Top

Published in:

Open Access 01-12-2012 | Review

Allogeneic hematopoietic stem cell transplantation in China: where we are and where to go

Authors: Meng Lv, Xiao-Jun Huang

Published in: Journal of Hematology & Oncology | Issue 1/2012

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective and sometimes the only curative therapy for patients with certain hematological diseases. Allo-HSCT has been practiced in China for approximately 30 years, and great improvements have been made within the past decade, particularly in fields such as the haploidentical HSCT system, strategies to overcome relapse and GVHD, and modified HSCT for elderly patients. This review will describe the current situation and provide a prospective of these unique aspects of Allo-HSCT in China.

Available only for authorised users

Lu DP, Guo NL, Jin NR, Zheng H, Lu XJ, Shi Q, Shan FX, Jiang B, Tang H, Liu MY: Allogeneic bone marrow transplantation for the treatment of leukemia. Chin Med J (Engl). 1990, 103: 125-130.

Xu LP, Huang XJ: Current status and development of hematopoietic stem cell transplantation in China: a report from Chinese Hematopoietic Stem Cell Transplantation Register Group. Chin Med J (Engl). 2011, 124: 2548-2555.

Pasquini MCWZ: Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides, 2011. [http://www.cibmtr.org]

Jiang Q, Xu LP, Liu DH, Liu KY, Chen SS, Jiang B, Jiang H, Chen H, Chen YH, Han W et al: Imatinib mesylate versus allogeneic hematopoietic stem cell transplantation for patients with chronic myelogenous leukemia in the accelerated phase. Blood. 2011, 117: 3032-3040. 10.1182/blood-2010-09-308510.CrossRefPubMed

Huang XJ: Current status of haploidentical stem cell transplantation for leukemia. J Hematol Oncol. 2008, 1: 27-10.1186/1756-8722-1-27.PubMedCentralCrossRefPubMed

Fuchs EJ, Huang XJ, Miller JS: HLA-haploidentical stem cell transplantation for hematologic malignancies. Biol Blood Marrow Transplant. 2010, 16: S57-S63. 10.1016/j.bbmt.2009.10.032.PubMedCentralCrossRefPubMed

Reisner Y, Hagin D, Martelli MF: Haploidentical hematopoietic transplantation: current status and future perspectives. Blood. 2011, 118: 6006-6017. 10.1182/blood-2011-07-338822.CrossRefPubMed

Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S, Felicini R, Falcinelli F, Velardi A, Ruggeri L et al: Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol. 2005, 23: 3447-3454. 10.1200/JCO.2005.09.117.CrossRefPubMed

Brunstein CG, Fuchs EJ, Carter SL, Karanes C, Costa LJ, Wu J, Devine SM, Wingard JR, Aljitawi OS, Cutler CS et al: Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood. 2011, 118: 282-288. 10.1182/blood-2011-03-344853.PubMedCentralCrossRefPubMed

10.

Rizzieri DA, Koh LP, Long GD, Gasparetto C, Sullivan KM, Horwitz M, Chute J, Smith C, Gong JZ, Lagoo A et al: Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution. J Clin Oncol. 2007, 25: 690-697. 10.1200/JCO.2006.07.0953.CrossRefPubMed

11.

Davies JK, Gribben JG, Brennan LL, Yuk D, Nadler LM, Guinan EC: Outcome of alloanergized haploidentical bone marrow transplantation after ex vivo costimulatory blockade: results of 2 phase 1 studies. Blood. 2008, 112: 2232-2241. 10.1182/blood-2008-03-143636.PubMedCentralCrossRefPubMed

12.

Federmann B, Bornhauser M, Kordelas L, Beelen DW, Stuhler G, Schwerdtfeger R, Stelljes M, Behre G, Christopeit M, Faul C et al: Results of a Phase II Study of Haploidentical Hematopoietic Cell Transplantation (HHCT) in Adults Using Reduced Intensity Conditioning and CD3/CD19-Depleted Grafts: clinical outcome and immune reconstitution. ASH Annual Meeting Abstracts. 2009, 114: 1203-

13.

