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Molecular Neurodegeneration

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Open Access 01-12-2012 | Research article

Rapid glutamate receptor 2 trafficking during retinal degeneration

Authors: Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc

Published in: Molecular Neurodegeneration | Issue 1/2012

Abstract

Background

Retinal degenerations, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), are characterized by photoreceptor loss and anomalous remodeling of the surviving retina that corrupts visual processing and poses a barrier to late-stage therapeutic interventions in particular. However, the molecular events associated with retinal remodeling remain largely unknown. Given our prior evidence of ionotropic glutamate receptor (iGluR) reprogramming in retinal degenerations, we hypothesized that the edited glutamate receptor 2 (GluR2) subunit and its trafficking may be modulated in retinal degenerations.

Results

Adult albino Balb/C mice were exposed to intense light for 24 h to induce light-induced retinal degeneration (LIRD). We found that prior to the onset of photoreceptor loss, protein levels of GluR2 and related trafficking proteins, including glutamate receptor-interacting protein 1 (GRIP1) and postsynaptic density protein 95 (PSD-95), were rapidly increased. LIRD triggered neuritogenesis in photoreceptor survival regions, where GluR2 and its trafficking proteins were expressed in the anomalous dendrites. Immunoprecipitation analysis showed interaction between KIF3A and GRIP1 as well as PSD-95, suggesting that KIF3A may mediate transport of GluR2 and its trafficking proteins to the novel dendrites. However, in areas of photoreceptor loss, GluR2 along with its trafficking proteins nearly vanished in retracted retinal neurites.

Conclusions

All together, LIRD rapidly triggers GluR2 plasticity, which is a potential mechanism behind functionally phenotypic revisions of retinal neurons and neuritogenesis during retinal degenerations.

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Title: Rapid glutamate receptor 2 trafficking during retinal degeneration
Authors: Yanhua Lin
Bryan W Jones
Aihua Liu
Félix R Vazquéz-Chona
J Scott Lauritzen
W Drew Ferrell
Robert E Marc
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Molecular Neurodegeneration / Issue 1/2012
Electronic ISSN: 1750-1326
DOI: https://doi.org/10.1186/1750-1326-7-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Rapid glutamate receptor 2 trafficking during retinal degeneration

Abstract

Background

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusions

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