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World Journal of Surgery

Published in:

01-04-2010

Peritoneal Infusion with Cold Saline Decreased Postoperative Intra-Abdominal Adhesion Formation

Authors: Cheng-Chung Fang, Tzung-Hsin Chou, Geng-Shiau Lin, Zui-Shen Yen, Chien-Chang Lee, Shyr-Chyr Chen

Published in: World Journal of Surgery | Issue 4/2010

Abstract

Background

Postoperative intra-abdominal adhesion is a common morbidity after laparotomy. We try to determine whether peritoneal infusion with cold saline may decrease postoperative intra-abdominal adhesion formation.

Methods

Ninety-six male BALB/c mice weighing 25-30 g were randomized into four groups: (I) adhesion model with infusion of 4°C cold saline, (II) adhesion model with infusion of room temperature saline, (III) adhesion model without infusion of saline, and (IV) sham operation without infusion of saline. Adhesion scores, incidence of adhesion, and serum cytokines were measured at postoperative days 1, 3, 7, and 14.

Results

Group I had lower adhesion scores than groups II and III (P < 0.0001). IL-6, IL-10, and TNF-α were significantly increased in the groups I, II, and III compared to group IV (P < 0.0001). IL-6 in group I was significantly decreased compared to that in group III (P < 0.0004). IL-10 in group I was significantly increased compared to that in groups II (P < 0.0001) and III (P < 0.05). TNF-α in group I was significantly decreased compared to that in groups II (P < 0.0004), and III (P < 0.05).

Conclusion

Peritoneal infusion with cold saline may decrease the degree of postoperative intra-abdominal adhesion formation.

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Title: Peritoneal Infusion with Cold Saline Decreased Postoperative Intra-Abdominal Adhesion Formation
Authors: Cheng-Chung Fang
Tzung-Hsin Chou
Geng-Shiau Lin
Zui-Shen Yen
Chien-Chang Lee
Shyr-Chyr Chen
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: World Journal of Surgery / Issue 4/2010
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-009-0378-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Peritoneal Infusion with Cold Saline Decreased Postoperative Intra-Abdominal Adhesion Formation

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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