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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2013

Open Access 01-12-2013 | Research

CD44/CD24 immunophenotypes on clinicopathologic features of salivary glands malignant neoplasms

Authors: Danilo Figueiredo Soave, João Paulo Oliveira da Costa, Giorgia Gobbi da Silveira, Renata Carolina Fraga Ianez, Lucinei Roberto de Oliveira, Silvia Vanessa Lourenço, Alfredo Ribeiro-Silva

Published in: Diagnostic Pathology | Issue 1/2013

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Abstract

Background

Salivary Glands Malignant Neoplasms (SGMNs) account for 3-6% of head and neck cancers and 0.3% of all cancers. Tumor cells that express CD44 and CD24 exhibit a stem-cell-like behavior. CD44 is the binding site for hyaluronic acid, and CD24 is a receptor that interacts with P-selectin to induce metastasis and tumor progression. The present study aims to evaluate the expression of CD44 and CD24 on SGMNs and correlated these data with several clinicopathologic features.

Methods

Immunohistochemical stains for CD44 and CD24 were performed on tissue microarrays containing SGMN samples from 69 patients. The CD44, CD24 and CD44/CD24 expression phenotypes were correlated to patient clinicopathologic features and outcome.

Results

CD44 expression was associated with the primary site of neoplasm (p = 0.046). CD24 was associated with clinical stage III/IV (p = 0.008), T stage (p = 0,27) and lymph node (p = 0,001). The CD44/CD24 profiles were associated with the primary site of injury (p = 0.005), lymph node (p = 0.011) and T stage (p = 0.023). Univariate analysis showed a significant relationship between clinical staging and disease- free survival (p = 0.009), and the overall survival presents relation with male gender (p = 0.011) and metastasis (p = 0.027).

Conclusion

In summary, our investigation confirms that the clinical stage, in accordance with the literature, is the main prognostic factor for SGMN. Additionally, we have presented some evidence that the analysis of isolated CD44 and CD24 immunoexpression or the two combined markers could give prognostic information associated to clinicopathologic features in SGMN.

Virtual Slides

The virtual slide(s) for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​1284611098470676​.
Appendix
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Metadata
Title
CD44/CD24 immunophenotypes on clinicopathologic features of salivary glands malignant neoplasms
Authors
Danilo Figueiredo Soave
João Paulo Oliveira da Costa
Giorgia Gobbi da Silveira
Renata Carolina Fraga Ianez
Lucinei Roberto de Oliveira
Silvia Vanessa Lourenço
Alfredo Ribeiro-Silva
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2013
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-8-29

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