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Open Access 01-12-2010 | Research

Dosimetric comparison using different multileaf collimeters in intensity-modulated radiotherapy for upper thoracic esophageal cancer

Authors: Youling Gong, Shichao Wang, Lin Zhou, Yongmei Liu, Yong Xu, You Lu, Sen Bai, Yuchuan Fu, Qingfeng Xu, Qingfeng Jiang

Published in: Radiation Oncology | Issue 1/2010

Abstract

Purpose

To study the impacts of multileaf collimators (MLC) width [standard MLC width of 10 mm (sMLC) and micro-MLC width of 4 mm (mMLC)] in the intensity-modulated radiotherapy (IMRT) planning for the upper thoracic esophageal cancer (UTEC).

Methods and materials

10 patients with UTEC were retrospectively planned with the sMLC and the mMLC. The monitor unites (MUs) and dose volume histogram-based parameters [conformity index (CI) and homogeneous index (HI)] were compared between the IMRT plans with sMLC and with mMLC.

Results

The IMRT plans with the mMLC were more efficient (average MUs: 703.1 ± 68.3) than plans with the sMLC (average MUs: 833.4 ± 73.8) (p < 0.05). Also, compared to plans with the sMLC, the plans with the mMLC showed advantages in dose coverage of the planning gross tumor volume (Pgtv) (CI 0.706 ± 0.056/HI 1.093 ± 0.021) and the planning target volume (PTV) (CI 0.707 ± 0.029/HI 1.315 ± 0.013) (p < 0.05). In addition, the significant dose sparing in the D₅ (3260.3 ± 374.0 vs 3404.5 ± 374.4)/gEUD (1815.1 ± 281.7 vs 1849.2 ± 297.6) of the spinal cord, the V₁₀ (33.2 ± 6.5 vs 34.0 ± 6.7), V₂₀ (16.0 ± 4.6 vs 16.6 ± 4.7), MLD (866.2 ± 174.1 vs 887.9 ± 172.1) and gEUD (938.6 ± 175.2 vs 956.8 ± 171.0) of the lungs were observed in the plans with the mMLC, respectively (p < 0.05).

Conclusions

Comparing to the sMLC, the mMLC not only demonstrated higher efficiencies and more optimal target coverage, but also considerably improved the dose sparing of OARs in the IMRT planning for UTEC.

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Title: Dosimetric comparison using different multileaf collimeters in intensity-modulated radiotherapy for upper thoracic esophageal cancer
Authors: Youling Gong
Shichao Wang
Lin Zhou
Yongmei Liu
Yong Xu
You Lu
Sen Bai
Yuchuan Fu
Qingfeng Xu
Qingfeng Jiang
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-65

At a glance: The STEP trials

Springer Medicine

Dosimetric comparison using different multileaf collimeters in intensity-modulated radiotherapy for upper thoracic esophageal cancer

Abstract

Purpose

Methods and materials

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods and materials

Results

Conclusions

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