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Published in: World Journal of Emergency Surgery 1/2013

Open Access 01-12-2013 | Research article

Peritoneal adhesion index (PAI): proposal of a score for the “ignored iceberg” of medicine and surgery

Authors: Federico Coccolini, Luca Ansaloni, Roberto Manfredi, Luca Campanati, Elia Poiasina, Paolo Bertoli, Michela Giulii Capponi, Massimo Sartelli, Salomone Di Saverio, Michele Cucchi, Daniel Lazzareschi, Michele Pisano, Fausto Catena

Published in: World Journal of Emergency Surgery | Issue 1/2013

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Abstract

Peritoneal adhesions describe a condition in which pathological bonds form between the omentum, the small and large bowels, the abdominal wall, and other intra-abdominal organs. Different classification systems have been proposed, but they do not resolve the underlying problem of ambiguity in the quantification and definition of adhesions. We therefore propose a standardized classification system of adhesions to universalize their definition based on the macroscopic appearance of adhesions and their diffusion to different regions of the abdomen. By scoring with these criteria, the peritoneal adhesion index (PAI) can range from 0 to 30, unambiguously specifying precise adhesion scenarios. The standardized classification and quantification of adhesions would enable different studies to more meaningfully integrate their results, thereby facilitating a more comprehensive approach to the treatment and management of this pathology.
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Literature
1.
go back to reference Diamond MP, Freeman ML: Clinical implications of postsurgical adhesions. Hum Reprod Update. 2001, 7: 567-576. 10.1093/humupd/7.6.567.CrossRefPubMed Diamond MP, Freeman ML: Clinical implications of postsurgical adhesions. Hum Reprod Update. 2001, 7: 567-576. 10.1093/humupd/7.6.567.CrossRefPubMed
2.
go back to reference Arung W, Meurisse M, Detry O: Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol. 2011, 17: 4545-4553. 10.3748/wjg.v17.i41.4545.PubMedCentralCrossRefPubMed Arung W, Meurisse M, Detry O: Pathophysiology and prevention of postoperative peritoneal adhesions. World J Gastroenterol. 2011, 17: 4545-4553. 10.3748/wjg.v17.i41.4545.PubMedCentralCrossRefPubMed
3.
go back to reference Sulaiman H, Gabella G, Davis MSc C, Mutsaers SE, Boulos P, Laurent GJ, Herrick SE: Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Ann Surg. 2001, 234: 256-261. 10.1097/00000658-200108000-00016.PubMedCentralCrossRefPubMed Sulaiman H, Gabella G, Davis MSc C, Mutsaers SE, Boulos P, Laurent GJ, Herrick SE: Presence and distribution of sensory nerve fibers in human peritoneal adhesions. Ann Surg. 2001, 234: 256-261. 10.1097/00000658-200108000-00016.PubMedCentralCrossRefPubMed
4.
go back to reference Ellis H: The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl. 1997, 577: 5-9.PubMed Ellis H: The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl. 1997, 577: 5-9.PubMed
5.
go back to reference Pouly JL, Seak-San S: Adhesions: laparoscopy versus laparotomy. Peritoneal surgery. Edited by: DiZerega GS. 2000, Springer, New York, 183-192.CrossRef Pouly JL, Seak-San S: Adhesions: laparoscopy versus laparotomy. Peritoneal surgery. Edited by: DiZerega GS. 2000, Springer, New York, 183-192.CrossRef
6.
go back to reference Diamond MP: Reduction of de novo postsurgical adhesions by intraoperative precoating with sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The sepracoat adhesion study group. Fertil Steril. 1998, 69: 1067-1074. 10.1016/S0015-0282(98)00057-0.CrossRefPubMed Diamond MP: Reduction of de novo postsurgical adhesions by intraoperative precoating with sepracoat (HAL-C) solution: a prospective, randomized, blinded, placebo-controlled multicenter study. The sepracoat adhesion study group. Fertil Steril. 1998, 69: 1067-1074. 10.1016/S0015-0282(98)00057-0.CrossRefPubMed
7.
go back to reference Zühlke HV, Lorenz EM, Straub EM, Savvas V: Pathophysiology and classification of adhesions. Langenbecks Arch Chir Verh Dtsch Ges Chir. 1990, Suppl 2: 1009-1016. Zühlke HV, Lorenz EM, Straub EM, Savvas V: Pathophysiology and classification of adhesions. Langenbecks Arch Chir Verh Dtsch Ges Chir. 1990, Suppl 2: 1009-1016.
