military experience and growing recognition of the limitations of large-volume crystalloid resuscitation.

Methods

An editorial review of recent reports published by investigators from the United States and Europe is presented. There is little prospective data in this area.

Results

Despite increasing sophistication of trauma care systems, hemorrhage remains the major cause of early death after injury. In patients receiving massive transfusion, defined as 10 or more units of packed red blood cells in the first 24 hours after injury, administration of plasma and platelets in a ratio equivalent to packed red blood cells is becoming more common. There is a clear possibility of time dependent enrollment bias. The early use of multiple types of blood products is stimulated by the recognition of coagulopathy after reinjury which may occur as many as 25% of patients. These patients typically have large-volume tissue injury and are acidotic. Despite early enthusiasm, the value of administration of recombinant factor VIIa is now in question. Another dilemma is monitoring of appropriate component administration to control coagulopathy.

Conclusion

In patients requiring large volumes of blood products or displaying coagulopathy after injury, it appears that early and aggressive administration of blood component therapy may actually reduce the aggregate amount of blood required. If recombinant factor VIIa is given, it should be utilized in the fully resuscitated patient. Thrombelastography is seeing increased application for real-time assessment of coagulation changes after injury and directed replacement of components of the clotting mechanism.

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Kashuk JL, Moore EE, Sawyer M, Le T, Johnson J, Biffl WL, Cothren CC, Barnett C, Stahel P, Sillman CC, Sauaia A, Banerjee A: Postinjury coagulopathy management: Goal directed resuscitation via POC thrombelastography. Ann Surg. 2010, 251: 604-614. 10.1097/SLA.0b013e3181d3599c.PubMedCrossRef

Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, Pons PT: Epidemiology of trauma deaths: A reassessment. J Trauma. 1995, 38: 185-193. 10.1097/00005373-199502000-00006.PubMedCrossRef

Kashuk JL, Moore EE, Millikan JS, Moore JB: Major abdominal vascular trauma--a unified approach. J Trauma. 1982, 22: 672-679. 10.1097/00005373-198208000-00004.PubMedCrossRef

Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B: Predicting life-threatening coagulopathy in the massively transfused trauma patient: Hypothermia and acidoses revisited. J Trauma. 1997, 42: 857-862. 10.1097/00005373-199705000-00016.PubMedCrossRef

Simmons RL, Collins JA, Heisterkamp CA, Mills DE, Andren R, Phillips LL: Coagulation disorders in combat casualties. I. Acute changes after wounding. II. Effects of massive transfusion. III Post-resuscitative changes. Ann Surg. 1969, 169: 455-482. 10.1097/00000658-196904000-00001.PubMedCentralPubMedCrossRef

Counts RB, Haisch C, Simon T L, Maxwell NG, Heimbach DM, Carrico CJ: Hemostasis in massively transfused trauma patients. Ann Surg. 1979, 190: 91-99. 10.1097/00000658-197907000-00020.PubMedCentralPubMedCrossRef

Ledgerwood AM, Lucas CE: A review of studies on the effects of hemorrhagic shock and resuscitation on the coagulation profile. J Trauma. 2003, 54 (suppl): S68-S74.PubMed

Ciavarella D, Reed RL, Counts RB, Baron L, Pavlin E, Heimbach DM, Carrico CJ: Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patient. Br J Haematol. 1987, 67: 365-368. 10.1111/j.1365-2141.1987.tb02359.x.PubMedCrossRef

MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M: Early coagulopathy predicts mortality in trauma. J Trauma. 2003, 55: 39-44. 10.1097/01.TA.0000075338.21177.EF.PubMedCrossRef

10.

Moore EE, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, Duane TM, Weireter LJ, Gomez GA, Cipolle MD, Rodman GH, Malangoni MA, Hides GA, Omert LA, Gould SA, PolyHeme Study Group: Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: The USA multicenter trial. J Am Coll Surg. 2009, 208: 1-13. 10.1016/j.jamcollsurg.2008.09.023.PubMedCrossRef

11.

