Skip to main content
Top
Published in: International Journal of Mental Health Systems 1/2012

Open Access 01-12-2012 | Research

Schizophrenia in real life: courses, symptoms and functioning in an Italian population

Authors: Maria Cristina Turola, Gloria Comellini, Anna Galuppi, Maria Giulia Nanni, Emanuela Carantoni, Chiara Scapoli

Published in: International Journal of Mental Health Systems | Issue 1/2012

Login to get access

Abstract

Background

In the general belief, schizophrenia is associated with the concepts of seriousness, incurability, dangerousness: this is incorrect. In recent decades, the interest in course studies increased and different trends emerged, not necessarily chronic, with the possibility of remission.
The plan of this research was to draw a picture of the schizophrenia syndrome in a specific geographic area, in the past and at present time: this allows to detect needs, weaknesses and strengths, for a better planning of future interventions.

Methods

The course of all cases diagnosed as schizophrenia (N = 1,759) in the period 1978–2008, was retrospectively studied in the entire population of an Italian province by observing, for a mean period of 12 years per person, age at first psychiatric consultation, number and length of admissions for both acute symptoms and residential-rehabilitation programs, number of interventions in outpatients. The cases under treatment (N = 842), were evaluated in terms of symptoms, using the Brief Psychiatric Rating Scale, and in terms of functioning, using the Personal and Social Functioning Scale.

Results

The disease course differs significantly between genders: males have an earlier age at first consultation (about 7 years earlier), higher admission rates, greater number of outpatient interventions and personal and social functioning significantly worse.
Hospitalization resulted often unnecessary: 23.1% of cases were never hospitalized and 67.2% spent less than one week per year in hospital.
A quarter of the cases meets the international criteria for remission and more than 75% are asymptomatic or mildly symptomatic; only 5.3% of cases shows severe symptoms. However, Personal and Social Functioning highlights, in about 1/3 of cases, relevant or serious problems mainly in Work and Relationships areas, whilst Aggressiveness is a serious problem only in 9%.