8.
go back to reference Parker MC, Wilson MS, van Goor H, Moran BJ, Jeekel J, Duron JJ, Menzies D, Wexner SD, Ellis H: Adhesions and colorectal surgery - call for action. Colorectal Dis. 2007, 9 (Suppl 2): 66-72.CrossRefPubMed Parker MC, Wilson MS, van Goor H, Moran BJ, Jeekel J, Duron JJ, Menzies D, Wexner SD, Ellis H: Adhesions and colorectal surgery - call for action. Colorectal Dis. 2007, 9 (Suppl 2): 66-72.CrossRefPubMed
9.
go back to reference Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL: Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001, 18: 260-273. 10.1159/000050149.CrossRefPubMed Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL: Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 2001, 18: 260-273. 10.1159/000050149.CrossRefPubMed
10.
go back to reference Cheong YC, Laird SM, Li TC, Shelton JB, Ledger WL, Cooke ID: Peritoneal healing and adhesion formation/reformation. Hum Reprod Update. 2001, 7: 556-566. 10.1093/humupd/7.6.556.CrossRefPubMed Cheong YC, Laird SM, Li TC, Shelton JB, Ledger WL, Cooke ID: Peritoneal healing and adhesion formation/reformation. Hum Reprod Update. 2001, 7: 556-566. 10.1093/humupd/7.6.556.CrossRefPubMed
11.
go back to reference Kössi J, Salminen P, Rantala A, Laato M: Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions. Br J Surg. 2003, 90: 1441-1444. 10.1002/bjs.4272.CrossRefPubMed Kössi J, Salminen P, Rantala A, Laato M: Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions. Br J Surg. 2003, 90: 1441-1444. 10.1002/bjs.4272.CrossRefPubMed
12.
go back to reference Menzies D, Ellis H: Intestinal obstruction from adhesions–how big is the problem?. Ann R Coll Surg Engl. 1990, 72: 60-63.PubMedCentralPubMed Menzies D, Ellis H: Intestinal obstruction from adhesions–how big is the problem?. Ann R Coll Surg Engl. 1990, 72: 60-63.PubMedCentralPubMed
13.
go back to reference Gutt CN, Oniu T, Schemmer P, Mehrabi A, Büchler MW: Fewer adhesions induced by laparoscopic surgery?. Surg Endosc. 2004, 18: 898-906. 10.1007/s00464-003-9233-3.CrossRefPubMed Gutt CN, Oniu T, Schemmer P, Mehrabi A, Büchler MW: Fewer adhesions induced by laparoscopic surgery?. Surg Endosc. 2004, 18: 898-906. 10.1007/s00464-003-9233-3.CrossRefPubMed
14.
go back to reference Krähenbühl L, Schäfer M, Kuzinkovas V, Renzulli P, Baer HU, Büchler MW: Experimental study of adhesion formation in open and laparoscopic fundoplication. Br J Surg. 1998, 85: 826-830. 10.1046/j.1365-2168.1998.00718.x.CrossRefPubMed Krähenbühl L, Schäfer M, Kuzinkovas V, Renzulli P, Baer HU, Büchler MW: Experimental study of adhesion formation in open and laparoscopic fundoplication. Br J Surg. 1998, 85: 826-830. 10.1046/j.1365-2168.1998.00718.x.CrossRefPubMed
15.
go back to reference Garrard CL, Clements RH, Nanney L, Davidson JM, Richards WO: Adhesion formation is reduced after laparoscopic surgery. Surg Endosc. 1999, 13: 10-13. 10.1007/s004649900887.CrossRefPubMed Garrard CL, Clements RH, Nanney L, Davidson JM, Richards WO: Adhesion formation is reduced after laparoscopic surgery. Surg Endosc. 1999, 13: 10-13. 10.1007/s004649900887.CrossRefPubMed
16.