Hirshberg A, Dugas M, Banez EI, Scott BG, Wall MJ, Mattox KL: Minimizing dilutional coagulopathy in exsanguinating hemorrhage: A computer simulation. J Trauma. 2003, 54: 454-463. 10.1097/01.TA.0000053245.08642.1F.PubMedCrossRef

12.

Fresh-Frozen Plasma, Cryoprecipitate, and Platelets Administration Practice Guidelines Development Task Force of the College of American Pathologists: Practice parameters for the use of fresh-frozen plasma, cryoprecipitate and platelets. JAMA. 1994, 271: 777-781. 10.1001/jama.271.10.777.CrossRef

13.

Lundsgaard-Hansen P: Treatment of acute blood loss. Vox Sang. 1992, 63: 241-246. 10.1111/j.1423-0410.1992.tb01228.x.PubMedCrossRef

14.

Smetannikov Y, Hopkins D: Intraoperative bleeding: A mathematical model for minimizing hemoglobin loss. Transfusion. 1996, 36: 832-835. 10.1046/j.1537-2995.1996.36996420764.x.PubMedCrossRef

15.

Milles G, Koucky CJ, Zacheis HG: Experimental uncontrolled arterial hemorrhage. Surgery. 1966, 60: 434-442.PubMed

16.

Bickell WH, Bruttig SP, Wade CE: Hemodynamic response to abdominal aortotomy in the anesthetized swine. Circ Shock. 1989, 28: 321-332.PubMed

17.

Brohi K, Singh J, Heron M, Coats T: Acute traumatic coagulopathy. J Trauma. 2003, 54: 1127-1130. 10.1097/01.TA.0000069184.82147.06.PubMedCrossRef

18.

Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, Flaherty SF, Grathwohl KW, Spinella PC, Perkins JG, Beekley AC, McMullin NR, Park MS, Gonzalez EA, Wade CE, Dubick MA, Schwab CW, Moore FA, Champion HR, Hoyt DB, Hess JR: Damage control resuscitation: Directly addressing the early coagulopathy of trauma. J Trauma. 2007, 62: 307-310. 10.1097/TA.0b013e3180324124.PubMedCrossRef

19.

Hess JR, Brohi K, Dutton RP, Hauser CJ, Holcomb JB, Kluger Y, Mackway-Jones K, Parr MJ, Rizoli SB, Yukioka T, Hoyt DB, Bouillon B: The coagulopathy of trauma: A review of mechanisms. J Trauma. 2008, 65: 748-754. 10.1097/TA.0b013e3181877a9c.PubMedCrossRef

20.

MacLeod JB: Trauma and coagulopathy. A new paradigm to consider. Arch Surg. 2008, 143: 797-801. 10.1001/archsurg.143.8.797.PubMedCrossRef

21.

Martini WZ: Coagulopathy by hypothermia and acidosis: Mechanisms of thrombin generation and fibrinogen availability. J Trauma. 2009, 67: 202-209. 10.1097/TA.0b013e3181a602a7.PubMedCrossRef

22.

Duchesne JC, Islam TM, Stuke L, Timmer JR, Barbeau JM, Marr AB, Hunt JP, Dellavolpe JD, Wahl G, Greiffenstein P, Steeb GE, McGinness C, Baker CC, McSwain NE: Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy. J Trauma. 2009, 67: 33-39. 10.1097/TA.0b013e31819adb8e.PubMedCrossRef

23.

Schöchl H, Frietsch T, Pavelka M, Jámbor C: Hyperfibrinolysis after major trauma: Differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma. 2009, 67: 125-131.PubMedCrossRef

24.

Chesebro BB, Rahn P, Carles M, Esmon CT, Xu J, Brohi K, Frith D, Pittet JF, Cohen MJ: Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock. 2009, 32: 659-665. 10.1097/SHK.0b013e3181a5a632.PubMedCentralPubMedCrossRef

25.

Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF: Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein C pathway?. Ann Surg. 2007, 245: 812-818. 10.1097/01.sla.0000256862.79374.31.PubMedCentralPubMedCrossRef

26.

