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Diagnostic Pathology

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Open Access 01-12-2012 | Research

Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma

Authors: Jingchun Jin, Tiefeng Jin, Meiling Quan, Yingshi Piao, Zhenhua Lin

Published in: Diagnostic Pathology | Issue 1/2012

Abstract

Background

Ezrin is a cytoskeletal protein that is involved in tumor growth and invasion. It has been suggested that Ezrin expression plays an important role in tumor metastasis. This study is aimed to investigate the clinicopathological significance of Ezrin overexpression in gastric adenocarcinomas.

Methods

Ezrin protein expression was examined by immunohistochemistry in 26 normal gastric mucosa, 32 dysplasia, and 277 gastric adenocarcinomas. The relationship between Ezrin expression and the clinicopathological features of gastric cancers was analyzed. In addition, a gastric cancer cell line, MKN-1, was also used for immunofluorescence staining to evaluate the distribution of Ezrin protein.

Results

Ezrin protein located in the cytoplasm and/or membrane in the migrating gastric cancer cells, and it mainly concentrated at the protrusion site; however, only cytoplasmic distribution was observed in the non-migrating cancer cells by immunofluorescence staining. The positive rate of Ezrin protein expression was significantly higher in gastric adenocarcinoma and dysplasia compared with that in the normal gastric mucosa. Moreover, expression frequency of Ezrin protein increased significantly in lymph node metastasis and late clinical stages. Consistently, strong expression of Ezrin was significantly correlated with poor prognosis of gastric cancer.

Conclusion

The detection of Ezrin expression can be used as the marker for early diagnosis and prognosis of gastric adenocarcinoma.

Virtual Slides

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Title: Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma
Authors: Jingchun Jin
Tiefeng Jin
Meiling Quan
Yingshi Piao
Zhenhua Lin
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2012
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-7-135

At a glance: The STEP trials

Springer Medicine

Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma

Abstract

Background

Methods

Results

Conclusion

Virtual Slides

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Virtual Slides

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