Kurokawa T, Ishiyama K, Ozaki J, Yamashita Y, Iwaki N, Saito C, Arahata M, Kaya H, Yoshida T: Haploidentical hematopoietic stem cell transplantation to adults with hematologic malignancies: analysis of 66 cases at a single Japanese center. Int J Hematol. 2010, 91: 661-669. 10.1007/s12185-010-0561-5.CrossRefPubMed

14.

Huang XJ: Long Term Follow-up of Haploidentical Hematopoietic Stem Cell Transplantation without in Vitro T Cell Depletion for the Treatment of Hematological Malignancies: 9-Year Experience of a Single Center. ASH Annual Meeting Abstracts. 2011, 118: 839-

15.

Lee KH, Lee JH, Kim DY, Seol M, Lee YS, Kang YA, Jeon M, Hwang HJ, Jung AR, Kim SH et al: Reduced-intensity conditioning therapy with busulfan, fludarabine, and antithymocyte globulin for HLA-haploidentical hematopoietic cell transplantation in acute leukemia and myelodysplastic syndrome. Blood. 2011, 118: 2609-2617. 10.1182/blood-2011-02-339838.CrossRefPubMed

16.

Huang W, Li H, Gao C, Bo J, Wang Q, Zhao Y, Jing Y, Wang S, Zhu H, Dou L et al: Unmanipulated HLA-mismatched/haploidentical peripheral blood stem cell transplantation for high-risk hematologic malignancies. Transfusion. 2012, doi: 10.1111/j.1537-2995.2011.03478.x

17.

Hong JL: A brief introduction of the Chinese Marrow Donor Program. Hong Kong Med J. 2009, 15: 45-47.PubMed

18.

Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W, Chen YH, Wang JZ, Gao ZY, Zhang YC et al: Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant. 2006, 38: 291-297. 10.1038/sj.bmt.1705445.CrossRefPubMed

19.

Lu DP, Dong L, Wu T, Huang XJ, Zhang MJ, Han W, Chen H, Liu DH, Gao ZY, Chen YH et al: Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation. Blood. 2006, 107: 3065-3073. 10.1182/blood-2005-05-2146.CrossRefPubMed

20.

Xiao-Jun H, Lan-Ping X, Kai-Yan L, Dai-Hong L, Huan C, Wei H, Yu-Hong C, Jing-Zhi W, Yao C, Xiao-Hui Z et al: HLA-mismatched/haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for chronic myeloid leukemia: improved outcomes in patients in accelerated phase and blast crisis phase. Ann Med. 2008, 40: 444-455. 10.1080/07853890801908903.CrossRefPubMed

21.

Xiao-Jun H, Lan-Ping X, Kai-Yan L, Dai-Hong L, Yu W, Huan C, Yu-Hong C, Wei H, Jing-Zhi W, Yao C et al: Partially matched related donor transplantation can achieve outcomes comparable with unrelated donor transplantation for patients with hematologic malignancies. clin cancer res. 2009, 15: 4777-4783. 10.1158/1078-0432.CCR-09-0691.CrossRefPubMed

22.

Wang Y, Liu DH, Xu LP, Liu KY, Chen H, Chen YH, Han W, Shi HX, Huang XJ: Superior graft-versus-leukemia effect associated with transplantation of haploidentical compared with HLA-identical sibling donor grafts for high-risk acute leukemia: an historic comparison. Biol Blood Marrow Transplant. 2011, 17: 821-830. 10.1016/j.bbmt.2010.08.023.CrossRefPubMed

23.

Guo M, Sun Z, Sun QY, Han Q, Yu CL, Wang DH, Qiao JH, Chen B, Sun WJ, Hu KX et al: A modified haploidentical nonmyeloablative transplantation without T cell depletion for high-risk acute leukemia: successful engraftment and mild GVHD. Biol Blood Marrow Transplant. 2009, 15: 930-937. 10.1016/j.bbmt.2009.04.006.CrossRefPubMed

24.

Han W, Huang XJ, Liu KY, Xu LP, Liu DH, Chen H, Zhang XH, Chen YH, Wang FR, Wang Y: The efficacy and safety of mismatched hematopoietic stem cell transplantation for treatment of severe aplastic anemia. Zhonghua Nei Ke Za Zhi. 2011, 50: 287-290.PubMed

25.

