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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2011

Open Access 01-12-2011 | Case report

Precocious puberty in an infant with hepatoblastoma: a case report

Authors: Usama Al-Jumaily, Ibrahim Sammour, Fadi Al-Muhaisen, Fatenah Ajlouni, Iyad Sultan

Published in: Journal of Medical Case Reports | Issue 1/2011

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Abstract

Introduction

The syndrome of isosexual precocious puberty associated with primary malignant hepatic tumors is rare. All previously reported cases in the literature are old and prognosis was grim.

Case presentation

We present the case of a 15-month-old Asian male baby who presented with precocious puberty associated with hepatoblastoma. Serum concentrations of alpha-fetoprotein and free testosterone were elevated, as was beta human chorionic gonadotropin hormone. He was treated with six courses of chemotherapy and underwent surgery. His surface markers as well as free testosterone level returned to normal during therapy. The child has now been off therapy for 18 months with no evidence of tumor recurrence at follow-up.

Conclusion

Virilizing hepatoblastoma is rare and reported with poor outcome, but the development of new chemotherapeutic agents and complete surgical resection are promising.
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Metadata
Title
Precocious puberty in an infant with hepatoblastoma: a case report
Authors
Usama Al-Jumaily
Ibrahim Sammour
Fadi Al-Muhaisen
Fatenah Ajlouni
Iyad Sultan
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2011
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-5-422

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