Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2012

Open Access 01-12-2012 | Case report

Lung cancer presenting as a metastasis to the carpal bones: a case report

Authors: Giuseppe Rinonapoli, Auro Caraffa, Renato Antenucci

Published in: Journal of Medical Case Reports | Issue 1/2012

Login to get access

Abstract

Introduction

A first metastasis to the hand is extremely rare. Usually, an acrometastasis is a sign of very advanced disease, with the presence of previous multiple metastases elsewhere. The present paper is one of the very few case reports of first metastatic location to carpal bones. To date, only Lederer et al., in 1990, and Song and Yao in 2012, have described a metastasis to the trapezium from lung cancer.

Case presentation

A 74-year-old Caucasian man was submitted to several physical examinations for thumb pain. The first diagnosis was tendonitis and the second diagnosis was thumb carpometacarpal osteoarthritis. Only when the patient was admitted to an internal medicine department for deterioration of his general condition and an enormous mass on his left hand was an open biopsy performed. It revealed a metastasis from large-cell lung carcinoma. A total-body scintigraphy and total-body computed tomography scan were negative for other secondary locations. The patient underwent an amputation at the distal third of the forearm.

Conclusion

Less than 20 case reports are available in the literature dealing with metastases to carpal bones. Very few cases are described as carpal metastases in the absence of other previous metastases, and only two articles, before the present one, have reported a metastasis to the trapezium. This case report teaches us two things: first, patient adherence to follow-up is extremely important; and, second, a thorough examination of diagnostic findings needs to be carried out at all times.
Appendix
Available only for authorised users
Literature
1.
go back to reference Aboulafia AJ, Aboulafia DM: Incidence, location and diagnostic evaluation of metastatic bone disease. Orthop Clin North Am. 2000, 31: 515-528. 10.1016/S0030-5898(05)70171-1.CrossRefPubMed Aboulafia AJ, Aboulafia DM: Incidence, location and diagnostic evaluation of metastatic bone disease. Orthop Clin North Am. 2000, 31: 515-528. 10.1016/S0030-5898(05)70171-1.CrossRefPubMed
4.
go back to reference Sparkes J: Upper limb bone metastases. Tech Orthop. 2004, 19: 9-14. 10.1097/00013611-200403000-00003.CrossRef Sparkes J: Upper limb bone metastases. Tech Orthop. 2004, 19: 9-14. 10.1097/00013611-200403000-00003.CrossRef
5.
go back to reference Rubens RD, Coleman RE: Bone metastases. Clinical Oncology. Edited by: Abeloff MD, Arnitage JO, Lichter AS. 1995, New York: Churchill Livingstone, 643-665. Rubens RD, Coleman RE: Bone metastases. Clinical Oncology. Edited by: Abeloff MD, Arnitage JO, Lichter AS. 1995, New York: Churchill Livingstone, 643-665.
6.
go back to reference Barrionuevo AM, Rillo OL: Distal skeletal metastases. J Clin Reum. 2006, 12: 148-150.CrossRef Barrionuevo AM, Rillo OL: Distal skeletal metastases. J Clin Reum. 2006, 12: 148-150.CrossRef
7.
go back to reference Flynn CJ, Danjoux CJ, Wong J, Christakis M, Rubenstein J, Yee A, Yip D, Chow E: Two cases of acrometastasis to the hands and review of the literature. Curr Oncol. 2008, 15: 51-58.PubMedPubMedCentral Flynn CJ, Danjoux CJ, Wong J, Christakis M, Rubenstein J, Yee A, Yip D, Chow E: Two cases of acrometastasis to the hands and review of the literature. Curr Oncol. 2008, 15: 51-58.PubMedPubMedCentral
8.
go back to reference Kerin R: The hand in metastatic disease. J Hand Surg (Am). 1987, 12: 77-83.CrossRef Kerin R: The hand in metastatic disease. J Hand Surg (Am). 1987, 12: 77-83.CrossRef
9.
go back to reference Cary PC: Metastatic disease to the carpus. Br J Radiol. 1981, 54: 992-995. 10.1259/0007-1285-54-647-992.CrossRefPubMed Cary PC: Metastatic disease to the carpus. Br J Radiol. 1981, 54: 992-995. 10.1259/0007-1285-54-647-992.CrossRefPubMed
10.
go back to reference Smith RJ: Involvement of the carpal bones with metastatic tumor. Am J Roentgenol Radium Ther Nucl Med. 1963, 89: 1253-1255.PubMed Smith RJ: Involvement of the carpal bones with metastatic tumor. Am J Roentgenol Radium Ther Nucl Med. 1963, 89: 1253-1255.PubMed
11.
go back to reference Lederer A, Flückiger F, Wildling R, Fruhwirth J: A solitary metastasis in the trapezium bone. Radiologe. 1990, 30: 79-80.PubMed Lederer A, Flückiger F, Wildling R, Fruhwirth J: A solitary metastasis in the trapezium bone. Radiologe. 1990, 30: 79-80.PubMed
12.
go back to reference Song Y, Yao J: Trapezial metastasis as the first indication of primary non-small cell carcinoma of the lung. J Hand Surg Am. 2012, 37: 1242-1244. 10.1016/j.jhsa.2012.03.006.CrossRefPubMed Song Y, Yao J: Trapezial metastasis as the first indication of primary non-small cell carcinoma of the lung. J Hand Surg Am. 2012, 37: 1242-1244. 10.1016/j.jhsa.2012.03.006.CrossRefPubMed
13.
go back to reference Colby TV, Koss MN, Travis WD: Tumors of Lower Respiratory Tract. 3rd series, Fascicle 13. 1995, Washington DC: Armed Forces Institute of Pathology Colby TV, Koss MN, Travis WD: Tumors of Lower Respiratory Tract. 3rd series, Fascicle 13. 1995, Washington DC: Armed Forces Institute of Pathology
14.
go back to reference DeVita VT, Lawrence TS, Rosenberg SA, De Pinho RA, Weinberg RZ: DeVita, Hellman, and Rosenberg's Cancer. Principles & Practice of Oncology. 2008, Philadelphia: Lippincott Williams & Wilkins, 8 DeVita VT, Lawrence TS, Rosenberg SA, De Pinho RA, Weinberg RZ: DeVita, Hellman, and Rosenberg's Cancer. Principles & Practice of Oncology. 2008, Philadelphia: Lippincott Williams & Wilkins, 8
15.
go back to reference Keshamouni V, Arenberg D, Kalemkerian G: Lung Cancer Metastases. Novel Biological Mechanisms and Impact on Clinical Practice. 2009, New York: Springer Keshamouni V, Arenberg D, Kalemkerian G: Lung Cancer Metastases. Novel Biological Mechanisms and Impact on Clinical Practice. 2009, New York: Springer
Metadata
Title
Lung cancer presenting as a metastasis to the carpal bones: a case report
Authors
Giuseppe Rinonapoli
Auro Caraffa
Renato Antenucci
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-6-384

Other articles of this Issue 1/2012

Journal of Medical Case Reports 1/2012 Go to the issue