go back to reference Polymeneas G, Theodosopoulos T, Stamatiadis A, Kourias E: A comparative study of postoperative adhesion formation after laparoscopic vs open cholecystectomy. Surg Endosc. 2001, 15: 41-43. 10.1007/s004640000269.CrossRefPubMed Polymeneas G, Theodosopoulos T, Stamatiadis A, Kourias E: A comparative study of postoperative adhesion formation after laparoscopic vs open cholecystectomy. Surg Endosc. 2001, 15: 41-43. 10.1007/s004640000269.CrossRefPubMed
17.
go back to reference Molinaro F, Kaselas C, Lacreuse I, Moog R, Becmeur F: Postoperative intestinal obstruction after laparoscopic versus open surgery in the pediatric population: A 15-year review. Eur J Pediatr Surg. 2009, 19: 160-162. 10.1055/s-0029-1202858.CrossRefPubMed Molinaro F, Kaselas C, Lacreuse I, Moog R, Becmeur F: Postoperative intestinal obstruction after laparoscopic versus open surgery in the pediatric population: A 15-year review. Eur J Pediatr Surg. 2009, 19: 160-162. 10.1055/s-0029-1202858.CrossRefPubMed
18.
go back to reference Dijkstra FR, Nieuwenhuijzen M, Reijnen MM, van Goor H: Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intra-abdominal adhesions. Scand J Gastroenterol Suppl. 2000, 232: 52-59.PubMed Dijkstra FR, Nieuwenhuijzen M, Reijnen MM, van Goor H: Recent clinical developments in pathophysiology, epidemiology, diagnosis and treatment of intra-abdominal adhesions. Scand J Gastroenterol Suppl. 2000, 232: 52-59.PubMed
19.
go back to reference Al-Jaroudi D, Tulandi T: Adhesion prevention in gynecologic surgery. Obstet Gynecol Surv. 2004, 59: 360-367. 10.1097/00006254-200405000-00024.CrossRefPubMed Al-Jaroudi D, Tulandi T: Adhesion prevention in gynecologic surgery. Obstet Gynecol Surv. 2004, 59: 360-367. 10.1097/00006254-200405000-00024.CrossRefPubMed
20.
go back to reference Alpay Z, Saed GM, Diamond MP: Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig. 2006, 13: 390-398. 10.1016/j.jsgi.2006.05.002.CrossRefPubMed Alpay Z, Saed GM, Diamond MP: Female infertility and free radicals: potential role in adhesions and endometriosis. J Soc Gynecol Investig. 2006, 13: 390-398. 10.1016/j.jsgi.2006.05.002.CrossRefPubMed
21.
go back to reference Trimbos-Kemper TC, Trimbos JB, van Hall EV: Adhesion formation after tubal surgery: results of the eighth-day laparoscopy in 188 patients. Fertil Steril. 1985, 43: 395-400.PubMed Trimbos-Kemper TC, Trimbos JB, van Hall EV: Adhesion formation after tubal surgery: results of the eighth-day laparoscopy in 188 patients. Fertil Steril. 1985, 43: 395-400.PubMed
22.
go back to reference Kresch AJ, Seifer DB, Sachs LB, Barrese I: Laparoscopy in 100 women with chronic pelvic pain. Obstet Gynecol. 1984, 64: 672-674.PubMed Kresch AJ, Seifer DB, Sachs LB, Barrese I: Laparoscopy in 100 women with chronic pelvic pain. Obstet Gynecol. 1984, 64: 672-674.PubMed
23.
go back to reference Sutton C, MacDonald R: Laser laparoscopic adhesiolysis. J Gynecol Surg. 1990, 6: 155-159. 10.1089/gyn.1990.6.155.CrossRefPubMed Sutton C, MacDonald R: Laser laparoscopic adhesiolysis. J Gynecol Surg. 1990, 6: 155-159. 10.1089/gyn.1990.6.155.CrossRefPubMed
24.