Niles SE, McLaughlin DF, Perkins JG, Wade CE, Li Y, Spinella PC, Holcomb JB: Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma. 2008, 64: 1459-1465. 10.1097/TA.0b013e318174e8bc.PubMedCrossRef

27.

Lau HK: The interaction between platelets and factor VII/VIIa. Transfus Apher Sci. 2003, 28: 279-283. 10.1016/S1473-0502(03)00047-8.PubMedCrossRef

28.

Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF: Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008, 64: 1211-1217. 10.1097/TA.0b013e318169cd3c.PubMedCrossRef

29.

Hulka F, Mullins RJ, Frank EH: Blunt brain injury activates the coagulation process. Arch Surg. 1996, 131: 923-928.PubMedCrossRef

30.

Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF: Early coagulopathy after traumatic brain injury: The role of hypoperfusion and the protein C pathway. J Trauma. 2007, 63: 1254-1262. 10.1097/TA.0b013e318156ee4c.PubMedCrossRef

31.

Reed RL, Bracey AW, Hudson JD, Miller TA, Fischer RP: Hypothermia and blood coagulation: Dissociation between enzyme activity and clotting factor levels. Circ Shock. 1990, 32: 141-152.PubMed

32.

Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF: Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?. Ann Surg. 2008, 247: 320-326. 10.1097/SLA.0b013e318162d616.PubMedCrossRef

33.

Landis RC: Protease activated receptors: Clinical relevance to hemostasis and inflammation. Hematol Oncol Clin North Am. 2007, 21: 103-113. 10.1016/j.hoc.2006.11.005.PubMedCrossRef

34.

Ganter MT, Brohi K, Cohen MJ, Shaffer LA, Walsh MC, Stahl GL, Pittet JF: Role of the alternative pathway in the early complement activation following major trauma. Shock. 2007, 28: 29-34. 10.1097/shk.0b013e3180342439.PubMedCrossRef

35.

Kauvar DS, Lefering R, Wade CE: Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006, 60: S3-S11. 10.1097/01.ta.0000199961.02677.19.PubMedCrossRef

36.

Acosta JA, Yang JC, Winchell RJ, Simons RK, Fortlage DA, Hollingsworth-Fridlund P, Hoyt DB: Lethal injuries and time to death in a level I trauma center. J Am Coll Surg. 1998, 186: 528-533. 10.1016/S1072-7515(98)00082-9.PubMedCrossRef

37.

Baker CC, Oppenheimer L, Stephens B, Lewis FR, Trunkey DD: Epidemiology of trauma deaths. Am J Surg. 1980, 140: 144-150. 10.1016/0002-9610(80)90431-6.PubMedCrossRef

38.

Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P: Impact of plasma transfusion in massively transfused trauma patients. J Trauma. 2009, 66: 693-697. 10.1097/TA.0b013e31817e5c77.PubMedCrossRef

39.

Kashuk JL, Moore EE, Johnson JL, Haenel J, Wilson M, Moore JB, Cothren CC, Biffl WL, Banerjee A, Sauaia A: Postinjury life threatening coagulopathy: Is 1:1 fresh frozen plasma:packed red blood cells the answer?. J Trauma. 2008, 65: 261-271. 10.1097/TA.0b013e31817de3e1.PubMedCrossRef

40.

Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA, St Jacques P, Young PP: Damage control hematology: The impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma. 2008, 64: 1177-1183. 10.1097/TA.0b013e31816c5c80.PubMedCrossRef

41.

Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS: Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008, 248: 447-458.PubMed

42.

Snyder CW, Weinberg JA, McGwin G Jr, Melton SM, George RL, Reiff DA, Cross JM, Hubbard-Brown J, Rue LW, Kerby JD: The relationship of blood product ratio to mortality: Survival benefit or survival bias?. J Trauma. 2009, 66: 358-364. 10.1097/TA.0b013e318196c3ac.PubMedCrossRef

43.

Riskin DJ, Tsai TC, Riskin L, Hernandez-Boussard T, Purtill M, Maggio PM, Spain DA, Brundage SI: Massive transfusion protocols: The role of aggressive resuscitation versus product ratio in mortality reduction. J Am Coll Surg. 2009, 209: 198-205. 10.1016/j.jamcollsurg.2009.04.016.PubMedCrossRef

44.

