Skip to main content
Top
Published in: Journal of Medical Case Reports 1/2011

Open Access 01-12-2011 | Case report

Primary malignant mixed Müllerian tumor arising from the mesorectum with a synchronous ovarian cancer: a case report and review of the literature

Authors: Chuang-Chi Huang, Cheng-Jen Ma, Wan-Ting Huang, Te-Fu Chan, Jaw-Yuan Wang

Published in: Journal of Medical Case Reports | Issue 1/2011

Login to get access

Abstract

Introduction

Extragenital malignant mixed Müllerian tumor is an extremely rare presentation of malignant mixed Müllerian tumor, especially when combined with a synchronous ovarian cancer.

Case presentation

We report the clinical course and pathologic findings of a case of mesorectal malignant mixed Müllerian tumor with synchronous ovarian cancer, in a 50-year-old, gravida 0, para 0, Han Chinese woman with regular menstruation. This is the sixteenth case in the English literature of extragenital malignant mixed Müllerian tumor combined with synchronous or metachronous malignancy reported.

Conclusion

Although extragenital malignant mixed Müllerian tumor is very rare and has a poor prognososis, a longer survival time might be achieved with treatment by cytoreductive surgery, radiotherapy and chemotherapy.
Appendix
Available only for authorised users
Literature
1.
go back to reference Ma CJ, Yang SF, Huang CC, Chai CY, Cheng KI, Tsai EM, Wang JY: Malignant mixed Müllerian tumor of primary mesenteric origin associated with a synchronous ovarian cancer. Eur J Gynaecol Oncol. 2008, 29: 289-293.PubMed Ma CJ, Yang SF, Huang CC, Chai CY, Cheng KI, Tsai EM, Wang JY: Malignant mixed Müllerian tumor of primary mesenteric origin associated with a synchronous ovarian cancer. Eur J Gynaecol Oncol. 2008, 29: 289-293.PubMed
2.
go back to reference Swerdlow M: Mesothelioma of the pelvic peritoneum resembling papillary cystadenocarcinoma of the ovary; case report. Am J Obstet Gynecol. 1959, 77: 197-200.CrossRefPubMed Swerdlow M: Mesothelioma of the pelvic peritoneum resembling papillary cystadenocarcinoma of the ovary; case report. Am J Obstet Gynecol. 1959, 77: 197-200.CrossRefPubMed
3.
go back to reference Bloss JD, Liao SY, Buller RE, Manetta A, Berman ML, McMeekin S, Bloss LP, DiSaia PJ: Extraovarian peritoneal serous papillary carcinoma: a case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol. 1993, 50: 347-351. 10.1006/gyno.1993.1223.CrossRefPubMed Bloss JD, Liao SY, Buller RE, Manetta A, Berman ML, McMeekin S, Bloss LP, DiSaia PJ: Extraovarian peritoneal serous papillary carcinoma: a case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol. 1993, 50: 347-351. 10.1006/gyno.1993.1223.CrossRefPubMed
4.
go back to reference Look M, Chang D, Sugarbaker PH: Long-term results of cytoreductive surgery for advanced and recurrent epithelial ovarian cancers and papillary serous carcinoma of the peritoneum. Int J Gynecol Cancer. 2004, 12: 35-41. 10.1111/j.1048-891x.2004.14008.x.CrossRef Look M, Chang D, Sugarbaker PH: Long-term results of cytoreductive surgery for advanced and recurrent epithelial ovarian cancers and papillary serous carcinoma of the peritoneum. Int J Gynecol Cancer. 2004, 12: 35-41. 10.1111/j.1048-891x.2004.14008.x.CrossRef
5.
go back to reference Zhang C, Li XP, Cui H, Shen DH, Wei LH: Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. J Zhejiang Univ Sci B. 2008, 9: 435-440. 10.1631/jzus.B0820051.CrossRefPubMedPubMedCentral Zhang C, Li XP, Cui H, Shen DH, Wei LH: Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. J Zhejiang Univ Sci B. 2008, 9: 435-440. 10.1631/jzus.B0820051.CrossRefPubMedPubMedCentral
6.
go back to reference Ober WB, Black MB: Neoplasms of the subcoelomic mesenchyme; report of two cases. AMA Arch Pathol. 1955, 59: 698-705.PubMed Ober WB, Black MB: Neoplasms of the subcoelomic mesenchyme; report of two cases. AMA Arch Pathol. 1955, 59: 698-705.PubMed
7.
go back to reference Simon S, Wang SE, Shackney S: Complete response of carcinosarcoma of the ovary to therapy with doxorubicin, ifosfamide and dacarbazine. Gynecol Oncol. 1991, 41: 161-166. 10.1016/0090-8258(91)90278-D.CrossRefPubMed Simon S, Wang SE, Shackney S: Complete response of carcinosarcoma of the ovary to therapy with doxorubicin, ifosfamide and dacarbazine. Gynecol Oncol. 1991, 41: 161-166. 10.1016/0090-8258(91)90278-D.CrossRefPubMed
