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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2009

Open Access 01-12-2009 | Review

New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer

Authors: Shundong Cang, Yuehua Ma, Delong Liu

Published in: Journal of Hematology & Oncology | Issue 1/2009

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Abstract

DNA methylation and histone acetylation are two well known epigenetic chromatin modifications. Epigenetic agents leading to DNA hypomethylation and histone hyperacetylation have been approved for treatment of hematological disorders. The first histone deacetylase inhibitor, vorinostat, has been licensed for cutaneous T cell lymphoma treatment. More than 11 new epigenetic agents are in various stages of clinical development for therapy of multiple cancer types. In this review we summarize novel histone deacetylase inhibitors and new regimens from clinical trials for epigenetic therapy of cancer.
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Metadata
Title
New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer
Authors
Shundong Cang
Yuehua Ma
Delong Liu
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2009
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-2-22

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