Sihler KC, Napolitano LM: Complications of massive transfusion. Chest. 2010, 137: 209-220. 10.1378/chest.09-0252.PubMedCrossRef

45.

Marik PE, Corwin HL: Acute lung injury following blood transfusion: Expanding the definition. Crit Care Med. 2008, 36: 3080-3084. 10.1097/CCM.0b013e31818c3801.PubMedCrossRef

46.

Gajic O, Rana R, Winters JL, Yilmaz M, Mendez JL, Rickman OB, O'Byrne MM, Evenson LK, Malinchoc M, DeGoey SR, Afessa B, Hubmayr RD, Moore SB: Transfusion-related acute lung injury in the critically ill: Prospective nested case-control study. Am R Respir Crit Care Med. 2007, 176: 886-891. 10.1164/rccm.200702-271OC.CrossRef

47.

Sihler KC, Napolitano LM: Massive transfusion: New insights. Chest. 2009, 136: 1654-1667. 10.1378/chest.09-0251.PubMedCrossRef

48.

Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB: The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008, 64: S79-S85. 10.1097/TA.0b013e318160a57b.PubMedCrossRef

49.

Napolitano L: Cumulative risks of early red blood cell transfusion. J Trauma. 2006, 60: S26-S34. 10.1097/01.ta.0000199979.95789.17.PubMedCrossRef

50.

Schulman CI, Nathe K, Brown M, Cohn SM: Impact of age of transfused blood in the trauma patient. J Trauma. 2002, 52: 1224-1225. 10.1097/00005373-200206000-00036.PubMedCrossRef

51.

Makley AT, Goodman MD, Friend LA, Deters JS, Johannigman JA, Dorlac WC, Lentsch AB, Pritts TA: Resuscitation with fresh whole blood ameliorates the inflammatory response after hemorrhagic shock. J Trauma. 2010, 68: 305-311. 10.1097/TA.0b013e3181cb4472.PubMedCentralPubMedCrossRef

52.

Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB: Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma. 2009, 66: S69-S76. 10.1097/TA.0b013e31819d85fb.PubMedCentralPubMedCrossRef

53.

Dutton RP, Lefering R, Lynn M: Database predictors of transfusion and mortality. J Trauma. 2006, 60: S70-S77. 10.1097/01.ta.0000200856.47545.64.PubMedCrossRef

54.

Inaba K, Teixeira PG, Shulman I, Nelson J, Lee J, Salim A, Brown C, Demetriades D, Rhee P: The impact of uncross-matched blood transfusion on the need for massive transfusion and mortality: Analysis of 5,166 uncross-matched units. J Trauma. 2008, 65: 1222-1226. 10.1097/TA.0b013e31818e8ff3.PubMedCrossRef

55.

Committee on Trauma, American College of Surgeons: Advanced Trauma Life Support (ATLS). 2008, Chicago, 55-84. 8

56.

Yücel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, Neugebauer EA, Wappler F, Bouillon B, Rixen D, Polytrauma Study Group of the German Trauma Society: Trauma Associated Severe Hemorrhage (TASH) Score: Probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma. 2006, 60: 1228-1237.PubMedCrossRef

57.

Nunez TC, Voskresensky IV, Dossett LA, Shinall R, Dutton WD, Cotton BA: Early prediction of massive transfusion in trauma: Simple as ABC (Assessment of Blood Consumption)?. J Trauma. 2009, 66: 346-352. 10.1097/TA.0b013e3181961c35.PubMedCrossRef

58.

Cotton BA, Dossett LA, Haut ER, Shafi S, Nunez TC, Au BK, Zaydfudim V, Johnston M, Arbogast P, Young PP: Multicetner validation of a simplified score to predict massive transfusion in trauma. J Trauma. 2010, 69 (suppl): S33-S39. 10.1097/TA.0b013e3181e42411.PubMedCrossRef

59.

