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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2013

Open Access 01-12-2013 | Review

Long non-coding RNA: a new player in cancer

Authors: Hua Zhang, Zhenhua Chen, Xinxin Wang, Zunnan Huang, Zhiwei He, Yueqin Chen

Published in: Journal of Hematology & Oncology | Issue 1/2013

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Abstract

Emerging evidence showed that long non-coding RNAs (lncRNAs) play important roles in a wide range of biological processes and dysregulated lncRNAs are involved in many complex human diseases, including cancer. Although a few lncRNAs’ functions in cancer have been characterized, the detailed regulatory mechanisms of majority of lncRNAs in cancer initiation and progression remain largely unknown. In this review, we summarized recent progress on the mechanisms and functions of lncRNAs in cancer, especially focusing on the oncogenic and tumor suppressive roles of the newly identified lncRNAs, and the pathways these novel molecules might be involved in. Their potentials as biomarkers for diagnosis and prognosis in cancer are also discussed in this paper.
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Metadata
Title
Long non-coding RNA: a new player in cancer
Authors
Hua Zhang
Zhenhua Chen
Xinxin Wang
Zunnan Huang
Zhiwei He
Yueqin Chen
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2013
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-6-37

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