Lee KW, Oh DH, Lee C, Yang SY: Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. Tissue Antigens. 2005, 65: 437-447. 10.1111/j.1399-0039.2005.00386.x.CrossRefPubMed

26.

Okamoto S: Current status of Japan marrow donor program (JMDP) and its roles in international cooperation. Int J Hematol. 2002, 76 (Suppl 1): 310-311.CrossRefPubMed

27.

Trachtenberg E, Vinson M, Hayes E, Hsu YM, Houtchens K, Erlich H, Klitz W, Hsia Y, Hollenbach J: HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China. Tissue Antigens. 2007, 70: 455-463. 10.1111/j.1399-0039.2007.00932.x.CrossRefPubMed

28.

Wu GG, Deng ZH, Gao SQ, Cheng LH, Jin SZ, Zhou D, Li Z, Zou HY, Zhang X, Wei TL et al: Study of HLA polymorphism in the 6965 Han bone marrow registry donors. Zhonghua Xue Ye Xue Za Zhi. 2004, 25: 473-477.PubMed

29.

Buhler S, Sanchez-Mazas A: HLA DNA sequence variation among human populations: molecular signatures of demographic and selective events. PLoS One. 2011, 6: e14643-10.1371/journal.pone.0014643.PubMedCentralCrossRefPubMed

30.

Jun HX, Jun CY, Yu ZX: In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow grafts using granulocyte colony-stimulating factor. Haematologica. 2004, 89: 1517-1524.PubMed

31.

Jun HX, Jun CY, Yu ZX: A direct comparison of immunological characteristics of granulocyte colony-stimulating factor (G-CSF)-primed bone marrow grafts and G-CSF-mobilized peripheral blood grafts. Haematologica. 2005, 90: 715-716.PubMed

32.

Huang XJ, Chang YJ, Zhao XY: Maintaining hyporesponsiveness and polarization potential of T cells after in vitro mixture of G-CSF mobilized peripheral blood grafts and G-CSF primed bone marrow grafts in different proportions. Transpl Immunol. 2007, 17: 193-197. 10.1016/j.trim.2006.10.002.CrossRefPubMed

33.

Feng X, Kajigaya S, Solomou EE, Keyvanfar K, Xu X, Raghavachari N, Munson PJ, Herndon TM, Chen J, Young NS: Rabbit ATG but not horse ATG promotes expansion of functional CD4 + CD25highFOXP3+ regulatory T cells in vitro. Blood. 2008, 111: 3675-3683. 10.1182/blood-2008-01-130146.PubMedCentralCrossRefPubMed

34.

Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F : Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002, 295: 2097-2100. 10.1126/science.1068440.CrossRefPubMed

35.

Huang XJ, Zhao XY, Liu DH, Liu KY, Xu LP: Deleterious effects of KIR ligand incompatibility on clinical outcomes in haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion. Leukemia. 2007, 21: 848-851.PubMed

36.

Chang YJ, Zhao XY, Huang XJ: Effects of the NK cell recovery on outcomes of unmanipulated haploidentical blood and marrow transplantation for patients with hematologic malignancies. Biol Blood Marrow Transplant. 2008, 14: 323-334. 10.1016/j.bbmt.2007.12.497.CrossRefPubMed

37.

Xiao H, Shi J, Luo Y, Tan Y, He J, Xie W, Zhang L, Wang Y, Liu L, Wu K et al: First report of multiple CEBPA mutations contributing to donor origin of leukemia relapse after allogeneic hematopoietic stem cell transplantation. Blood. 2011, 117: 5257-5260. 10.1182/blood-2010-12-326322.CrossRefPubMed

38.

Diamond HR, Ornellas MH, Orfao A, Gomes BE, Campos MM, Fernandez TS, da Silva RI, Alves G, Lage C, da Silva DA et al: Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms. J Hematol Oncol. 2011, 4: 39-10.1186/1756-8722-4-39.PubMedCentralCrossRefPubMed

39.

Huang XJ: Immunomodulatory strategies for relapse after haploidentical hematopoietic stem cell transplantation in hematologic malignancy patients. Best Pract Res Clin Haematol. 2011, 24: 351-358. 10.1016/j.beha.2011.04.002.CrossRefPubMed

40.

Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D et al: Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood. 1995, 86: 2041-2050.PubMed

41.

Huang XJ, Wang Y, Liu DH, Xu LP, Liu KY, Chen H, Chen YH, Han W, Shi HX: Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect. Bone Marrow Transplant. 2009, 44: 309-316. 10.1038/bmt.2009.26.CrossRefPubMed

42.

Huang X, Guo N, Ren H, Zhang Y, Gao Z, Lu D: An improved anti-leukemic effect achieved with donor progenitor cell infusion for relapse patients after allogeneic bone marrow transplantation. Chin Med J (Engl). 2003, 116: 736-741.

43.

Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W: Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation. Haematologica. 2007, 92: 414-417. 10.3324/haematol.10570.CrossRefPubMed

44.

Huang XJ, Liu DH, Xu LP, Chen H, Han W, Liu KY, Lu DP: Prophylactic infusion of donor granulocyte colony stimulating factor mobilized peripheral blood progenitor cells after allogeneic hematological stem cell transplantation in patients with high-risk leukemia. Leukemia. 2006, 20: 365-368. 10.1038/sj.leu.2403995.CrossRefPubMed

45.

Huang XJ, Liu DH, Liu KY, Xu LP, Chen YH, Wang Y, Han W, Chen H: Modified donor lymphocyte infusion after HLA-mismatched/haploidentical T cell-replete hematopoietic stem cell transplantation for prophylaxis of relapse of leukemia in patients with advanced leukemia. J Clin Immunol. 2008, 28: 276-283. 10.1007/s10875-007-9166-z.CrossRefPubMed

46.

Yan CH, Liu DH, Liu KY, Xu LP, Liu YR, Chen H, Han W, Wang Y, Qin YZ, Huang XJ: Risk stratification-directed donor lymphocyte infusion could reduce relapse of standard-risk acute leukemia patients after allogeneic hematopoietic stem cell transplantation. Blood. 2012, doi:10.1182/blood-2011-09-380386

47.

Huang XJ, Wang Y, Liu DH, Xu LP, Chen H, Chen YH, Han W, Shi HX, Liu KY: Modified donor lymphocyte infusion (DLI) for the prophylaxis of leukemia relapse after hematopoietic stem cell transplantation in patients with advanced leukemia-feasibility and safety study. J Clin Immunol. 2008, 28: 390-397. 10.1007/s10875-008-9193-4.CrossRefPubMed

48.

Yang Y, Wang H, Yu H, Yeap BY, Liang T, Wang G, Cheng T, Yang YG: IFN-gamma promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation. Blood. 2011, 118: 3721-3724. 10.1182/blood-2010-05-283887.PubMedCentralCrossRefPubMed

49.

Wang Y, Xu LP, Liu KY, Liu DH, Wang J, Chen H, Chen YH, Han W, Huang XJ: Low-dose MTX combined with low-dose methylprednisolone as a first-line therapy for the treatment of acute GVHD: safety and feasibility. Bone Marrow Transplant. 2011, 46: 892-898. 10.1038/bmt.2010.197.CrossRefPubMed

50.

Wang Y, Xu LP, Liu DH, Chen H, Chen YH, Han W, Liu KY, Huang XJ: First-line therapy for chronic graft-versus-host disease that includes low-dose methotrexate is associated with a high response rate. Biol Blood Marrow Transplant. 2009, 15: 505-511. 10.1016/j.bbmt.2008.12.493.CrossRefPubMed

51.

Wolff D, Schleuning M, von Harsdorf S, Bacher U, Gerbitz A, Stadler M, Ayuk F, Kiani A, Schwerdtfeger R, Vogelsang GB et al: Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2011, 17: 1-17. 10.1016/j.bbmt.2010.05.011.CrossRefPubMed

52.

Lai Y, Ma J, Schwarzenberger P, Li W, Cai Z, Zhou J, Peng Z, Yang J, Luo L, Luo J et al: Combination of CsA, MTX and low-dose, short-course mycophenolate mofetil for GVHD prophylaxis. Bone Marrow Transplant. 2009, 43: 61-67. 10.1038/bmt.2008.265.CrossRefPubMed

53.