8.
go back to reference Sit AS, Price FV, Kelley JL, Comerd JT, Kunschner AJ, Kanbour-Shakir A, Edwards RP: Chemotherapy for malignant mixed Müllerian tumors of the ovary. Gynecol Oncol. 2000, 79: 196-200. 10.1006/gyno.2000.5956.CrossRefPubMed Sit AS, Price FV, Kelley JL, Comerd JT, Kunschner AJ, Kanbour-Shakir A, Edwards RP: Chemotherapy for malignant mixed Müllerian tumors of the ovary. Gynecol Oncol. 2000, 79: 196-200. 10.1006/gyno.2000.5956.CrossRefPubMed
9.
go back to reference Garamvoelgyi E, Guillou L, Gebhard S, Salmeron M, Seematter RJ, Hadji MH: Primary malignant mixed Müllerian tumor (metaplastic carcinoma) of the female peritoneum. A clinical, pathologic, and immunohistochemical study of three cases and a review of the literature. Cancer. 1994, 74: 854-863. 10.1002/1097-0142(19940801)74:3<854::AID-CNCR2820740311>3.0.CO;2-R.CrossRefPubMed Garamvoelgyi E, Guillou L, Gebhard S, Salmeron M, Seematter RJ, Hadji MH: Primary malignant mixed Müllerian tumor (metaplastic carcinoma) of the female peritoneum. A clinical, pathologic, and immunohistochemical study of three cases and a review of the literature. Cancer. 1994, 74: 854-863. 10.1002/1097-0142(19940801)74:3<854::AID-CNCR2820740311>3.0.CO;2-R.CrossRefPubMed
10.
go back to reference Müller H, Nakchbandi V: Cytoreductive surgery plus intraperitoneal hyperthermic perfusion is an effective treatment for metastasized malignant mixed mesodermal tumours (MMMT) - report of six cases. Eur J Surg Oncol. 2004, 30: 573-577.CrossRefPubMed Müller H, Nakchbandi V: Cytoreductive surgery plus intraperitoneal hyperthermic perfusion is an effective treatment for metastasized malignant mixed mesodermal tumours (MMMT) - report of six cases. Eur J Surg Oncol. 2004, 30: 573-577.CrossRefPubMed
11.
go back to reference Levine DA, Argenta PA, Yee CJ, Marshall DS, Olvera N, Bogomolniy F, Rohaman JA, Robson ME, Offit K, Barakat RR: Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. Clin Oncol. 2003, 21: 4222-4227. 10.1200/JCO.2003.04.131.CrossRef Levine DA, Argenta PA, Yee CJ, Marshall DS, Olvera N, Bogomolniy F, Rohaman JA, Robson ME, Offit K, Barakat RR: Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. Clin Oncol. 2003, 21: 4222-4227. 10.1200/JCO.2003.04.131.CrossRef
12.
go back to reference Mikami Y, Hata S, Kiyokawa T, Manabe T: Expression of CD10 in malignant Müllerian mixed tumors and adenosarcomas: an immunohistochemical study. Mod Pathol. 2002, 15: 923-930. 10.1097/01.MP.0000026058.33869.DB.CrossRefPubMed Mikami Y, Hata S, Kiyokawa T, Manabe T: Expression of CD10 in malignant Müllerian mixed tumors and adenosarcomas: an immunohistochemical study. Mod Pathol. 2002, 15: 923-930. 10.1097/01.MP.0000026058.33869.DB.CrossRefPubMed
13.
go back to reference Gallardo A, Prat J: Müllerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. Am J Surg. 2008, 20: 278-288. Gallardo A, Prat J: Müllerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. Am J Surg. 2008, 20: 278-288.
14.
go back to reference Ozguroglu M, Bilici A, Ilvan S, Turna H, Atalay B, Mandel N, Sahinler I: Determining predominating histological component in malignant mixed Müllerian tumors: is it worth it?. Int J Gynecol Cancer. 2008, 18: 809-812. 10.1111/j.1525-1438.2007.01074.x.CrossRefPubMed Ozguroglu M, Bilici A, Ilvan S, Turna H, Atalay B, Mandel N, Sahinler I: Determining predominating histological component in malignant mixed Müllerian tumors: is it worth it?. Int J Gynecol Cancer. 2008, 18: 809-812. 10.1111/j.1525-1438.2007.01074.x.CrossRefPubMed
15.
go back to reference Herman CW, Tessler AN: Extragenital mixed heterologous tumor of Müllerian type arising in retroperitoneum. Urology. 1983, 22: 49-50. 10.1016/0090-4295(83)90346-1.CrossRefPubMed Herman CW, Tessler AN: Extragenital mixed heterologous tumor of Müllerian type arising in retroperitoneum. Urology. 1983, 22: 49-50. 10.1016/0090-4295(83)90346-1.CrossRefPubMed
16.