Nunez TC, Dutton WD, May AK, Holcomb JB, Yound PP, Cotton BA: Emergency department blood transfusion predicts early massive transfusion and early blood component requirement. Transfusion. 2010, 50: 1914-1920. 10.1111/j.1537-2995.2010.02682.x.PubMedCrossRef

60.

Al-Ruzzeh S, Navia JL: The "off-label" role of recombinant factor VIIa in surgery: Is the problem deficient evidence or defective concept?. J Am Coll Surg. 2009, 209: 659-667. 10.1016/j.jamcollsurg.2009.07.018.PubMedCrossRef

61.

Veldman A, Hoffman M, Ehrenforth S: New insights into the coagulation system and implications for new therapeutic options with recombinant factor VIIa. Curr Med Chem. 2003, 10: 797-811. 10.2174/0929867033457728.PubMedCrossRef

62.

Viles-Gonzalez JF, Anand SX, Zafar MU, Fuster V, Badimon JJ: Tissue factor coagulation pathway: A new therapeutic target in atherothrombosis. J Cardiovasc Pharmacol. 2004, 43: 669-676. 10.1097/00005344-200405000-00009.PubMedCrossRef

63.

Levi M, Peters M, Büller HR: Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: A systematic review. Crit Care Med. 2005, 33: 883-890. 10.1097/01.CCM.0000159087.85970.38.PubMedCrossRef

64.

O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM: Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006, 295: 293-298.PubMedCrossRef

65.

Meng ZH, Wolberg AS, Monroe DM, Hoffman M: The effect of temperature and pH on the activity of factor VIIa: Implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma. 2003, 55: 886-891. 10.1097/01.TA.0000066184.20808.A5.PubMedCrossRef

66.

Nishijima DK, Zehtabchi S: Evidence-based Emergency Medicine/Critically Appraised Topic. The efficacy of recombinant activated factor VII in severe trauma. Ann Emerg Med. 2009, 54: 737-744. 10.1016/j.annemergmed.2009.01.027.PubMedCrossRef

67.

Boffard KD, Riou B, Warren B, Choong PI, Rizoli S, Rossaint R, Axelsen M, Kluger Y, for the NovoSeven Trauma Study Group: Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: Two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma. 2005, 59: 8-18. 10.1097/01.TA.0000171453.37949.B7.PubMedCrossRef

68.

Raobaikady R, Redman J, Ball JA, Maloney G, Grounds RM: Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: A double-blind, randomized, placebo-controlled trial. Br J Anaesth. 2005, 94: 586-591. 10.1093/bja/aei102.PubMedCrossRef

69.

Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B, CONTROL Study Group: Results of the CONTROL trial: Efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma. 2010, 69: 489-500. 10.1097/TA.0b013e3181edf36e.PubMedCrossRef

70.

Wade CE, Eastridge BJ, Jones JA, West SA, Spinella PC, Perkins JG, Dubick MA, Blackbourne LH, Holcomb JB: Use of recombinant factor VIIa in US military casualties for a five-year period. J Trauma. 2010, 69: 353-359. 10.1097/TA.0b013e3181e49059.PubMedCrossRef

71.

Dutton RP, McCunn M, Hyder M, D'Angelo M, O'Connor J, Hess JR, Scalea TM: Factor VIIa for correction of traumatic coagulopathy. J Trauma. 2004, 57: 709-719. 10.1097/01.TA.0000140646.66852.AB.PubMedCrossRef

72.

Stein DM, Dutton RP, Kramer ME, Scalea TM: Reversal of coagulopathy in critically ill patients with traumatic brain injury: Recombinant factor VIIa is more cost-effective than plasma. J Trauma. 2009, 66: 63-75. 10.1097/TA.0b013e318191bc8a.PubMedCrossRef

73.

Hsia CC, Chin-Yee IH, McAlister VC: Use of recombinant activated factor VII in patients without hemophilia: A meta-analysis of randomized control trials. Ann Surg. 2008, 248: 61-68. 10.1097/SLA.0b013e318176c4ec.PubMedCrossRef

74.

