Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2014

Open Access 01-12-2014 | Case report

Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature

Authors: Μaria Νikoletta Protopapa, Dimitrios Velissaris, Athena Mougiou, Dimitrios Siagkris

Published in: Journal of Medical Case Reports | Issue 1/2014

Login to get access

Abstract

Introduction

Cytomegalovirus-associated thrombosis has been extensively reported in the medical literature, mainly in immune-compromised patients. However, the association with splenic infarcts has been rarely mentioned.

Case presentation

We report the case of a 38-year-old Caucasian man of Hellenic origin with acute cytomegalovirus infection presenting with spontaneous splenic infarcts. Echocardiography did not show any vegetations or mural thrombi. Anticoagulation treatment was not considered due to implication of minor vessels and since cytomegalovirus was the probable trigger for thrombosis in this patient.

Conclusions

This case report serves as additional evidence for the role of cytomegalovirus in thrombosis.
Appendix
Available only for authorised users
Literature
1.
Squizzato A, Gerdes VE, Buller HR: Effects of human cytomegalovirus infection on the coagulation system. Thromb Haemost. 2005, 93: 403-410.PubMed
2.
Justo D, Finn T, Atzmony L, Goy N, Steinvil A: Thrombosis associated with acute cytomegalovirus infection: a meta-analysis. Eur J Intern Med. 2011, 22: 195-199. 10.1016/j.ejim.2010.11.006.CrossRefPubMed
3.
Abgueguen P, Delbos V, Chennebault JM, Payan C, Pichard E: Vascular thrombosis and acute CMV infection in immunocompetent patients: report of 2 cases and literature review. Clin Infect Dis. 2003, 36: 134-138. 10.1086/374664.CrossRef
4.
Alcami J, Barzu T, Michelson S: Induction of an endothelial cell growth factor by human cytomegalovirus infection of fibroblasts. J Gen Virol. 1991, 72: 2765-2770. 10.1099/0022-1317-72-11-2765.CrossRefPubMed
5.
Span AH, Van Dam-Mieras MC, Mullers W: The effect of virus infection on the adherence of leukocytes or platelets to endothelial cells. Eur J Clin Invest. 1991, 21: 331-338. 10.1111/j.1365-2362.1991.tb01378.x.CrossRefPubMed
6.
Iwamoto GK, Monich MM, Clark BD, Auron PE, Stinski MF, Hunninghake G: Modulation of interleukin 1 beta gene expression by the immediate early genes of human cytomegalovirus. J Clin Invest. 1990, 85: 1853-1857. 10.1172/JCI114645.CrossRefPubMedPubMedCentral
7.
Smith PD, Saini SS, Raffeld M, Manischewitz JF, Wahl S: Cytomegalovirus induction of tumor necrosis factor-alpha by human monocytes and mucosal macrophages. J Clin Invest. 1992, 90: 1642-1648. 10.1172/JCI116035.CrossRefPubMedPubMedCentral
8.
Sforza D, Iaria G, Tariciotti L, Manuelli M, Anselmo A, Ciano P, Manzia TM, Toti L, Tisone G: Deep vein thrombosis as debut of cytomegalovirus infection associated with type II cryoglobulinemia, with antierythrocyte specificity in a kidney transplant recipient: a case report. Transplant Proc. 2013, 45: 2782-2784. 10.1016/j.transproceed.2013.07.004.CrossRefPubMed
9.
Etingin OR, Silverstein RL, Friedman HM, Hajjar DP: Viral activation of the coagulation cascade: molecular interactions at the surface of infected endothelial cells. Cell. 1990, 61: 657-662. 10.1016/0092-8674(90)90477-V.CrossRefPubMed
10.
Guermazi S, Regnault V, Gorgi Y, Ayed K, Lecompte T, Dellagi K: Further evidence for the presence of anti-protein S auto-antibodies in patients with systemic lupus erythematosus. Blood Coagul Fibrinolysis. 2000, 11: 491-498. 10.1097/00001721-200007000-00012.CrossRefPubMed
11.
Ofotokun I, Carlson C, Gitlin SD, Elta G, Singleton TP, Markovitz DM: Acute cytomegalovirus infection complicated by vascular thrombosis: a case report. Clin Infect Dis. 2001, 32: 983-986. 10.1086/319353.CrossRefPubMed
12.
Khater FJ, Myers JW, Moorman JP: A 45-year-old woman with fever and splenic infarcts. Clin Infect Dis. 2003, 37: 1093-10.1086/378295.CrossRefPubMed
13.
Poon MLM, Tang JW, Chee YL: Case report: cytomegalovirus-induced thrombosis in an immune-competent patient. J Med Virol. 2012, 84: 116-118. 10.1002/jmv.22253.CrossRefPubMed
14.
Justo D, Danylesko A, Shvedov V, Katzir M, Paran Y, Atzmony L, Kemelman P, Lerman Y: Cytomegalovirus colitis associated with arterial thromboembolism in an immunocompetent elderly man. J Am Geriatr Soc. 2010, 58: 405-406. 10.1111/j.1532-5415.2009.02710.x.CrossRefPubMed
15.
Atzmony L, Sear N, Chandadze T, Arbel Y, Justo D, Mashav N: Cytomegalovirus associated splenic infarcts in a female patient with factor V Leiden mutation: a case report. J Med Case Rep. 2008, 2: 385-10.1186/1752-1947-2-385.CrossRefPubMedPubMedCentral
16.
Jordan MC, Wyatt E, Rousseau WE, Stewart JA, Noble GR, Chin TDY: Spontaneous cytomegalovirus mononucleosis: clinical and laboratory observation in nine cases. Ann Intern Med. 1973, 79: 153-160. 10.7326/0003-4819-79-2-153.CrossRefPubMed
17.
Inacio C, Hillaire S, Valla D: Case report: cytomegalovirus infection as a cause of acute portal vein thrombosis. J Gastroenterol Hepatol. 1997, 12: 287-288. 10.1111/j.1440-1746.1997.tb00423.x.CrossRefPubMed
18.
De Celis G, Mir J, Casal J, Gomez D: 31-year-old woman with an enlarged tender liver. Lancet. 1997, 346: 1270CrossRef
19.
Arav-Boger R, Reif S, Bujanover Y: Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. J Pediatr. 1995, 126: 586-588. 10.1016/S0022-3476(95)70355-1.CrossRefPubMed
Metadata
Title
Cytomegalovirus-associated splenic infarcts in an adult immune-competent man: a case report and review of the literature
Authors
Μaria Νikoletta Protopapa
Dimitrios Velissaris
Athena Mougiou
Dimitrios Siagkris
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2014
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-8-85

Other articles of this Issue 1/2014

Journal of Medical Case Reports 1/2014 Go to the issue

Case report

A 4-month-old baby boy presenting with anaphylaxis to a banana: a case report

Case report

Migraine and tension-type headache treated with stromal vascular fraction: a case series

Case report

Treatment decisions in a man with Hodgkin lymphoma and Guillian-Barré syndrome: a case report

Case report

Cardiac tamponade masquerading as gastritis: a case report

Case report

Periodontal probing of an impacted tooth recovered through a surgical-orthodontic approach: a case report

Case report

Regression of vascular calcification following an acute episode of calciphylaxis: a case report