Conclusions

In this population, schizophrenia in real life shows great individual variability in course, symptoms and functioning: in most cases nowadays it appears a less severe and chronic disease than in the past, but further improvements are needed on disability prevention and social inclusion.
Appendix
Available only for authorised users
Literature
2.
go back to reference DSM-IV-TR. The Diagnostic and Statistical Manual of Mental Disorders. Fourth edition, Text Revision. 2000, Washington: American Psychiatric Association DSM-IV-TR. The Diagnostic and Statistical Manual of Mental Disorders. Fourth edition, Text Revision. 2000, Washington: American Psychiatric Association
5.
go back to reference Bonfigli C: Lettere polemiche sulla pellagra. Raccoglitore medico. 1879, XI: 3- Bonfigli C: Lettere polemiche sulla pellagra. Raccoglitore medico. 1879, XI: 3-
7.
go back to reference Ciompi L: Catamnestic long-term studies on the course of life of schizophrenics. Schizophrenia Bull. 1980, 6: 606-618. 10.1093/schbul/6.4.606.CrossRef Ciompi L: Catamnestic long-term studies on the course of life of schizophrenics. Schizophrenia Bull. 1980, 6: 606-618. 10.1093/schbul/6.4.606.CrossRef
8.
go back to reference Leff J, Sartorius N, Jablensky A, Korten A, Emberg G: The International Pilot Study of Schizophrenia: five-year follow-up findings. Psychol Med. 1992, 22: 131-145. 10.1017/S0033291700032797.CrossRefPubMed Leff J, Sartorius N, Jablensky A, Korten A, Emberg G: The International Pilot Study of Schizophrenia: five-year follow-up findings. Psychol Med. 1992, 22: 131-145. 10.1017/S0033291700032797.CrossRefPubMed
9.
go back to reference Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, Day R, Bertelsen A: Schizophrenia:manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl. 1992, 20: 1-97.CrossRefPubMed Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, Day R, Bertelsen A: Schizophrenia:manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl. 1992, 20: 1-97.CrossRefPubMed
10.
go back to reference Mason P, Harrison G, Glazebrook C, Medley I, Croudace T: The course of schizophrenia over 13 years. a report from the International Study on Schizophrenia (ISoS) coordinated by the World Health Organization. Br J Psychiatry. 1996, 169: 580-586. 10.1192/bjp.169.5.580.CrossRefPubMed Mason P, Harrison G, Glazebrook C, Medley I, Croudace T: The course of schizophrenia over 13 years. a report from the International Study on Schizophrenia (ISoS) coordinated by the World Health Organization. Br J Psychiatry. 1996, 169: 580-586. 10.1192/bjp.169.5.580.CrossRefPubMed
11.
go back to reference Jobe HT: Long-term outcome of patients with schizophrenia: a review. Can J Psychiatry. 2005, 50: 892-900.PubMed Jobe HT: Long-term outcome of patients with schizophrenia: a review. Can J Psychiatry. 2005, 50: 892-900.PubMed
12.
go back to reference Ruggeri M, Lasalvia A, Tansella M, Bonetto C, Abate M, Thornicroft G, Allevi L, Ognibene P: Heterogeneity of outcomes in schizophrenia. 3-year follow-up of treated prevalent cases. Br J Psychiatry. 2004, 184: 48-57. 10.1192/bjp.184.1.48.CrossRefPubMed Ruggeri M, Lasalvia A, Tansella M, Bonetto C, Abate M, Thornicroft G, Allevi L, Ognibene P: Heterogeneity of outcomes in schizophrenia. 3-year follow-up of treated prevalent cases. Br J Psychiatry. 2004, 184: 48-57. 10.1192/bjp.184.1.48.CrossRefPubMed
14.
go back to reference Lasalvia A, Ruggeri M: Assessing the outcome of community-based psychiatric care: building a feedback loop from “real world” health services research into clinical practice. Acta Psychiatr Scand. 2007, 116 (suppl 437): 6-15.CrossRef Lasalvia A, Ruggeri M: Assessing the outcome of community-based psychiatric care: building a feedback loop from “real world” health services research into clinical practice. Acta Psychiatr Scand. 2007, 116 (suppl 437): 6-15.CrossRef
15.
go back to reference Andreasen NC, Carpenter WT, Kane JM, Lasser RA, Marder SR, Weinberger DR: Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry. 2005, 162 (3): 441-449. 10.1176/appi.ajp.162.3.441.CrossRefPubMed Andreasen NC, Carpenter WT, Kane JM, Lasser RA, Marder SR, Weinberger DR: Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry. 2005, 162 (3): 441-449. 10.1176/appi.ajp.162.3.441.CrossRefPubMed
17.
go back to reference Anthony WA: Recovery from Mental Illness: the guiding vision of the Mental Health Service System in the 1990s. Psychosoc Rehabil J. 1993, 16 (4): 11-23.CrossRef Anthony WA: Recovery from Mental Illness: the guiding vision of the Mental Health Service System in the 1990s. Psychosoc Rehabil J. 1993, 16 (4): 11-23.CrossRef
18.
go back to reference Jacobson N, Greenley D: What is recovery? A conceptual model and explication. Psychiatr Serv. 2001, 52: 482-485. 10.1176/appi.ps.52.4.482.CrossRefPubMed Jacobson N, Greenley D: What is recovery? A conceptual model and explication. Psychiatr Serv. 2001, 52: 482-485. 10.1176/appi.ps.52.4.482.CrossRefPubMed
19.
go back to reference Bellack AS: Scientific and consumer models of recovery in Schizophrenia: concordance, contrast and implications. Schizophr Bull. 2006, 32 (3): 432-442.PubMedCentralCrossRefPubMed Bellack AS: Scientific and consumer models of recovery in Schizophrenia: concordance, contrast and implications. Schizophr Bull. 2006, 32 (3): 432-442.PubMedCentralCrossRefPubMed
20.
go back to reference Andresen R, Oades L, Caputi P: The experience of recovery from schizophrenia: towards an empirically validated stage model. Aust NZ J Psychiat. 2003, 37: 586-594. 10.1046/j.1440-1614.2003.01234.x.CrossRef Andresen R, Oades L, Caputi P: The experience of recovery from schizophrenia: towards an empirically validated stage model. Aust NZ J Psychiat. 2003, 37: 586-594. 10.1046/j.1440-1614.2003.01234.x.CrossRef