Hardy JF, Bélisle S, Van der Linden P: Efficacy and safety of recombinant activated factor VII to control bleeding in nonhemophiliac patients: A review of 17 randomized controlled trials. Ann Thorac Surg. 2008, 86: 1038-1048. 10.1016/j.athoracsur.2008.05.013.PubMedCrossRef

75.

Hess JR: Blood and coagulation support in trauma care. Hematology Am Soc Hematol Educ Program. 2007, 187-191.

76.

O'Shaughnessy DF, Atterbury C, Bolton Maggs P, Murphy M, Thomas D, Yates S, Williamson LM: British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol. 2004, 126: 11-28.PubMedCrossRef

77.

Dickneite G, Doerr B, Kaspereit F: Characterization of the coagulation deficit in porcine dilutional coagulopathy and substitution with a prothrombin complex concentrate. Anesth Analg. 2008, 106: 1070-1077. 10.1213/ane.0b013e318165dfbb.PubMedCrossRef

78.

Dickneite G, Pragst I: Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model. Br J Anaesth. 2009, 102: 345-354. 10.1093/bja/aen391.PubMedCentralPubMedCrossRef

79.

Dickneite G, Dörr B, Kaspereit F, Tanaka KA: Prothrombin complex concentrate versus recombinant factor VIIa for reversal of hemodilutional coagulopathy in a porcine trauma model. J Trauma. 2010, 68: 1151-1157. 10.1097/TA.0b013e3181b06364.PubMedCrossRef

80.

Lawson JM, Murphy MP: Challenges for providing effective hemostasis in surgery and trauma. Semin Hematol. 2004, 41: 55-64. 10.1053/j.seminhematol.2003.11.012.PubMedCrossRef

81.

Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B, Laupacis A, Fergusson D: Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2007, 4: CD001886-PubMed

82.

Ekbäck G, Axelsson K, Ryttberg L, Edlund B, Kjellberg J, Weckström J, Carlsson O, Schött U: Tranexamic acid reduces blood loss in total hip replacement surgery. Anesth Analg. 2000, 91: 1124-1130.PubMedCrossRef

83.

Okamoto S, Hijikata-Okunomiya A, Wanaka K, Okada Y, Okamoto U: Enzyme controlling medicines: Introduction. Semin Thromb Hemost. 1997, 23: 493-501. 10.1055/s-2007-996127.PubMedCrossRef

84.

CRASH-2 Trial Collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomized, placebo-controlled trial. Lancet. 2010, 376: 23-32. 10.1016/S0140-6736(10)60835-5.CrossRef

85.

Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, Allaouchiche B, Negrier C: Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. J Thromb Haemost. 2007, 5: 289-295. 10.1111/j.1538-7836.2007.02319.x.PubMedCrossRef

86.

Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL: Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma. 1997, 42: 716-722. 10.1097/00005373-199704000-00023.PubMedCrossRef

87.

Salooja N, Perry DJ: Thrombelastography. Blood Coagul Fibrinolysis. 2001, 12: 327-337. 10.1097/00001721-200107000-00001.PubMedCrossRef

88.

Jeger V, Zimmermann H, Exadaktylos AK: Can rapidTEG accelerate the search for coagulopathies in the patient with multiple injuries?. J Trauma. 2009, 66: 1253-1257. 10.1097/TA.0b013e31819d3caf.PubMedCrossRef

89.

Carroll RC, Craft RM, Langdon RJ, Clanton CR, Snider CC, Wellons DD, Dakin PA, Lawson CM, Enderson BL, Kurek SJ: Early evaluation of acute traumatic coagulopathy by thrombelastography. Transl Res. 2009, 154: 34-39. 10.1016/j.trsl.2009.04.001.PubMedCrossRef

90.

Park MS, Martini WZ, Dubick MA, Salinas J, Butenas S, Kheirabadi BS, Pusateri AE, Vos JA, Guymon CH, Wolf SE, Mann KG, Holcomb JB: Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma. 2009, 67: 266-276. 10.1097/TA.0b013e3181ae6f1c.PubMedCentralPubMedCrossRef

91.

