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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2012

Open Access 01-12-2012 | Review

Current management and novel agents for malignant melanoma

Authors: Byung Lee, Nikhil Mukhi, Delong Liu

Published in: Journal of Hematology & Oncology | Issue 1/2012

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Abstract

Advanced malignant melanoma remains a challenging cancer. Over the past year, there have been 3 agents approved for treatment of melanoma by Food and Drug Administration. These include pegylated interferon alpha-2b for stage III melanoma, vemurafenib for unresectable or metastatic melanoma with BRAF V600E mutation, and ipilimumab for treatment of unresectable or metastatic melanoma. This review will also update on the development of novel agents, including tyrosine kinase inhibitors and adoptive cellular therapy.
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Literature
1.
DeVita VT, Lawrence TS, Rosenberg SA: DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology. 2008, Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 8
2.
Eggermont AM: Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial. Lancet. 2008, 372 (9633): 117-26. 10.1016/S0140-6736(08)61033-8.CrossRefPubMed
3.
4.
5.
6.
Howlader N: Improved estimates of cancer-specific survival rates from population-based data. J Natl Cancer Inst. 2010, 102 (20): 1584-98. 10.1093/jnci/djq366.PubMedCentralCrossRefPubMed
7.
Bestak R, Halliday GM: Chronic low-dose UVA irradiation induces local suppression of contact hypersensitivity, Langerhans cell depletion and suppressor cell activation in C3H/HeJ mice. Photochem Photobiol. 1996, 64 (6): 969-74. 10.1111/j.1751-1097.1996.tb01863.x.CrossRefPubMed
8.
Haluska FG, Hodi FS: Molecular genetics of familial cutaneous melanoma. J Clin Oncol. 1998, 16 (2): 670-82.PubMed
9.
Kraemer KH: The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch Dermatol. 1994, 130 (8): 1018-21. 10.1001/archderm.1994.01690080084012.CrossRefPubMed
10.
Karakousis CP: Local recurrence in malignant melanoma: long-term results of the multiinstitutional randomized surgical trial. Ann Surg Oncol. 1996, 3 (5): 446-52. 10.1007/BF02305762.CrossRefPubMed
11.
Morton DL: Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006, 355 (13): 1307-17. 10.1056/NEJMoa060992.CrossRefPubMed
12.
Kirkwood JM: Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol. 1996, 14 (1): 7-17.PubMed
13.
Kirkwood JM: High- and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190. J Clin Oncol. 2000, 18 (12): 2444-58.PubMed
14.
Lens MB, Dawes M: Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma. Br J Dermatol. 2004, 150 (2): 179-85. 10.1111/j.1365-2133.2004.05708.x.CrossRefPubMed
15.
Serrone L: Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. J Exp Clin Cancer Res. 2000, 19 (1): 21-34.PubMed
16.
Middleton MR: Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol. 2000, 18 (1): 158-66.PubMed
17.
Avril MF: Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. J Clin Oncol. 2004, 22 (6): 1118-25. 10.1200/JCO.2004.04.165.CrossRefPubMed
18.
19.
Atkins MB: High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol. 1999, 17 (7): 2105-16.PubMed
20.
Attia P: Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol. 2005, 23 (25): 6043-53. 10.1200/JCO.2005.06.205.PubMedCentralCrossRefPubMed
21.
Melero I: Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer. 2007, 7 (2): 95-106. 10.1038/nrc2051.CrossRefPubMed
22.
Wolchok JD: Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010, 11 (2): 155-64. 10.1016/S1470-2045(09)70334-1.CrossRefPubMed
23.
Hersh EM: A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma. Invest New Drugs. 2011, 29 (3): 489-98. 10.1007/s10637-009-9376-8.CrossRefPubMed
24.
25.
Agarwala SS: Current systemic therapy for metastatic melanoma. Expert Rev Anticancer Ther. 2009, 9 (5): 587-95. 10.1586/era.09.25.CrossRefPubMed
26.
Robert C: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011, 364 (26): 2517-26. 10.1056/NEJMoa1104621.CrossRefPubMed
27.
Morgan RA: Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006, 314 (5796): 126-9. 10.1126/science.1129003.PubMedCentralCrossRefPubMed
28.
Robbins PF: Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol. 2011, 29 (7): 917-24. 10.1200/JCO.2010.32.2537.PubMedCentralCrossRefPubMed
29.
Davies H: Mutations of the BRAF gene in human cancer. Nature. 2002, 417 (6892): 949-54. 10.1038/nature00766.CrossRefPubMed
30.
Bloethner S: Malignant melanoma--a genetic overview. Actas Dermosifiliogr. 2009, 100 (Suppl 1): 38-51.CrossRefPubMed
31.
32.
Bollag G: Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010, 467 (7315): 596-9. 10.1038/nature09454.PubMedCentralCrossRefPubMed
33.
Guo J: Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol. 2011, 29 (21): 2904-9. 10.1200/JCO.2010.33.9275.CrossRefPubMed
34.
Moriwaki S: The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability. Mutat Res. 1996, 364 (2): 117-23.CrossRefPubMed
35.
Curtin JA: Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006, 24 (26): 4340-6. 10.1200/JCO.2006.06.2984.CrossRefPubMed
36.
Wei G, Rafiyath S, Liu D: First-line treatment for chronic myeloid leukemia: dasatinib, nilotinib, or imatinib. J Hematol Oncol. 2010, 3 (1): 47-10.1186/1756-8722-3-47.PubMedCentralCrossRefPubMed
37.
Wyman K: Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer. 2006, 106 (9): 2005-11. 10.1002/cncr.21834.CrossRefPubMed
38.
39.
40.
Fremin C, Meloche S: From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J Hematol Oncol. 2010, 3 (1): 8-10.1186/1756-8722-3-8.PubMedCentralCrossRefPubMed
41.
Metadata
Title
Current management and novel agents for malignant melanoma
Authors
Byung Lee
Nikhil Mukhi
Delong Liu
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2012
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-5-3

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