go back to reference Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, McGuire A, Lower AM, Hawthorn RJ, O’Brien F, Buchan S, Crowe AM: Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet. 1999, 353: 1476-1480. 10.1016/S0140-6736(98)09337-4.CrossRefPubMed Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, McGuire A, Lower AM, Hawthorn RJ, O’Brien F, Buchan S, Crowe AM: Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet. 1999, 353: 1476-1480. 10.1016/S0140-6736(98)09337-4.CrossRefPubMed
25.
go back to reference Diamond MP, Wexner SD, DiZerega GS: Adhesion prevention and reduction: current status and future recommendations of a multinationalinter-disciplinary consensus conference. Surg Innov. 2012, 17: 183-188.CrossRef Diamond MP, Wexner SD, DiZerega GS: Adhesion prevention and reduction: current status and future recommendations of a multinationalinter-disciplinary consensus conference. Surg Innov. 2012, 17: 183-188.CrossRef
26.
go back to reference McEntee G, Pender D, Mulvin D, McCullough M, Naeeder S, Farah S, Badurdeen MS, Ferraro V, Cham C, Gillham N: Current spectrum of intestinal obstruction. Br J Surg. 1987, 74: 976-980. 10.1002/bjs.1800741105.CrossRefPubMed McEntee G, Pender D, Mulvin D, McCullough M, Naeeder S, Farah S, Badurdeen MS, Ferraro V, Cham C, Gillham N: Current spectrum of intestinal obstruction. Br J Surg. 1987, 74: 976-980. 10.1002/bjs.1800741105.CrossRefPubMed
27.
go back to reference Prushik SG, Stucchi AF, Matteotti R, Aarons CB, Reed KL, Gower AC, Becker JM: Open adhesiolysis is more effective in reducing adhesion reformation than laparoscopic adhesiolysis in an experimental model. Br J Surg. 2010, 97: 420-427. 10.1002/bjs.6899.CrossRefPubMed Prushik SG, Stucchi AF, Matteotti R, Aarons CB, Reed KL, Gower AC, Becker JM: Open adhesiolysis is more effective in reducing adhesion reformation than laparoscopic adhesiolysis in an experimental model. Br J Surg. 2010, 97: 420-427. 10.1002/bjs.6899.CrossRefPubMed
28.
go back to reference Catena F, Di Saverio S, Kelly MD, Biffl WL, Ansaloni L, Mandalà V: Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2010 evidence-based guidelines of the world society of emergency surgery. World J Emerg Surg. 2011, 6: 5-10.1186/1749-7922-6-5. 21PubMedCentralCrossRefPubMed Catena F, Di Saverio S, Kelly MD, Biffl WL, Ansaloni L, Mandalà V: Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2010 evidence-based guidelines of the world society of emergency surgery. World J Emerg Surg. 2011, 6: 5-10.1186/1749-7922-6-5. 21PubMedCentralCrossRefPubMed
29.
go back to reference Ray NF, Larsen JW, Stillman RJ, Jacobs RJ: Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988. Surg Gynecol Obstet. 1993, 176: 271-276.PubMed Ray NF, Larsen JW, Stillman RJ, Jacobs RJ: Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988. Surg Gynecol Obstet. 1993, 176: 271-276.PubMed
30.
go back to reference Ray NF, Denton WG, Thamer M, Henderson SC, Perry S: Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg. 1998, 186: 1-9. 10.1016/S1072-7515(97)00127-0.CrossRefPubMed Ray NF, Denton WG, Thamer M, Henderson SC, Perry S: Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg. 1998, 186: 1-9. 10.1016/S1072-7515(97)00127-0.CrossRefPubMed
31.