Hartert H: Blutgerinnungstudien mit der Thromboelastographic, einen neven Untersuchungsverfahren. Klin Wochenschr. 1948, 26: 577-583. 10.1007/BF01697545.PubMedCrossRef

92.

Stahel PF, Moore EE, Schreier SL, Flierl MA, Kashuk JL: Transfusion strategies in postinjury coagulopathy. Curr Opin Anaesthesiol. 2009, 22: 289-298. 10.1097/ACO.0b013e32832678ed.PubMedCrossRef

93.

Martini WZ, Cortez DS, Dubick MA, Park MS, Holcomb JB: Thrombelastography is better than PT, aPTT and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs. J Trauma. 2008, 65: 535-543. 10.1097/TA.0b013e31818379a6.PubMedCrossRef

94.

Nielson VG: A comparison of the Thrombelastograph and the ROTEM. Blood Coagul Fibrinolysis. 2007, 18: 247-252. 10.1097/MBC.0b013e328092ee05.CrossRef

95.

Gaarder C, Naess PA, Frischknecht Christensen E, Hakala P, Handolin L, Heier HE, Ivancev K, Johansson P, Leppäniemi A, Lippert F, Lossius HM, Opdahl H, Pillgram-Larsen J, Røise O, Skaga NO, Søreide E, Stensballe J, Tonnessen E, Töttermann A, Ortenwall P, Ostlund A: Scandinavian Guidelines - "The massively bleeding patient". Scand J Surgery. 2008, 97: 15-36.

96.

Segal JB, Dzik WH, Transfusion Medicine/Hemostasis Clinical Trials Network: Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: An evidence-based review. Transfusion. 2005, 45: 1413-1425. 10.1111/j.1537-2995.2005.00546.x.PubMedCrossRef

97.

Rossaint R, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Gordini G, Stahel PF, Hunt BJ, Neugebauer E, Spahn DR: Key issues in advanced bleeding care in trauma. Shock. 2006, 26: 322-331. 10.1097/01.shk.0000225403.15722.e9.PubMedCrossRef

98.

Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernández-Mondejar E, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Stahel PF, Vincent JL, Spahn DR: Management of bleeding following major trauma: An updated European guideline. Crit Care. 2010, 14: R52-10.1186/cc8943.PubMedCentralPubMedCrossRef

99.

Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, David JS: Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. Br J Anaesth. 2008, 100: 792-797. 10.1093/bja/aen083.PubMedCrossRef

100.

Johansson PI, Stensballe J: Effect of haemostatic control resuscitation on mortality in massively bleeding patients: A before and after study. Vox Sang. 2009, 96: 111-118. 10.1111/j.1423-0410.2008.01130.x.PubMedCentralPubMedCrossRef

101.

Simmons JW, White CE, Eastridge BJ, Mace JE, Wade CE, Blackbourne LH: Impact of policy change on US Army combat transfusion practices. J Trauma. 2010, 69 (Suppl): S75-S80. 10.1097/TA.0b013e3181e44952.PubMedCrossRef

102.

Johansson PI, Stensballe J: Hemostatic resuscitation for massive bleeding: The paradigm of plasma and platelets-a review of the current literature. Transfusion. 2010, 50: 701-710. 10.1111/j.1537-2995.2009.02458.x.PubMedCrossRef

103.

Spahn DR, Cerny V, Coats TJ, Duranteau J, Fernández-Mondéjar E, Gordini G, Stahel PF, Hunt BJ, Komadina R, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R, Task Force for Advanced Bleeding Care in Trauma: Management of bleeding following major trauma: A European guideline. Crit Care. 2007, 11: R17-10.1186/cc5686.PubMedCentralPubMedCrossRef

Title: The contemporary role of blood products and components used in trauma resuscitation
Author: David J Dries
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine / Issue 1/2010
Electronic ISSN: 1757-7241
DOI: https://doi.org/10.1186/1757-7241-18-63

At a glance: The STEP trials

Springer Medicine

The contemporary role of blood products and components used in trauma resuscitation

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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