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Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2013

Open Access 01-12-2013 | Review

Regulation of microRNAs by epigenetics and their interplay involved in cancer

Authors: Xiaolan Liu, Xiaoyan Chen, Xinfang Yu, Yongguang Tao, Ann M Bode, Zigang Dong, Ya Cao

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2013

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Abstract

Similar to protein-coding genes, miRNAs are also susceptible to epigenetic modulation. Although numerous miRNAs have been shown to be affected by DNA methylation, the regulatory mechanism of histone modification on miRNA is not adequately understood. EZH2 and HDACs were recently identified as critical histone modifiers of deregulated miRNAs in cancer and can be recruited to a miRNA promoter by transcription factors such as MYC. Because miRNAs can modulate epigenetic architecture and can be regulated by epigenetic alteration, they could reasonably play an important role in mediating the crosstalk between epigenetic regulators. The complicated network between miRNAs and epigenetic machineries underlies the epigenetic–miRNA regulatory pathway, which is important in monitoring gene expression profiles. Regulation of miRNAs by inducing epigenetic changes reveals promising avenues for the design of innovative strategies in the fight against human cancer.
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Metadata
Title
Regulation of microRNAs by epigenetics and their interplay involved in cancer
Authors
Xiaolan Liu
Xiaoyan Chen
Xinfang Yu
Yongguang Tao
Ann M Bode
Zigang Dong
Ya Cao
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2013
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/1756-9966-32-96

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