32.
go back to reference Ellis H, Crowe A: Medico-legal consequences of post-operative intra-abdominal adhesions. Int J Surg. 2009, 7: 187-191. 10.1016/j.ijsu.2009.04.004.CrossRefPubMed Ellis H, Crowe A: Medico-legal consequences of post-operative intra-abdominal adhesions. Int J Surg. 2009, 7: 187-191. 10.1016/j.ijsu.2009.04.004.CrossRefPubMed
33.
go back to reference Wiseman DM, Trout JR, Diamond MP: The rates of adhesion adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery. Fertil Steril. 1998, 70: 702-711. 10.1016/S0015-0282(98)00270-2.CrossRefPubMed Wiseman DM, Trout JR, Diamond MP: The rates of adhesion adhesion development and the effects of crystalloid solutions on adhesion development in pelvic surgery. Fertil Steril. 1998, 70: 702-711. 10.1016/S0015-0282(98)00270-2.CrossRefPubMed
34.
go back to reference Holmdahl L, Eriksson E, Eriksson BI, Risberg B: Depression of peritoneal fibrinolysis during operation is a local response to trauma. Surgery. 1998, 123: 539-544. 10.1067/msy.1998.86984.CrossRefPubMed Holmdahl L, Eriksson E, Eriksson BI, Risberg B: Depression of peritoneal fibrinolysis during operation is a local response to trauma. Surgery. 1998, 123: 539-544. 10.1067/msy.1998.86984.CrossRefPubMed
35.
go back to reference Ivarsson ML, Bergström M, Eriksson E, Risberg B, Holmdahl L: Tissue markers as predictors of postoperative adhesions. Br J Surg. 1998, 85: 1549-1554. 10.1046/j.1365-2168.1998.00859.x.CrossRefPubMed Ivarsson ML, Bergström M, Eriksson E, Risberg B, Holmdahl L: Tissue markers as predictors of postoperative adhesions. Br J Surg. 1998, 85: 1549-1554. 10.1046/j.1365-2168.1998.00859.x.CrossRefPubMed
36.
go back to reference Holmdahl L, Kotseos K, Bergström M, Falk P, Ivarsson ML, Chegini N: Overproduction of transforming growth factorbeta1 (TGF-beta1) is associated with adhesion formation and peritoneal fibrinolytic impairment. Surgery. 2001, 129: 626-632. 10.1067/msy.2001.113039.CrossRefPubMed Holmdahl L, Kotseos K, Bergström M, Falk P, Ivarsson ML, Chegini N: Overproduction of transforming growth factorbeta1 (TGF-beta1) is associated with adhesion formation and peritoneal fibrinolytic impairment. Surgery. 2001, 129: 626-632. 10.1067/msy.2001.113039.CrossRefPubMed
37.
go back to reference Chegini N, Kotseos K, Zhao Y, Bennett B, McLean FW, Diamond MP, Holmdahl L, Burns J: Differential expression of TGF-beta1 and TGF-beta3 in serosal tissues of human intraperitoneal organs and peritoneal adhesions. Hum Reprod. 2001, 16: 1291-1300. 10.1093/humrep/16.6.1291.CrossRefPubMed Chegini N, Kotseos K, Zhao Y, Bennett B, McLean FW, Diamond MP, Holmdahl L, Burns J: Differential expression of TGF-beta1 and TGF-beta3 in serosal tissues of human intraperitoneal organs and peritoneal adhesions. Hum Reprod. 2001, 16: 1291-1300. 10.1093/humrep/16.6.1291.CrossRefPubMed
38.
go back to reference Cheong YC, Shelton JB, Laird SM, Li TC, Ledger WL, Cooke ID: Peritoneal fluid concentrations of matrix metalloproteinase- 9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions. Fertil Steril. 2003, 79: 1168-1175. 10.1016/S0015-0282(03)00079-7.CrossRefPubMed Cheong YC, Shelton JB, Laird SM, Li TC, Ledger WL, Cooke ID: Peritoneal fluid concentrations of matrix metalloproteinase- 9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions. Fertil Steril. 2003, 79: 1168-1175. 10.1016/S0015-0282(03)00079-7.CrossRefPubMed
39.