Fang J, Hu C, Hong M, Wu Q, You Y, Zhong Z, Li W, Zou P, Hu Y, Xia L: Prophylactic Effects of Interleukin-2 Receptor Antagonists against Graft-versus-Host Disease following Unrelated Donor Peripheral Blood Stem Cell Transplantation. Biol Blood Marrow Transplant. 2011, doi:10.1016/j.bbmt.2011.09.005

54.

Ning H, Yang F, Jiang M, Hu L, Feng K, Zhang J, Yu Z, Li B, Xu C, Li Y et al: The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia. 2008, 22: 593-599. 10.1038/sj.leu.2405090.CrossRefPubMed

55.

Weng JY, Du X, Geng SX, Peng YW, Wang Z, Lu ZS, Wu SJ, Luo CW, Guo R, Ling W et al: Mesenchymal stem cell as salvage treatment for refractory chronic GVHD. Bone Marrow Transplant. 2010, 45: 1732-1740. 10.1038/bmt.2010.195.PubMedCentralCrossRefPubMed

56.

Zhao F, Zhang Y, Wang H, Jin M, He S, Shi Y, Guo Y: Blockade of osteopontin reduces alloreactive CD8+ T cell-mediated graft-versus-host disease. Blood. 2011, 117: 1723-1733. 10.1182/blood-2010-04-281659.PubMedCentralCrossRefPubMed

57.

Cao W, Xiao H, Lai X, Luo Y, Shi J, Tan Y, Zheng W, He J, Xie W, Li L et al: Genetic variations in the mycophenolate mofetil target enzyme are associated with acute GVHD risk after related and unrelated hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012, 18: 273-279. 10.1016/j.bbmt.2011.06.014.CrossRefPubMed

58.

Zhang C, Chen XH, Zhang X, Gao L, Kong PY, Peng XG, Liang X, Gong Y, Wang QY: Human umbilical cord blood-derived stromal cells, a new resource in the suppression of acute graft-versus-host disease in haploidentical stem cell transplantation in sublethally irradiated mice. J Biol Chem. 2011, 286: 13723-13732. 10.1074/jbc.M110.144691.PubMedCentralCrossRefPubMed

59.

Yang J, Fan H, Hao J, Ren Y, Chen L, Li G, Xie R, Yang Y, Qian K, Liu M: Amelioration of acute graft-versus-host disease by adoptive transfer of ex vivo expanded human cord blood CD4 + CD25+ forkhead box protein 3+ regulatory T cells is associated with the polarization of Treg/Th17 balance in a mouse model. Transfusion. 2011, doi: 10.1111/j.1537-2995.2011.03448.x

60.

Chen W, Li M, Li Z, Yan Z, Cheng H, Pan B, Cao J, Chen C, Zeng L, Xu K: CXCR4-transduced mesenchymal stem cells protect mice against graft-versus-host disease. Immunol Lett. 2012, doi:10.1016/j.imlet.2012.01.015

61.

Marks DI: Treating the "older" adult with acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program. 2010, 2010: 13-20. 10.1182/asheducation-2010.1.13.CrossRefPubMed

62.

Estey E, de Lima M, Tibes R, Pierce S, Kantarjian H, Champlin R, Giralt S: Prospective feasibility analysis of reduced-intensity conditioning (RIC) regimens for hematopoietic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). Blood. 2007, 109: 1395-1400. 10.1182/blood-2006-05-021907.CrossRefPubMed

63.

Guo M, Hu KX, Yu CL, Sun QY, Qiao JH, Wang DH, Liu GX, Sun WJ, Wei L, Sun XD et al: Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients. Blood. 2011, 117: 936-941. 10.1182/blood-2010-06-288506.CrossRefPubMed

Title: Allogeneic hematopoietic stem cell transplantation in China: where we are and where to go
Authors: Meng Lv
Xiao-Jun Huang
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2012
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/1756-8722-5-10

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2012

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide

Novel targeted agents for gastric cancer

Recognizing and managing the expanded risk of tumor lysis syndrome in hematologic and solid malignancies

EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis

The significance of low PU.1 expression in patients with acute promyelocytic leukemia

Arsenic trioxide improves hematopoiesis in refractory severe aplastic anemia

Keynote webinar | Spotlight on antibody–drug conjugates in cancer