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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Research

The expression and clinical significance of miR-132 in gastric cancer patients

Authors: Xiaowen Liu, Hongmei Yu, Hong Cai, Yanong Wang

Published in: Diagnostic Pathology | Issue 1/2014

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Abstract

Background and objective

miR-132 plays a role in regulating neuronal morphology and cellular excitability. Little is known about the effects of miR-132 in cancer. The aim of this study is to evaluate the expression of miR-132 and its clinical significance in gastric cancer.

Methods

Cancerous tissues and corresponding normal tissues from 79 patients with gastric cancer were examined for the expression of miR-132 using quantitative PCR and the association between miR-132 expression levels and clinicopathological factors and prognosis was analyzed.

Results

In 79 clinical samples of gastric cancer patients, miR-132 expression levels in cancer tissues were significantly higher than those in the corresponding normal tissues (P = 0.001). Higher expression levels of miR-132 were associated with more frequent lymph node metastasis (P = 0.033), more lymphatic tumor emboli (P = 0.007), and more advanced stage (P = 0.016). Additionally, expression of miR-132 was an independent prognostic factor for overall survival (P = 0.020).

Conclusion

miR-132 could serve as an efficient prognostic factor for gastric cancer patients.

Virtual slides

The virtual slide(s) for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​8168577241196050​
Appendix
Available only for authorised users
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Metadata
Title
The expression and clinical significance of miR-132 in gastric cancer patients
Authors
Xiaowen Liu
Hongmei Yu
Hong Cai
Yanong Wang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-9-57

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