go back to reference Molinas CR, Campo R, Elkelani OA, Binda MM, Carmeliet P, Koninckx PR: Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril. 2003, 80 (Suppl 2): 795-802.CrossRefPubMed Molinas CR, Campo R, Elkelani OA, Binda MM, Carmeliet P, Koninckx PR: Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril. 2003, 80 (Suppl 2): 795-802.CrossRefPubMed
40.
go back to reference Segura T, Schmokel H, Hubbell JA: RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. J Surg Res. 2007, 141: 162-170. 10.1016/j.jss.2006.07.045.CrossRefPubMed Segura T, Schmokel H, Hubbell JA: RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. J Surg Res. 2007, 141: 162-170. 10.1016/j.jss.2006.07.045.CrossRefPubMed
41.
go back to reference Cahill RA, Wang JH, Soohkai S, Redmond HP: Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery. 2006, 140: 108-112. 10.1016/j.surg.2006.01.020.CrossRefPubMed Cahill RA, Wang JH, Soohkai S, Redmond HP: Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery. 2006, 140: 108-112. 10.1016/j.surg.2006.01.020.CrossRefPubMed
42.
go back to reference Avsar FM, Sahin M, Aksoy F, Avsar AF, Akoz M, Hengirmen S, Bilici S: Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. Am J Surg. 2001, 181 (6): 512-515. 10.1016/S0002-9610(01)00617-1.CrossRefPubMed Avsar FM, Sahin M, Aksoy F, Avsar AF, Akoz M, Hengirmen S, Bilici S: Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. Am J Surg. 2001, 181 (6): 512-515. 10.1016/S0002-9610(01)00617-1.CrossRefPubMed
43.
go back to reference Sahin M, Cakir M, Avsar FM, Tekin A, Kucukkartallar T, Akoz M: The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions). Inflammation. 2007, 30 (6): 244-249. 10.1007/s10753-007-9043-1.CrossRefPubMed Sahin M, Cakir M, Avsar FM, Tekin A, Kucukkartallar T, Akoz M: The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions). Inflammation. 2007, 30 (6): 244-249. 10.1007/s10753-007-9043-1.CrossRefPubMed
44.
go back to reference Muzii L, Marana R, Brunetti L, Margutti F, Vacca M, Mancuso S: Postoperative adhesion prevention with low-dose aspirin: effect through the selective inhibition of thromboxane production. Hum Reprod. 1998, 13 (6): 1486-1489. 10.1093/humrep/13.6.1486.CrossRefPubMed Muzii L, Marana R, Brunetti L, Margutti F, Vacca M, Mancuso S: Postoperative adhesion prevention with low-dose aspirin: effect through the selective inhibition of thromboxane production. Hum Reprod. 1998, 13 (6): 1486-1489. 10.1093/humrep/13.6.1486.CrossRefPubMed
45.
go back to reference Oh SH, Kim JK, Song KS, Noh SM, Ghil SH, Yuk SH, Lee JH: Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol–gel transition behavior. J Biomed Mater Res A. 2005, 72 (3): 306-316.CrossRefPubMed Oh SH, Kim JK, Song KS, Noh SM, Ghil SH, Yuk SH, Lee JH: Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol–gel transition behavior. J Biomed Mater Res A. 2005, 72 (3): 306-316.CrossRefPubMed
46.
go back to reference Rodgers KE, Johns DB, Girgis W, diZerega GS: Prevention of adhesion formation with intraperitoneal administration of tolmetin and hyaluronic acid. J Invest Surg. 1997, 10 (6): 367-373. 10.3109/08941939709099600.CrossRefPubMed Rodgers KE, Johns DB, Girgis W, diZerega GS: Prevention of adhesion formation with intraperitoneal administration of tolmetin and hyaluronic acid. J Invest Surg. 1997, 10 (6): 367-373. 10.3109/08941939709099600.CrossRefPubMed
47.
go back to reference Aldemir M, Ozturk H, Erten C, Buyukbayram H: The preventive effect of rofecoxib in postoperative Intraperitoneal adhesions. Acta Chir Belg. 2004, 104 (1): 97-100.PubMed Aldemir M, Ozturk H, Erten C, Buyukbayram H: The preventive effect of rofecoxib in postoperative Intraperitoneal adhesions. Acta Chir Belg. 2004, 104 (1): 97-100.PubMed
48.