go back to reference Chen KT, Wolk RW: Extragenital malignant mixed Müllerian tumor. Gynecol Oncol. 1988, 30: 422-426. 10.1016/0090-8258(88)90257-0.CrossRefPubMed Chen KT, Wolk RW: Extragenital malignant mixed Müllerian tumor. Gynecol Oncol. 1988, 30: 422-426. 10.1016/0090-8258(88)90257-0.CrossRefPubMed
17.
go back to reference El-Jabbour JN, Helm CW, McLaren KM, Smart GE, Aitken J: Synchronous colonic adenocarcinoma and extragenital malignant mixed mesodermal tumour. Scott Med J. 1989, 34: 567-568.PubMed El-Jabbour JN, Helm CW, McLaren KM, Smart GE, Aitken J: Synchronous colonic adenocarcinoma and extragenital malignant mixed mesodermal tumour. Scott Med J. 1989, 34: 567-568.PubMed
18.
go back to reference Garde JR, Jones MA, McAfee R, Tarraza HM: Extragenital malignant mixed Müllerian tumor: review of the literature. Gynecol Oncol. 1991, 43: 186-190. 10.1016/0090-8258(91)90070-L.CrossRefPubMed Garde JR, Jones MA, McAfee R, Tarraza HM: Extragenital malignant mixed Müllerian tumor: review of the literature. Gynecol Oncol. 1991, 43: 186-190. 10.1016/0090-8258(91)90070-L.CrossRefPubMed
19.
go back to reference Solis OG, Bui HX, Malfetano JH, Ross JS: Extragenital primary mixed malignant mesodermal tumor. Gynecol Oncol. 1991, 43: 182-185. 10.1016/0090-8258(91)90069-H.CrossRefPubMed Solis OG, Bui HX, Malfetano JH, Ross JS: Extragenital primary mixed malignant mesodermal tumor. Gynecol Oncol. 1991, 43: 182-185. 10.1016/0090-8258(91)90069-H.CrossRefPubMed
20.
go back to reference Mira JL, Fenoglio-Preiser CM, Husseinzadeh N: Malignant mixed Müllerian tumor of the extraovarian secondary Müllerian system. Report of two cases and review of the English literature. Arch Pathol Lab Med. 1995, 119: 1044-1049.PubMed Mira JL, Fenoglio-Preiser CM, Husseinzadeh N: Malignant mixed Müllerian tumor of the extraovarian secondary Müllerian system. Report of two cases and review of the English literature. Arch Pathol Lab Med. 1995, 119: 1044-1049.PubMed
21.
go back to reference Rose PG, Rodriguez M, Abdul-Karim FW: Malignant mixed Müllerian tumor of the female peritoneum: treatment and outcome of three cases. Gynecol Oncol. 1997, 65: 523-525. 10.1006/gyno.1997.4716.CrossRefPubMed Rose PG, Rodriguez M, Abdul-Karim FW: Malignant mixed Müllerian tumor of the female peritoneum: treatment and outcome of three cases. Gynecol Oncol. 1997, 65: 523-525. 10.1006/gyno.1997.4716.CrossRefPubMed
22.
go back to reference Shen DH, Khoo US, Xue WC, Ngan HY, Wang JL, Liu VW, Chan YK, Cheung AN: Primary peritoneal malignant mixed Müllerian tumors. A clinicopathologic, immunohistochemical, and genetic study. Cancer. 2001, 91: 1052-1060. 10.1002/1097-0142(20010301)91:5<1052::AID-CNCR1097>3.0.CO;2-A.CrossRefPubMed Shen DH, Khoo US, Xue WC, Ngan HY, Wang JL, Liu VW, Chan YK, Cheung AN: Primary peritoneal malignant mixed Müllerian tumors. A clinicopathologic, immunohistochemical, and genetic study. Cancer. 2001, 91: 1052-1060. 10.1002/1097-0142(20010301)91:5<1052::AID-CNCR1097>3.0.CO;2-A.CrossRefPubMed
23.
go back to reference Mikami M, Kuwabara Y, Tanaka K, Komiyama S, Ishikawa M, Hirose T: Malignant mixed Müllerian tumor of primary mesenteric origin. Int J Gynecol Cancer. 2005, 15: 1249-1253. 10.1111/j.1525-1438.2005.00192.x.CrossRefPubMed Mikami M, Kuwabara Y, Tanaka K, Komiyama S, Ishikawa M, Hirose T: Malignant mixed Müllerian tumor of primary mesenteric origin. Int J Gynecol Cancer. 2005, 15: 1249-1253. 10.1111/j.1525-1438.2005.00192.x.CrossRefPubMed
24.
go back to reference Shaco-Levy R, Sion-Vardy N, Piura B: Primary peritoneal malignant mixed Müllerian tumor associated with colonic adenocarcinoma. Eur J Gynaecol Oncol. 2005, 26: 509-510.PubMed Shaco-Levy R, Sion-Vardy N, Piura B: Primary peritoneal malignant mixed Müllerian tumor associated with colonic adenocarcinoma. Eur J Gynaecol Oncol. 2005, 26: 509-510.PubMed
Metadata
Title
Primary malignant mixed Müllerian tumor arising from the mesorectum with a synchronous ovarian cancer: a case report and review of the literature
Authors
Chuang-Chi Huang
Cheng-Jen Ma
Wan-Ting Huang
Te-Fu Chan
Jaw-Yuan Wang
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2011
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-5-15

Other articles of this Issue 1/2011

Journal of Medical Case Reports 1/2011 Go to the issue