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Radiation Oncology
Published in: Radiation Oncology 1/2014

Open Access 01-12-2014 | Research

Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients

Authors: Hideomi Yamashita, Hiroshi Onishi, Yasuo Matsumoto, Naoya Murakami, Yukinori Matsuo, Takuma Nomiya, Keiichi Nakagawa, Japanese Radiological Society multi-institutional SBRT study group (JRS-SBRTSG)

Published in: Radiation Oncology | Issue 1/2014

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Abstract

Background and aims

Stereotactic body radiotherapy (SBRT) is a relatively new treatment for liver tumor. The outcomes of SBRT for liver tumor unfit for ablation and surgical resection were evaluated.

Methods

Liver tumor patients treated with SBRT in seven Japanese institutions were studied retrospectively. Patients given SBRT for liver tumor between 2004 and 2012 were collected. Patients treated with SBRT preceded by trans-arterial chemoembolization (TACE) were eligible. Seventy-nine patients with hepatocellular carcinoma (HCC) and 51 patients with metastatic liver tumor were collected. The median biologically effective dose (BED) (α/β = 10 Gy) was 96.3 Gy for patients with HCC and 105.6 Gy with metastatic liver tumor.

Results

The median follow-up time was 475.5 days in patients with HCC and 212.5 days with metastatic liver tumor. The 2-year local control rate (LCR) for HCC and metastatic liver tumor was 74.8% ± 6.3% and 64.2 ± 9.5% (p = 0.44). The LCR was not different between BED10 ≥ 100 Gy and < 100 Gy (p = 0.61). The LCR was significantly different between maximum tumor diameter > 30 mm vs. ≤ 30 mm (64% vs. 85%, p = 0.040) in all 130 patients. No grade 3 laboratory toxicities in the acute, sub-acute and chronic phases were observed.

Conclusions

There was no difference in local control after SBRT in the range of median BED10 around 100 Gy for between HCC and metastatic liver tumor. SBRT is safe and might be an alternative method to resection and ablation.

Summary

There was no difference in local control after SBRT in the range of median BED10 around 100 Gy for between HCC and metastatic liver tumor and SBRT is safe and might be an alternative method to resection and ablation.
Appendix
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Metadata
Title
Local effect of stereotactic body radiotherapy for primary and metastatic liver tumors in 130 Japanese patients
Authors
Hideomi Yamashita
Hiroshi Onishi
Yasuo Matsumoto
Naoya Murakami
Yukinori Matsuo
Takuma Nomiya
Keiichi Nakagawa
Japanese Radiological Society multi-institutional SBRT study group (JRS-SBRTSG)
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2014
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-9-112

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