go back to reference Fukasawa M, Girgis W, diZerega GS: Inhibition of postsurgical adhesions in a standardized rabbit model: II. Intraperitoneal treatment with heparin. Int J Fertil. 1991, 36 (5): 296-301.PubMed Fukasawa M, Girgis W, diZerega GS: Inhibition of postsurgical adhesions in a standardized rabbit model: II. Intraperitoneal treatment with heparin. Int J Fertil. 1991, 36 (5): 296-301.PubMed
49.
go back to reference Kutlay J, Ozer Y, Isik B, Kargici H: Comparative effectiveness of several agents for preventing postoperative adhesions. World J Surg. 2004, 28 (7): 662-665. 10.1007/s00268-004-6825-6.CrossRefPubMed Kutlay J, Ozer Y, Isik B, Kargici H: Comparative effectiveness of several agents for preventing postoperative adhesions. World J Surg. 2004, 28 (7): 662-665. 10.1007/s00268-004-6825-6.CrossRefPubMed
50.
go back to reference Parsak CK, Satar S, Akcam T, Satar D, Sungur I: Effectiveness of treatment to prevent adhesions after abdominal surgery: an experimental evaluation in rats. Adv Ther. 2007, 24 (4): 796-802. 10.1007/BF02849972.CrossRefPubMed Parsak CK, Satar S, Akcam T, Satar D, Sungur I: Effectiveness of treatment to prevent adhesions after abdominal surgery: an experimental evaluation in rats. Adv Ther. 2007, 24 (4): 796-802. 10.1007/BF02849972.CrossRefPubMed
51.
go back to reference Aarons CB, Cohen PA, Gower A, Reed KL, Leeman SE, Stucchi AF: Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg. 2007, 245: 176-184. 10.1097/01.sla.0000236627.07927.7c.PubMedCentralCrossRefPubMed Aarons CB, Cohen PA, Gower A, Reed KL, Leeman SE, Stucchi AF: Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg. 2007, 245: 176-184. 10.1097/01.sla.0000236627.07927.7c.PubMedCentralCrossRefPubMed
52.
go back to reference Dorr PJ, Vemer HM, Brommer EJ, Willemsen WN, Veldhuizen RW, Rolland R: Prevention of postoperative adhesions by tissuetype plasminogen activator (t-PA) in the rabbit. Eur J Obstet Gynecol Reprod Biol. 1990, 37 (3): 287-291. 10.1016/0028-2243(90)90037-2.CrossRefPubMed Dorr PJ, Vemer HM, Brommer EJ, Willemsen WN, Veldhuizen RW, Rolland R: Prevention of postoperative adhesions by tissuetype plasminogen activator (t-PA) in the rabbit. Eur J Obstet Gynecol Reprod Biol. 1990, 37 (3): 287-291. 10.1016/0028-2243(90)90037-2.CrossRefPubMed
53.
go back to reference Celeplı S, Kismet K, Kaptanoğlu B, Erel S, Ozer S, Celeplı P: The effect of oral honey and pollen on postoperative intraabdominal adhesions. Turk J Gastroenterol. 2011, 22: 65-72.PubMed Celeplı S, Kismet K, Kaptanoğlu B, Erel S, Ozer S, Celeplı P: The effect of oral honey and pollen on postoperative intraabdominal adhesions. Turk J Gastroenterol. 2011, 22: 65-72.PubMed
54.
go back to reference Fang CC, Chou TH, Lin GS, Yen ZS, Lee CC, Chen SC: Peritoneal infusion with cold saline decreased postoperative intra-abdominal adhesion formation. World J Surg. 2010, 34: 721-727. 10.1007/s00268-009-0378-7.CrossRefPubMed Fang CC, Chou TH, Lin GS, Yen ZS, Lee CC, Chen SC: Peritoneal infusion with cold saline decreased postoperative intra-abdominal adhesion formation. World J Surg. 2010, 34: 721-727. 10.1007/s00268-009-0378-7.CrossRefPubMed
55.
