Abstract
We here describe a 2.5 year old boy with a virilizing unresectable hepatoblastoma. Administration of cisplatin in combination with vincristine and 5-fluorouracil every third week was shown to be very effective and rendered the tumour resectable.
Abbreviations
- AFP:
-
alpha-fetoprotein
- hCG:
-
human chorion gonadotropin
- 5-FU:
-
5-fluorouracil
References
Douglass EC, Green AA, Wrenn E, Champion J, Shipp M, Pratt CB (1985) Effective cisplatin (DDP) based chemotherapy in the treatment of hepatoblastoma. Med Pediatr Oncol 13:187–190
Evans AE, Land VJ, Newton WA, Randolph JG, Sather HN, Tefft M (1982) Combination chemotherapy (vincristin, adriamycin, cyclophosphamide, and 5-fluorouracil) in the treatment of children with malignant hepatoma. Cancer 50:821–826
Hermann RE, Lonsdale D (1970) Chemotherapy, radiotherapy, and hepatic lobectomy for hepatoblastoma in an infant: report of a survival. Surgery 68:383–388
Ikeda K, Suita S, Nakagawara A (1979) Preoperative chemotherapy for initially uncresectable hepatoblastoma in children. Arch Surg 114:203–207
Nakagawara A, Ikeda K, Tsuneyoshi M, Daimaru Y, Enjoji M, Watanabe I, Iwafuchi M, Sawada T (1985) Hepatoblastoma producing both alpha-fetoprotein and human chorion gonadotropin. Cancer 56:1636–1642
Navarro C, Corretger JM, Sancho A, Rovira J, Morales L (1985) Paraneoplastic precocious puberty. Cancer 56:1725–1729
Quinn JJ, Altman AJ, Robinson T, Cooke RW, Hight DW, Foster JH (1985) Adriamycin and cisplating for hepatoblastoma. Cancer 56:1926–1929
Randolph J, Chandra R, Leiken S (1980) Malignant liver tumors in infants and children. World J Surg 4:71–82
Shafer AD, Selinkoff PM (1971) Preoperative irradiation and chemotherapy for initially unresectable hepatoblastoma. J Pediatr Surg 12:1001–1007
Weinberg AG, Finegold MJ (1983) Primary hepatic tumors of childhood. Hum Pathol 14:512–537
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Herlin, T., Norup, K. & Storm, K. Treatment of unresectable hepatoblastoma with cisplatin, vincristin and 5-fluorouracil. Eur J Pediatr 147, 514–515 (1988). https://doi.org/10.1007/BF00441977
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00441977