21.
go back to reference De Salvia D, Barbato A, Salvo P, Zadro F: Prevalence and incidence of schizophrenic disorders in Portogruaro. An Italian case register study. J Nerv Ment Dis. 1993, 181 (5): 275-282.CrossRefPubMed De Salvia D, Barbato A, Salvo P, Zadro F: Prevalence and incidence of schizophrenic disorders in Portogruaro. An Italian case register study. J Nerv Ment Dis. 1993, 181 (5): 275-282.CrossRefPubMed
22.
go back to reference Overall JE, Girham DR: The brief psychiatric rating scale. Psychol Rep. 1961, 10: 799-812.CrossRef Overall JE, Girham DR: The brief psychiatric rating scale. Psychol Rep. 1961, 10: 799-812.CrossRef
23.
go back to reference Ventura J, Lukoff D, Nuechterlein KH, Liberman RP, Green M, Shaner A: Appendix 1: Brief psychiatric Rating Scale (BPRS) Expanded Version (4.0) scales, anchor points and administration manual. Int J Methods Psychiatr Res. 1993, 3: 227-243. Ventura J, Lukoff D, Nuechterlein KH, Liberman RP, Green M, Shaner A: Appendix 1: Brief psychiatric Rating Scale (BPRS) Expanded Version (4.0) scales, anchor points and administration manual. Int J Methods Psychiatr Res. 1993, 3: 227-243.
24.
go back to reference Morosini P, Roncone R, Impallomeni M, Casacchia M: Presentazione dell’adattamento italiano della brief psychiatric rating scale, versione 4.0 ampliata (bprs 4.0). Rivista di riabilitazione psichiatrica e psicosociale. 1994, 3 (94): 195-198. Morosini P, Roncone R, Impallomeni M, Casacchia M: Presentazione dell’adattamento italiano della brief psychiatric rating scale, versione 4.0 ampliata (bprs 4.0). Rivista di riabilitazione psichiatrica e psicosociale. 1994, 3 (94): 195-198.
25.
go back to reference Morosini P, Magliano L, Brambilla L, Ugolini S, Pioli R: Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social functioning. Acta Psychiatr Scand. 2000, 101: 323-329.PubMed Morosini P, Magliano L, Brambilla L, Ugolini S, Pioli R: Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social functioning. Acta Psychiatr Scand. 2000, 101: 323-329.PubMed
26.
go back to reference Gigantesco A, Vittorielli M, Pioli R, Falloon IRH, Rossi G, Morosini P: The VADO Approach in psychiatric rehabilitation; a randomized controlled trial. Psychiatr Serv. 2006, 57 (12): 1778-1783. 10.1176/appi.ps.57.12.1778.PubMed Gigantesco A, Vittorielli M, Pioli R, Falloon IRH, Rossi G, Morosini P: The VADO Approach in psychiatric rehabilitation; a randomized controlled trial. Psychiatr Serv. 2006, 57 (12): 1778-1783. 10.1176/appi.ps.57.12.1778.PubMed
27.
go back to reference Pioli R, Vittorielli M, Gigantesco A, Rossi G, Basso L, Caprioli C, Buizza C, Corradi A, Mirabella F, Morosini P, Falloon IRH: Outcome assessment of the VADO approach in psychiatric rehabilitation: a partially randomised multicentric trial. Clinical Practice and Epidemiology in Mental Health. 2006, 2: 5-10.1186/1745-0179-2-5.PubMedCentralCrossRefPubMed Pioli R, Vittorielli M, Gigantesco A, Rossi G, Basso L, Caprioli C, Buizza C, Corradi A, Mirabella F, Morosini P, Falloon IRH: Outcome assessment of the VADO approach in psychiatric rehabilitation: a partially randomised multicentric trial. Clinical Practice and Epidemiology in Mental Health. 2006, 2: 5-10.1186/1745-0179-2-5.PubMedCentralCrossRefPubMed
28.
go back to reference Cohen J: Statistical power analysis for the behavioral sciences. 1988, New York: Academic, 2 Cohen J: Statistical power analysis for the behavioral sciences. 1988, New York: Academic, 2
29.
go back to reference Sneath PHA, Sokal RR: Numerical taxonomy. 1973, W. H. Freeman & Co, San Francisco Sneath PHA, Sokal RR: Numerical taxonomy. 1973, W. H. Freeman & Co, San Francisco
30.
go back to reference Piccinelli M: Gomez Homen F: Gender differences in the epidemiology of affective disorders and schizophrenia. 1997, Geneva: World Health Organization Piccinelli M: Gomez Homen F: Gender differences in the epidemiology of affective disorders and schizophrenia. 1997, Geneva: World Health Organization
31.
go back to reference Harrow M, Sands JR, Silverstein ML, Goldberg JF: Course and outcome for Schizophrenia versus other psychotic patients: a longitudinal study. Schizophr Bull. 1997, 23 (2): 287-303. 10.1093/schbul/23.2.287.CrossRefPubMed Harrow M, Sands JR, Silverstein ML, Goldberg JF: Course and outcome for Schizophrenia versus other psychotic patients: a longitudinal study. Schizophr Bull. 1997, 23 (2): 287-303. 10.1093/schbul/23.2.287.CrossRefPubMed
32.
go back to reference DeSisto M, Harding CM, McCormick RV, Ashikaga T, Brooks GW: The maine and vermont three-decade studies of serious mental illness. Br J Psychiatry. 1995, 167: 331-342. 10.1192/bjp.167.3.331.CrossRefPubMed DeSisto M, Harding CM, McCormick RV, Ashikaga T, Brooks GW: The maine and vermont three-decade studies of serious mental illness. Br J Psychiatry. 1995, 167: 331-342. 10.1192/bjp.167.3.331.CrossRefPubMed
33.
go back to reference Sartorius N, Schulze H: Reducing the stigma of Mental Illness. 2005, Cambridge: Cambridge University PressCrossRef Sartorius N, Schulze H: Reducing the stigma of Mental Illness. 2005, Cambridge: Cambridge University PressCrossRef
Metadata
Title
Schizophrenia in real life: courses, symptoms and functioning in an Italian population
Authors
Maria Cristina Turola
Gloria Comellini
Anna Galuppi
Maria Giulia Nanni
Emanuela Carantoni
Chiara Scapoli
Publication date
01-12-2012
Publisher
BioMed Central
Published in
International Journal of Mental Health Systems / Issue 1/2012
Electronic ISSN: 1752-4458
DOI
https://doi.org/10.1186/1752-4458-6-22

Other articles of this Issue 1/2012

International Journal of Mental Health Systems 1/2012 Go to the issue