go back to reference Atta HM, Al-Hendy A, El-Rehany MA, Dewerchin M, Abdel Raheim SR, Abdel Ghany H, Fouad R: Adenovirusmediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats. Surgery. 2009, 146: 12-17. 10.1016/j.surg.2009.02.018.CrossRefPubMed Atta HM, Al-Hendy A, El-Rehany MA, Dewerchin M, Abdel Raheim SR, Abdel Ghany H, Fouad R: Adenovirusmediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats. Surgery. 2009, 146: 12-17. 10.1016/j.surg.2009.02.018.CrossRefPubMed
56.
go back to reference Guo H, Leung JC, Cheung JS, Chan LY, Wu EX, Lai KN: Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model. Br J Surg. 2009, 96: 1323-1335. 10.1002/bjs.6722.CrossRefPubMed Guo H, Leung JC, Cheung JS, Chan LY, Wu EX, Lai KN: Non-viral Smad7 gene delivery and attenuation of postoperative peritoneal adhesion in an experimental model. Br J Surg. 2009, 96: 1323-1335. 10.1002/bjs.6722.CrossRefPubMed
57.
go back to reference Guo Q, Li QF, Liu HJ, Li R, Wu CT, Wang LS: Sphingosine kinase 1 gene transfer reduces postoperative peritoneal adhesion in an experimental model. Br J Surg. 2008, 95: 252-258.CrossRefPubMed Guo Q, Li QF, Liu HJ, Li R, Wu CT, Wang LS: Sphingosine kinase 1 gene transfer reduces postoperative peritoneal adhesion in an experimental model. Br J Surg. 2008, 95: 252-258.CrossRefPubMed
58.
go back to reference Liu HJ, Wu CT, Duan HF, Wu B, Lu ZZ, Wang L: Adenoviral- mediated gene expression of hepatocyte growth factor prevents postoperative peritoneal adhesion in a rat model. Surgery. 2006, 140: 441-447. 10.1016/j.surg.2005.12.014.CrossRefPubMed Liu HJ, Wu CT, Duan HF, Wu B, Lu ZZ, Wang L: Adenoviral- mediated gene expression of hepatocyte growth factor prevents postoperative peritoneal adhesion in a rat model. Surgery. 2006, 140: 441-447. 10.1016/j.surg.2005.12.014.CrossRefPubMed
59.
go back to reference Brochhausen C, Schmitt VH, Planck CN, Rajab TK, Hollemann D, Tapprich C: Current strategies and future perspectives for Intraperitoneal adhesion prevention. J Gastrointest Surg. 2012, Epub ahead of print Brochhausen C, Schmitt VH, Planck CN, Rajab TK, Hollemann D, Tapprich C: Current strategies and future perspectives for Intraperitoneal adhesion prevention. J Gastrointest Surg. 2012, Epub ahead of print
60.
go back to reference Hellebrekers BW, Kooistra T: Pathogenesis of postoperative adhesion formation. Br J Surg. 2011, 98: 1503-1516. 10.1002/bjs.7657.CrossRefPubMed Hellebrekers BW, Kooistra T: Pathogenesis of postoperative adhesion formation. Br J Surg. 2011, 98: 1503-1516. 10.1002/bjs.7657.CrossRefPubMed
Metadata
Title
Peritoneal adhesion index (PAI): proposal of a score for the “ignored iceberg” of medicine and surgery
Authors
Federico Coccolini
Luca Ansaloni
Roberto Manfredi
Luca Campanati
Elia Poiasina
Paolo Bertoli
Michela Giulii Capponi
Massimo Sartelli
Salomone Di Saverio
Michele Cucchi
Daniel Lazzareschi
Michele Pisano
Fausto Catena
Publication date
01-12-2013
Publisher
BioMed Central
Published in
World Journal of Emergency Surgery / Issue 1/2013
Electronic ISSN: 1749-7922
DOI
https://doi.org/10.1186/1749-7922-8-6

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Reviewer acknowledgement

Reviewer Acknowledgement 2012